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Biomedical subjects

S Oyanagi

Publications and source records attributed to S Oyanagi.

58 records · Page 4Linked to original sources
PubMedDate not supplied

Ultrastructure of Alzheimer type II glia in hepatocerebral disease.

In a case of hepatocerebral disease of Inose type the astrocytes, corresponding to Alzheimer type II glia, had swollen cytoplasm containing glycogen granules and focal aggregates of lipofuscin granules. Their nuclei contained bodies of simple and of complex types as well as conglomerates of glycogen granules without any capsules. The nuclear bodies of simple type were also observed in the nuclei of endothelial cells. It is concluded that these changes in the appearance of Alzheimer type II glia suggest reactive and defensive changes in the brain against ammonium ions, rather than being merely degenerative in nature.

Astrocytes↗
PubMedDate not supplied

Juvenile parkinsonism: a case with first clinical manifestation at the age of six years and with neuropathological findings suggesting a new pathogenesis.

A clinico-pathological study of a 39-year-old female with Juvenile parkinsonism was carried out. Although the clinical manifestations were consistent with parkinsonism, the pathological findings were significantly different. Pathological examination showed the lesion to be localized to the substantia nigra, the number of neurons to be abnormally low, the proportion of melanin-containing cells to be reduced, and a large number of immature cells to be present. No neuronal degeneration associated with gliosis or release of melanin granules, such as seen in Parkinson's disease, was observed. Neuropathological studies, including cytometry and comparison against normal controls in the distribution of melanin granules, suggested hypoplasia and poor neuronal maturation of the substantia nigra. Since neuromelanin is thought to be the result of normal dopamine metabolism, reduction of melanin-containing cells in this case suggests inadequate or abnormal dopamine metabolism. Thus, the clinical manifestation of parkinsonism in this case seems to be related to the small number of melanin-containing cells which implies the dopamine deficiency state.

Autopsy↗
PubMedDate not supplied

Adult type of neuronal ceroid-lipofuscinosis with retinal involvement.

A rare case of Kufs' disease with retinal lesions is reported in which the first symptom of visual disturbances later resulted in total blindness. Various neurologic symptoms and mental deterioration also developed. The total duration of the illness was 32 years. Neuropathologic examination showed extensive ballooned nerve cells filled with lipopigments in the CNS. In the retina there was a thinning with severe loss of rods, cones, and outer nuclear and outer plexiform layers. The remaining ganglion cells of the retina were also ballooned and accumulated with lipopigments. Histochemical and electron microscopic examinations disclosed that the lipopigments in the ballooned neurons of the CNS and the retina were identical with lipofuscin pigments.

Adult↗