Osteosarcoma of the thoracolumbar spine: total en bloc spondylectomy. A case report.
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Adolescent↗
Biomedical subjects
S Otsuka
Publications and source records attributed to S Otsuka.
Esophageal anisakiasis accompanied by reflux esophagitis.
A case with esophageal anisakiasis accompanied by reflux esophagitis is described. A 38-year-old man visited our hospital with complaints of heartburn and disturbance of food passage about seven hours after eating raw cuttlefish. The first esophagogastroscopy revealed an anisakis larva invading the squamocolumnar junction. Near the anisakis larva, a whitish exudate was demonstrated in the distal esophagus just proximal to the squamocolumnar junction. An anisakis larva was easily extracted from the esophagus by forceps. Reflux esophagitis with whitish exudative mucosal lesions and an area of linear erythema more than 5mm long were noted endoscopically 8 weeks after treatment with lansoprazole and cisapride. After six months the third endoscopic examination clarified that there was neither exudate nor erythema in the distal esophagus. Judging from the clinical course that he complained of newly experienced heartburn about seven hours after eating raw cuttlefish, and that whitish exudative mucosal lesions and an area of linear erythema did not disappear at three months after extraction of the anisakis larva. It was concluded that an anisakis larva enters the stomach first and then returns to the esophagus by gastroesophageal reflux.
Adult↗
[Clinicopathological features of transfusion-associated graft-versus-host disease].
The pathophysiology and clinical features of TA-GVHD are reviewed. Engrafted donor derived lymphocytes in TA-GVHD mainly target the immune system, i.e. myeloid and lymphoid as a result of recognition of "foreign" recipient transplantation antigens. The pathophysiology of acute GVHD has been described as a "cytokine storm" at the barrier of the immunobiological defence in the skin, liver, and intestine. TA-GVHD is mostly an acute syndrome, and predominantly associated with a pan-cytopenia, severe immunosuppression, a skin eruption, hepatitis, and gastrointestinal dysfunction, clinically manifested nausea, vomiting and diarrhea. The overall risk of TA-GVHD is unknown and is probably higher than the approximately 300-350 cases reported in the literature. TA-GVHD is often unrecognized in the setting of complex medical situations, where target organs are already dysfunctional. Furthermore, incomplete manifestations of the triad of GVHD may be present, or the syndrome may be mild or atypical. Finally, the potential diagnosis may be missed. We present an atypical case of fatal TA-GVHD in an immunocompetent diabetic patient after CABG operation, showing leukocytosis throughout the clinical course.
Aged↗
Molecular cloning of a cDNA encoding human ribosomal protein L39.
A cDNA clone encoding a human ribosomal protein L39 (hRPL39) was isolated through a random cDNA sequencing approach to a cDNA library constructed from a human colon carcinoma cell line of COLO 205. Although levels of hRPL39 mRNA were different in several cell lines including carcinoma cell lines from different tissues, they were shown not to be cell cycle-dependent in a human fibroblast cell line of TIG-1.
Amino Acid Sequence↗
Combined endoscopic clipping and injection sclerotherapy for esophageal varices.
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Adult↗
Protective effect of teprenone on blood flow and incidence of histologic lesions in rat gastric mucosa after hemorrhage and retransfusion.
BACKGROUND: The effects of teprenone (6,10,14,18-tetramethyl-5,9,13, 17-nonadecatetraen-2-one) on changes in gastric mucosal blood flow, adenosine triphosphate (ATP) content, and incidence of histologic lesions were evaluated in rat gastric mucosa after hemorrhage and retransfusion. METHODS: Teprenone (100 mg/kg) was administered orally once a day for 3 consecutive days. On the 3rd day hemorrhage was induced, withdrawn blood (retransfusion) was returned, and the above variables were determined. RESULTS: Teprenone significantly inhibited the decreases in blood flow and index of mucosal oxygen saturation (ISO2) during hemorrhage in the corpus and antral mucosa. However, no effect of teprenone was observed on systemic blood pressure and ATP levels after hemorrhage and retransfusion. Teprenone significantly (p < 0.05) decreased both the incidence of ischemic lesions and the increase in the severity of lesions after retransfusion in both mucosal regions. CONCLUSION: From these results, it is concluded that the protective effect of teprenone on blood flow was partly responsible for its inhibitory effect on the incidence of lesions in the rat stomach in this hypovolemic shock model, although the former effect might be not a direct effect on systemic vascular tone.
Adenosine Triphosphate↗
[The fellow eye in patients with retinal detachment associated with atopic dermatitis].
