Biomedical subjects
Publications and source records attributed to S P Lisser.
The diagnosis and treatment of common hand infections are reviewed. A practical approach to the treatment of these conditions is detailed. This approach emphasizes the anatomic compartments of the hand, the microbiology of infecting organisms, and the patient conditions which modify treatment. Prompt and accurate diagnosis, treatment, and rehabilitation are key for optimal outcome.
This study evaluates the reversibility of the effects of gossypol on testicular ultrastructure and the motility of epididymal spermatozoa. Adult male rats were treated 6 days weekly with the vehicle alone (Group A), or with 10 (Group B) or 20 (Group C) mg/kg of gossypol for 12 weeks, and then sacrificed six or 12 weeks after cessation of treatment. Although epididymal spermatozoa in Groups B and C were 100% immotile after gossypol treatment, little evidence of abnormality could be detected with the light microscope in the seminiferous tubules or interstitium. By contrast, at the ultrastructural level, there were demonstrable pathognomonic defects in the mitochondrial sheath and axonemes of step 18 and 19 spermatids which were identical to those reported earlier (Hoffer, 1983). In addition, an ultrastructural defect in the flagella of late testicular spermatozoa is described for the first time. This defect consists of an indentation, or constriction, of the mitochondrial sheath at outer dense fibers (ODFs) 1, 2, and 9, resulting in a separation of these 3 ODFs from the other fibers. This defect, though visible in an earlier ultrastructural study (Hoffer, 1983), was not described. In Group B rats allowed to recover from gossypol treatment, ultrastructural defects in step 18 and 19 spermatids could not be detected at six or at 12 weeks after cessation of treatment, and sperm motility also did not differ significantly from controls by the end of either recovery period. In Group C rats, sperm motility returned to the normal range within six weeks after treatment ended, but a few morphological defects in the midpiece and axoneme of late spermatids could still be detected with the electron microscope.(ABSTRACT TRUNCATED AT 250 WORDS)
The resistance to torsional load was measured in a human cadaver model of a surgical neck fracture. Ten fresh-frozen human cadaver shoulders were thawed, dissected free of soft tissue attachments, and analyzed with dual energy x-ray absorptiometry to establish bone mineral density. Osteotomies were fixed with figure-of-eight wire alone and figure-of-eight wire supplemented with intramedullary Enders rods. Intramedullary Enders rods improved the mean maximum load by 1.5 times (p < 0.05). No statistically significant correlation was found between mean maximum load and bone mineral density.