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Biomedical subjects

S Osterberg

Publications and source records attributed to S Osterberg.

At least 19 recordsLinked to original sources

Variation of erythrocyte glutathione peroxidase activity in Finn sheep.

Erythrocyte glutathione peroxidase (GSH-Px) which was analysed on a flock of Finn sheep (266 sheep) showed variable activity despite the same diet and selenium intake. Mating experiments suggested that the GSH-Px activity was genetically determined. The low GSH-Px animals showed better performance as shown by a significantly reduced mortality rate of their offspring. Evidence of larger weight gain and wool production in the low GSH-Px sheep was obtained. The GSH-Px activity slightly decreased with age. The erythrocyte GSH-Px activity did not show much correlation with other genetical markers such as the potassium type, GSH type, haemoglobin type or sex. It is proposed that the low GSH-Px may represent an adaptation to low selenium intake.

Animals

Association between glutathione, haemoglobin and transferrin in finnsheep.

Haemoglobin (Hb) and transferrin (Tf) types were determined in 760 Finnsheep and correlated with the reduced glutathione (GSH) levels of packed erythrocytes. The gene frequencies of the two haemoglobin alleles A and B were: HbA = 0.748 and HbB = 0.252. Five transferrin alleles were found: A, B, C, D and E, with gene frequencies of 0.056, 0.226, 0.620, 0.075 and 0.023, respectively. The Hb B group had significantly higher GSH levels and lower haematocrit values than heterozygotes (Hb AB) and homozygote (Hb AA). There was no significant difference in GSH concentration among the haemoglobin types in lambs. Erythrocyte glutathione levels of Tf BC ewes were significantly higher than the levels in sheep with other transferrin types, whereas young lambs of Tf AB types had the highest GSH levels. The significance of these findings is discussed.

Alleles

Abnormal haemoglobin in Finnsheep.

An abnormal type of haemoglobin in one ewe and one of her four lambs of Finnish breed has been reported. This type of haemoglobin in Finnsheep seems to be similar to HbC reported in some Norwegian breeds and in anaemic Merino sheep.

Animals

Variation of glutathione levels in Finnsheep.

Blood glutathione was measured in Finnsheep. Inheritance data show that the two types of GSH concentrations were under independent genetic control. GSH levels were found to be associated with potassium levels and reproduction in Finnsheep.

Animals

Urinary polyamine excretion during the menstrual cycle.

Urinary polyamines were measured by a fluorometric thin-layer chromatographic technique in samples collected daily throughout a single menstrual cycle by each of 13 healthy women. Polyamine excretion fluctuated considerably, but excretion of putrescine, spermidine, and spermine combined was consistently greatest during menstruation, sometimes extending into the early follicular phase of the cycle. Enhanced excretion of polyamines was also noticed in many individuals at the approximate time of ovulation.

Adult