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Biomedical subjects

S P Becker

Publications and source records attributed to S P Becker.

18 recordsLinked to original sources
PubMed1994

Applied anatomy of the paranasal sinuses with emphasis on endoscopic surgery.

Serial sections of frozen cadaver heads were obtained in the axial, coronal, and sagittal planes. These were analyzed with specific attention to the anatomy of the paranasal sinuses as it pertains to endoscopic sinus surgery. Important anatomic landmarks are pointed out. The use of these landmarks to guide the surgeon through the dissection and to avoid complications is discussed. The resolution of chronic sinusitis is often brought about by the structural changes secondary to endoscopic sinus surgery, and the reasons for this outcome are reviewed.

Cadaver↗
PubMed1989

Anatomy for endoscopic sinus surgery.

An understanding of the anatomy of the paranasal sinuses is essential for successful endoscopic sinus surgery. The anatomy of the sinuses is carefully described and illustrated.

Endoscopy↗
PubMed1986

Medical screening in the workplace: proposed principles.

Medical screening and biological monitoring are two techniques in a continuum of practices used to prevent occupational disease. Medical screening is the examination of workers for pathological conditions. Biological monitoring is the examination of the worker for the presence of an intoxicant or its metabolite. These techniques are common in industry, and are frequently components of health standards recommended by the National Institute for Occupational Safety and Health (NIOSH) to the Occupational Safety and Health Administration. However, an underlying set of principles for medical screening and biological monitoring in the workplace has not been delineated. In this paper, a modification of the principles for screening in the community is proposed that will be more appropriate to the workplace. This modified set of principles is not a statement of the policy of NIOSH on this important subject, but rather a presentation of the authors' views as a starting point for dialogue on these issues.

Humans↗
PubMed1984

Use of dextran and post-primary antibody fixation in immunoperoxidase staining of fresh frozen tissue. Detection of immunoglobulin associated with squamous carcinomas of the head and neck.

Use of unfixed fresh frozen tissue sections for immunocytochemical studies reduces the possibility of denaturation of antigenic determinants compared to formalin fixation and paraffin embedding procedures. However, tissue and cellular morphology can be extensively altered in the numerous application and washing steps with frozen tissue sections. We tested a number of buffer solutions and showed that the use of dextran-containing buffers and fixation by glutaraldehyde after primary antibody application preserves tissue morphology. The procedures described here are also applicable to ascertaining the presence of Fc receptors of leukocytes in sections of carcinoma tissues. The buffered dextran washes and post-primary antibody fixation method was used to demonstrate the presence of immunoglobulin associated with squamous carcinoma cells. The immunoglobulin was not removed by washing of tissue sections at 37 degrees C but could be removed by low or high pH buffer washes, suggesting that the immunoglobulin is bound in a specific manner.

Antibodies, Neoplasm↗
PubMed1981

Superior laryngeal nerve paralysis and benign thyroid disease.

A case of an isolated superior laryngeal nerve paralysis from a thyroid adenoma is presented. Superior laryngeal nerve paralyses should be sought, particularly in the preoperative and postoperative examination of thyroidectomy patients. Symptoms of a change in vocal strength or pitch and aspiration along with the laryngoscopic findings of a glottis posteriorly rotated toward a bowed vocal cord are diagnostic. Surgical trauma to the superior laryngeal nerve, though a risk of any thyroidectomy, usually can be avoided if one knows its possible anatomic variations and meticulously dissects the superior thyroid pole and its vessels.

Adenoma↗
PubMed1980

Thyroid carcinoma.

Differentiated thyroid carcinoma was studied with regard to mode of presentation, initial findings, treatment and survival. The classic signs, symptoms, physical and scan findings were found to be present in approximately 70% of the patients. Thirty percent of the patients had either unusual presentations or findings. Prognosis was found to be dependent on age of presentation more than any other factor. The effects of neck metastasis, extracapsular invasion and recurrent laryngeal nerve involvement on long-term survival are studied in detail. patients with prior exposure to radiation were found to have more extensive disease and require more extensive surgery but ultimately had the same prognosis for 15-year cure. Treatment for distant metastatic disease by surgery, radioactive iodine and external radiation all resulted in long-term survival in certain cases.

Adenocarcinoma↗
PubMed1978

Total laryngectomy and reconstruction of a pseudoglottis: problems and complications.

A modified procedure for the reconstruction of a pseudoglottis after total laryngectomy is examined. The history of this technique, including our experience, is reviewed with emphasis on problems and complications. Indications and justifications for surgery are discussed. Though we can only speculate on the basis of a few cases, we believe that a good voice can be obtained when a pseudoglottis is either primarily or secondarily constructed after laryngectomy. We acknowledge that perhaps the risk of liability tempers our approach and restricts our case selection which, no doubt, in part accounts for our modification of the procedure that was initially performed in Europe. We believe that continued careful application of this technique and its variations will improve the results of modern laryngeal surgery.

Glottis↗
PubMed1977

Mediastinal dissection--1976: indications and newer techniques.

Head and neck neoplasms may invade the mediastinum by direct extension or metastases to the tracheoesophageal or jugulo-subclavian lymph nodes. The clavicles and manubrium are a barrier to adequate resection in this type of disease. In 1962, the senior author reported six mediastinal dissections for stomal recurrences after laryngectomy. Later techniques for staging the removal of manubrium and clavicles and preparing the regional flaps were devised to avoid major complications arising from operating in this area which usually had prior treatment with radiation and/or surgery. Over 60 transsternal radical neck dissections have been performed in the past 20 years. We have in the past evaluated the morbidity and survivals in stomal cases and present here our revised indications and techniques.

Dissection↗
PubMedDate not supplied

Renal cell carcinoma with metastasis to the parotid gland: case reports and review of the literature.

Two cases of renal cell carcinoma metastatic to the parotid gland are presented. The parotid mass was the initial manifestation of the first patient's renal cell malignancy and the pathologic evaluation was the first clue to the diagnosis. The second case demonstrates discovery of metastasis to the parotid gland 8 years after resection of a hypernephroma. A review of the literature on this subject is presented and the pathologic characteristics as well as recommendations for diagnosis and treatment of this entity are reviewed.

Aged↗
PubMedDate not supplied

Evolution of the clinically negative neck.

A retrospective study was done of 602 patients with primary squamous cell carcinoma of the upper aerodigestive tract and a clinically negative neck (No) seen at the University of Illinois Hospital between 1960-1975. There was no uniform policy as to the treatment of No neck during this period; therefore in many of the patients, cervical lymph nodes were treated with elective neck dissection and others were followed until they became positive clinically. It was this difference which formed the basis for this study. All the patients were treated surgically; the patients were placed into two groups depending on whether they had radical neck dissection at the same time as resection of the primary. Group 1 consisted of 149 patients and had surgery for the primary only. The 253 patients of group 2 had surgery for the primary and also had a neck dissection. Both groups were analyzed for recurrences in the cervical region. In group 1, 12.9% of the patients developed either ipsilateral or contralateral metastases. Of the group 2 patients, 22% developed palpable nodal disease. The evolution of palpable nodal disease was analyzed by primary site, T-stage, and according to whether the tumor at the primary was controlled. Only 3% of the patients developed lymph nodes when the primary was controlled. The pathology reports of the neck specimens were studied to determine the relationship between a) positive node histology and b) number of nodes positive to the recurrence rate in the neck. Our results showed a 23% failure rate for the histologically positive group and a 21% failure rate for the negative group. The number of positive nodes did not seem to affect the recurrence rate.

Carcinoma, Squamous Cell↗