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Biomedical subjects

S P Grigor'eva

Publications and source records attributed to S P Grigor'eva.

At least 19 recordsLinked to original sources
PubMed2006

[Long-term results of bronchial resection and plastic repair in patients with lung cancer].

Thoracic units perform plastic operations on the bronchi in 5-10% of all radical interventions for lung cancer. This figure was 7.5% at our unit. A total of 184 patients were operated on, with a mortality rate of 9.7% (18 patients died). Lobectomy with circulatory resection of the main bronchus is the optimal plastic operation on the bronchi in lung cancer. Long-term results following bronchial resection and plastic repair suggest the oncological rationale for these operations. These operations make it possible to preserve functionally significant lung tissue, thus assuring the high quality of life in the patient.

Adult↗
PubMed1992

[Combined resections in the surgery of lung cancer].

Operations were performed on 3,313 patients for lung carcinoma in the Department of Surgery of the Lungs and Mediastinum of the National Research Center of Surgery, AMS USSR, from 1963 till 1.01.90. Among these patients 263 (7.9%) were treated by combined operations (resection of the lung together with part of the chest wall, trachea and its bifurcation, pericardium, diaphragm, superior vena cava, pulmonary artery, aorta, and atrium, and also with removal of metastatic lymph nodes of the contralateral lung). Three types of combined resections were carried out--vasculo-atrial, tracheo-bronchial, and parieto-diaphragmatic. Postoperative complications developed in 38.6% of patients. Intraoperative mortality was 1.5%, 13.9% of patients died after the operation. More than 5 years survived 21.8% of patients who underwent operation, more than 10 years 10.2%, and more than 15 years 5.6% of patients.

Age Factors↗
PubMed1992

[Repeat uni- and bilateral operations in surgery for multiple primary cancer of the lungs and intrathoracic metastases].

Repeated uni- and bilateral resections of the lungs conducted from 1963 to 01.01.91 at the Department of Surgery of the Lungs and Mediastinum of the National Research Center of Surgery, USSR AMS for primary multiple carcinoma (13 patients) and metastatic lesions (32 patients) accounted for 1.3% of all operations in lung carcinoma. Such interventions are more justified in differentiated forms of primary multiple carcinoma and in solitary and occasional metastases of malignant tumors of various localization to the lungs. Morphological signs are the main differential diagnostic criteria of primary multiple carcinoma and intrapulmonary metastases. The main principle of surgical treatment of patients with primary multiple carcinoma and metastatic involvement of the lungs is an economical character of the operation with maximally admissible, from the oncological standpoint, preservation of functionally valuable pulmonary tissue. The combined method of treatment (operation + drug antineoplastic therapy) should take the leading place in the management of patients with intrapulmonary metastases of malignant tumors.

Adult↗
PubMed1992

[Surgical treatment of lung cancer extending into the thoracic wall].

In the Department of Surgery of Lungs and Mediastinum, National Research Centre of Surgery, USSR AMS, 88 patients underwent operation for lung carcinoma extending into the thoracic wall (which accounted for 2.6% of all patients who were operated on for carcinoma of the lungs) from 1963 to December 1990. Surgical treatment of such patients is the method of choice. The performance of both radical and palliative operations is expedient. The survival of patients after operation is determined by the depth of invasion of the thoracic wall by lung carcinoma and the condition of intrathoracic lymph nodes.

Adult↗
PubMed1992

[Reoperation in primary malignant tumors of the lung operated earlier].

Retrospective analysis of 3,441 operations carried out in the Department of Pulmonary and Mediastinal Surgery, National Research Centre of Surgery, USSR Academy of Medical Sciences, from 1963 to 1990 for carcinoma and other malignant tumors of the lung showed that in 19 (0.6%) patients surgical interventions had been conducted on the same lung. Nonspecific pulmonary diseases, tuberculosis, and localized pneumosclerosis proved to be the most common diseases for which the first thoracotomy was performed. The number of such patients is continuously growing, in view of which the authors set them apart into an independent group of patients subjected to repeated operations in lung carcinoma. Approximately in half of these patients (47.4%) the malignant tumor occurred in the lung 8 years and more after the operation carried out for a benign disease; in the others (52.6%) the tumor existed in the lung at the first operation but was not removed due to diagnostic and tactical errors or was a latent carcinoma. It is concluded that timely and proper use of diagnostic methods and a high oncological alertness even during an operation for a benign disease may facilitate improvement of the results of surgical treatment of this category of patients with lung carcinoma.

Aged↗
PubMed1991

[Economic operations in the surgical treatment of cancer of the lung].

Retrospective analysis of case records of 75 patients who were subjected to resection of a lung in a volume less than lobectomy showed that 2 types of economical operations are carried out today on patients with lung carcinoma: atypical resection and segmentectomy. According to the authors, such operations accounted for 2.4% of all lung resections for this disease. The main indication for radical resection of the lung in a volume less than lobectomy is stage I peripheral non-small-cell carcinoma (T1N0M0) in patients with serious concomitant diseases. Economical resection of the lung may be carried out in occasional cases with stage II of the disease (T2N0M0) and as a palliative measure. The late-term results provide evidence of the oncological expediency of economical operations in stage I peripheral carcinoma: for instance, 5- and 10-year survival of patients in such cases is 68.4 and 38.4%, respectively.