The fellow eyes of 13 cases of retinal detachment associated with atopic dermatitis were examined by binocular ophthalmoscope combined with scleral indentation. Breaks in the retina or pars plana were detected in 8 cases (62%); 2 of these eyes had asymptomatic retinal detachment. The most common location of these breaks was at the vitreous base symmetrical to the affected, symptomatic eye. Meticulous ophthalmoscopic examination is recommended for both eyes in patients with retinal detachment associated with atopic dermatitis.
Adolescent↗
[13C-acetate breath test for the measurement of gastric emptying rates].
Although acetaminophen (APAP) method is widely used to evaluate the gastric emptying rates of liquids in Japan, patients need to take a large dose of APAP. A scintigraphic technique requires the gamma camera. In this present state we try to search for an alternative method, which is easy to perform and noninvasive for the patient. 13C-acetate breath test and APAP method were performed at the same time in 59 patients after overnight fasting. The liquid test meal OKUNOS-A (200 ml, 200 kcal), contained APAP (20 mg/kg) and 13C-acetate 100 mg was orally administered to the patient. Breath sampling for 13CO2 measurements was obtained every 5 min up to 20 min and every 10 min up to 90 min. Blood sampling for plasma APAP concentration was collected 15, 30, 45, and 60 min after oral administration of the test meal. The time of 13CO2 peak excretion in 13C-acetate breath test was ranged from 50 to 70 min in 37 out of 59 patients. Plasma APAP concentration at 45 min in over 80 min group was significantly lower than in 50-70 min group. In contrast, that in under 40 min group was significantly higher. 13CO2 breath excretion at 30-40 min correlated with plasma APAP concentration at 45 min significantly. These results suggest that optimal sampling time of breath test is 20-40 min. In conclusion, 13C-acetate breath test is reliable as a qualitative analysis, easy to perform, and a noninvasive method without taking blood and radiation exposure for a measurement of gastric emptying rates.
Acetates↗
[Visual field defect following macular hole surgery].
We report three patients with inferotemporal visual field defect following pars plana vitrectomy for idiopathic macular hole. Two patients complained of the visual field defect early in the postoperative period, and one patient was asymptomatic but showed abnormalities in perimetry. The visual field defect remained unchanged during a follow-up study of 4 to 12 months. It is possible that inadvertent damage to the optic nerve associated with air/ fluid exchange or hyaloid membrane stripping caused the characteristic visual field defect.
Female↗
[Endoscopic treatment of early gastric cancer with laser and laserthermia using Nd : YAG laser].
As a therapeutic modality for early gastric cancer, endoscopic laser treatment is indicated in cases where the tumor is an intramucosal carcinoma, the macroscopic type is either I, IIa, or IIc(Ul(-)), and the diameter of the tumor is less than 10 mm. Type I tumors with less than 15 mm diameter and type IIa tumors with less than 20 mm diameter can be included in this indication. Depressed lesions should be treated carefully. Endoscopic laser treatment may be considered for patients who are not candidates for surgery or who refuse surgery.
Gastroscopy↗
[Percutaneous microwave coagulation therapy and endoscopic microwave coagulo-necrotic therapy for small hepatocellular carcinoma].
Recently, microwave coagulation has been in the spotlight for its local application on tumor necrosis with sufficient effects. We introduce here percutaneous microwave coagulation therapy (PMCT) and endoscopic microwave coagulo-necrotic therapy (endo. MCN) for small hepatocellular carcinoma.
Carcinoma, Hepatocellular↗
[Percutaneous ethanol injection therapy for small hepatocellular carcinoma].
Surgical resection is rarely indicated for hepatocellular carcinoma, because of its multiple lesions and often associated complication of liver cirrhosis. In 70-90% of patients who undergo radical operation, cancer will recur within 5 years after the surgery. Therefore, medical therapy plays an important role in the treatment for small hepatocellular carcinoma. Percutaneous ethanol injection therapy is thought to be the first choice, because of its excellent local control, preservation of liver function, and possibility of repeated use when necessary. We confirmed good long-term results of this therapy.
Carcinoma, Hepatocellular↗
[Endoscopic treatment of early gastric cancer with heat probe method].
The heat probe method, which was developed as an instrument for hemostasis, has a strong coagulating effect and can be applied to the treatment of early gastric cancer. Intramucosal, differentiated adenocarcinomas of the protruded type with less than 20 mm diameter were most effectively treated with the endoscopic heat probe method. As compared with laser or microwave, heat probe treatment is inexpensive and portable, and it can be used in patients who are not candidates for surgery or who refuse surgery.
Adenocarcinoma↗
A case of an intra-atrial tumor thrombus from hepatocellular carcinoma (HCC), first indicated by 67Ga-citrate scintigraphy.
We encountered a very rare case of an intra-atrial tumor thrombus from hepatocellular carcinoma (HCC). Conventional XCT and US gave evidence of HCC. In nuclear medicine studies performed incidentally, the first study with 99mTc-phytate liver scintigraphy showed 2 SOLs and evidence of chronic liver disease, and the second study with 67Ga-citrate scintigraphy demonstrated 2 hot lesions within the liver parenchyma, and also another unexpected hot area just above the left lobe of the liver, seemingly beyond the diaphragm. When echocardiography was performed, in addition to ECG, because the patient began to complain of dyspnea, an oblong mass lesion was detected within the right atrium. Reexamination with XCT and angiography clearly proved the existence of an intraatrial tumor thrombus. These results indicate the need for routine examination by echocardiography for HCC patients complaining of dyspnea.
Carcinoma, Hepatocellular↗
Intraorbital malignant lymphoma presenting with tumor stain on angiography--case report.
A 58-year-old male presented with a 1 month history of left retro-orbital pain and diplopia. Computed tomography demonstrated an isodense intraorbital tumor with slight homogeneous enhancement. Magnetic resonance imaging showed the tumor was isointensity on T1-weighted imaging, slightly high intensity on T2-weighted imaging, and slightly enhanced by gadolinium-diethylenetriaminepenta-acetic acid. Left external carotid angiography showed a tumor stain fed from the branches of the left internal maxillary artery. The tumor was partially removed. The histological diagnosis was malignant lymphoma. Tumor staining is rare in intraorbital malignant lymphoma and is not adequate for differential diagnosis of intraorbital tumors, so biopsy is essential.
Carotid Artery, External↗
Pulmonary metastasis of renal cell carcinoma resected sixteen years after nephrectomy.
A 50-year-old man underwent a left nephrectomy for renal cell carcinoma of the clear cell type in February, 1978. He was examined using computed tomography in September, 1993, and was found to have a small coin lesion in his right lung. A fine needle aspiration biopsy failed to disclose any tumor cells. He underwent a video-assisted thoracoscopic biopsy of the right lung in February, 1994, 16 years after his nephrectomy. The resected specimen contained a coin lesion measuring approximately 1 cm in diameter, and the lesion was microscopically diagnosed as a renal cell carcinoma of the clear cell type metastatic to the lung. The patient is doing well with no signs of re-recurrence six months after the resection of the metastatic lesion. To our knowledge, the time interval between his nephrectomy and resection of the metastatic lesion is the longest ever reported in Japan.
Biopsy↗
Trigeminal neuralgia: association with tentorial meningioma and persistent primitive trigeminal artery.
A rare case of trigeminal neuralgia caused by tentorial meningioma associated with a persistent primitive trigeminal artery (PTA) is reported. This case involved a 59-year-old female patient with a more than 6 month history of left trigeminal neuralgia. A left cerebello-pontine angle (CP angle) meningioma was found associated with a right PTA connecting the proximal portion of the cavernous internal carotid artery with the basilar artery, supplying the bilateral superior cerebellar arteries. The tumor was totally removed via the suboccipital approach, which relieved the pain completely. Since the combination of a CP angle meningioma and a PTA is quite rare in patients with trigeminal neuralgia, we have presented this case here.
Basilar Artery↗
Radioimmunodetection of cancer of gastrointestinal tract and liver metastasis with I-131 anti-CEA and I-131 anti-CA19-9 monoclonal antibody cocktail (IMACIS-1).
We evaluated the intravenous infusion of a cocktail of I-131 anti-CEA and anti-CA19-9 monoclonal antibody F(ab')2 (IMACIS-1) in patients with gastrointestinal neoplasm and liver metastases in order to assess its efficacy in detecting the presence of cancer. Seven patients with primary or recurrent gastrointestinal cancer in whom liver metastases were also detected were studied. Accumulation of radioactivity in the primary tumor was seen in only one patient. Visualization of the liver metastases was achieved in all patients. Thus detection of liver metastasis was better than in primary or recurrent tumors. While tumor visualization was most often seen in the 3 day image, optimal visualization of the tumor was seen at 5-7 days. There was no correlation between the serum concentration of CEA or CA19-9 and the visualization of tumors. Serum kinetics of I-131 IMACIS-1 showed biexponential components with a 1st phase T1/2 of 5.0 hours and 2nd phase T1/2 of 34.7 hours. The mean whole body (I-131) half-life determined from the whole-body scans was 1.95 days. The mean urinary excretion of I-131 in 7 days was 85%. This value agreed closely with total radioactivity retention detected by scanning. This series of studies demonstrated the potential utility of a cocktail of antibodies consisting of an anti-CEA and an anti-CA19-9 monoclonal F(ab')2.
Aged↗