Adult↗
PubMed1991

[Surgical treatment of stage I lung cancer].

From analysis of the results of operative treatment of 177 patients with Stage I lung carcinoma (T1N0M0) the authors came to the conclusion that among all the existing methods of antineoplastic treatment surgery is the most effective one in differentiated tumours. Lobectomy is the operation of choice in patients with Stage I lung carcinoma. Economic resection of the lung is expedient and justified in elderly patients with Stage I peripheral carcinoma and concomitant diseases. The late-term results are evidence that surgical treatment of stage I (T1N0M0) lung carcinoma is oncologically justified: 5-year survival of patients was 64.6% after lobectomy and 67.5% after economic resection.

Adolescent↗
PubMed1990

[Malignant nonepithelial tumors of the lung].

The main peculiarities of the clinical course of lung sarcoma were determined from representative material of 134 patients. The main features differentiating malignant nonepithelial tumors from carcinoma of the lung are: younger age (average age 45.5 years), predominantly peripheral clinico-anatomical form (82.8%), and prevalent hematogenic metastasis. Five-year survival in the whole group of patients after surgical treatment was 54%. The size and histological form of the tumor are the main factors of prognosis. The degree of differentiation acquires prognostic significance in tumors measuring more than 3 cm in diameter.

Adult↗
PubMed1990

[Surgical treatment of metastatic tumor of the lungs].

A total of 142 operations were carried out on 126 patients, aged from 8 to 73 years, for intrapulmonary metastases of malignant tumors of various localization. Marginal or wedge resection of the lung together with the metastasis was performed in 46 cases, the metastasis was removed by means of precision techniques in 14 and by enucleation in 10 cases. Lob/bilob/ectomy was conducted in 42 and pneumonectomy in 16 patients. The operations were of an obvious palliative character only in 3 cases. Three (2.4%) patients died after the operation. Among patients who were operated on for metastatic tumors of the lungs, total 3-year survival was encountered in 49.7%, 5-year survival in 36.9%, and 10-year survival in 30.6% of cases. The most favourable results were recorded in patients with solitary metastases. Survival of patients who underwent operation for a few and, particularly, for multiple metastases was poorer.

Adolescent↗
PubMed1989

[Late results of the combined treatment of small-cell lung cancer].

The paper discusses an experience with combined treatment of 104 cases of small-cell lung cancer which included surgery. Small size of tumor matched by absence of regional and distant metastases was the major indication for surgery. All patients received chemoradiation treatment; 82 of them were followed up. Mean survival of operated patients was 35.5 months, and three-, five- and ten-year survival rates--36, 27 and 19%, respectively. Surgery appears to play a role in treatment of small-cell lung cancer, alongside with chemotherapy and radiation.

Adult↗
PubMed1986

The kanamycin resistance gene expression in Escherichia coli as affected by specific yeast sequences.

It was shown that the transcription initiation of the kanamycin resistance gene (the Km gene) from transposon Tn5 in E.coli HB101 strain can be provided by specific yeast sequences. To localize a region of the yeast DNA involved in transcription initiation, a number of hybrid plasmids containing promoterless part of the Km gene fused with DNA sequences from chromosome III of the yeast Saccharomyces cerevisiae was constructed. Comparison of nucleotide sequences lying in the LTR of the yeast transposon Tyl-17 with the consensus bacterial promoter revealed strong similarities.

Base Sequence↗
PubMed1986

Yeast centromeric plasmids as shuttle vectors between Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae.

A number of hybrid plasmids which can autonomously replicate in E. coli, B. subtilis and S. cerevisiae was constructed. Replication of these plasmids both in yeast and in B. subtilis starts on a sequences originating from Staphylococcus aureus plasmids pC194 and pE194. In yeast these hybrids are unstable like those yeast vectors which contain eukaryotic ARSs, but their stability has been increased by addition of yeast centromeric sequence. Both pC194 and pE194 DNAs contain sequences which reveal strong similarities with the yeast ARS consensus. Nevertheless the replication efficiences of these plasmids in yeast are different.

Bacillus subtilis↗
PubMed1985

Bacterial vectors which confer resistance to kanamycin.

On the base of plasmid pLD720 (a deletion derivative of the cosmid vector pHC79) a number of hybrid plasmids which confer in Escherichia coli cells the kanamycin resistance was constructed. All hybrid plasmids contain the promoterless part of kanamycin resistance gene (which codes for aminoglycoside 3'-phosphotransferase II) from transposon Tn5. The Km gene expression is driven by a promoters situated on pLD720. The hybrid plasmids pLD723, pLD724 and pLD728 contain a complete DNA sequences of plasmids pC194 or pE194 from Staphylococcus aureus that permits them to replicate into Bacillus subtilis as well. However, no expression of the Km gene in Bacillus subtilis was observed. There is a unical Bgl II site on pLD728 is front of the beginning of a Km gene structural part. This property of pLD728 may be useful when cloning in this plasmid a promoter sequences of different species.

Bacillus subtilis↗