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Biomedical subjects

S Ono

Publications and source records attributed to S Ono.

At least 577 records · Page 32Linked to original sources
PubMed1989

[Sequential changes of the cardiomyopathy in Duchenne muscular dystrophy by 201Tl myocardial SPECT].

201Tl myocardial SPECT was performed to evaluate cardiomyopathy in Duchenne type of progressive muscular dystrophy (DMD). Follow up SPECT images of the same patients were also obtained about 1 year after the first scan. Cases subjected to study were 10 DMD. At the first study the hypoperfusion area of the left ventricular muscle was observed in 6 cases (60%) out of 10. At the second study the hypoperfusion areas became wider and lower in 4 out of 6 cases (66.7%). The new hypoperfusion area which was not demonstrated at the first study was observed at the second study in one case of these cases. These results suggested that the positive rate of cardiomyopathy in DMD by 201Tl myocardial SPECT was high, and 201Tl myocardial SPECT is a useful examination to detect the change of myocardial damage in DMD.

Adolescent↗
PubMed1989

[Hepatocellular carcinoma--a comparative study of MR imaging and angiography].

We used magnetic resonance imaging (MRI) at 0.2 T and angiography to evaluate hepatocellular carcinoma (HCC) in 43 patients who had not received therapy. Tumor detection rate by MRI was 84%, T2-weighted spin echo imaging being the best detection method, though one case could only be detected by T1-weighted imaging (Inversion Recovery method). The signal intensity of the tumor relative to the surrounding liver parenchyma was studied using MRI, and tumor staining using angiography. Where there was a high signal intensity in the T2-weighted spin echo images there was a corresponding tendency for tumor staining to be marked. MRI demonstrated the inner structure--which resembles random high-intensity threads on a lower-intensity background--of hypervascular tumors. Tumors with capsules appeared with the capsule clearly delineated irrespective of the signal intensity of the tumor itself.

Adult↗
PubMed1989

Exposure of newborn mice to adenosine causes neural crest dysplasia and tumor formation.

In the first part of this paper, we show that intraperitoneal injection of adenosine into newborn mice causes multiple neural crest tumors, neural crest hyperplasia, and heterotopic melanin pigmentation. In the second part, we review published data to propose (1) that microtubule proteins, phosphorylated through the action of calmodulin-dependent kinase and cyclic adenosine monophosphate and the adenosine A2 receptor of neural crest cells, may participate in neurotransmission and (2) that at least some neural crest tumors may be associated with disorders of neurotransmission in embryonic neural crest cells.

Adenosine↗
PubMed1989

[Respiratory regulations of pulmonary vagal nerves under hypercapnic conditions; effects of J-receptor].

We studied ventilatory responses under hypercapnic condition in 9 lightly anesthetized dogs, using a vagal nerve cooling technique. One side of the cervical vagosympathetic trunks of dogs were previously severed, and a copper cooler was attached to the other side. When the cervical nerve was cooled below 7 degrees C, the Hering-Breuer inflation reflex ceased. We found that when the vagal nerve was not cooled or cooled to 7 degrees C, the respiratory frequency increased significantly in relation to hypercapnic gas inhalation. However, the increment of respiratory frequency was reduced by bilateral cervical vagotomy. We concluded that the J-receptor is responsible for the increase in respiratory frequency under hypercapnic gas inhalation.

Animals↗
PubMed1989

Different effect of prostaglandin E2 on B-cell activation by two distinct B-cell differentiation factors, B151-TRF1/IL-5 and B151-TRF2: selective inhibition of B151-TRF2-induced antibody response through increases in intracellular cyclic AMP levels.

Effects of prostaglandin E2 (PGE2) on murine B-cell activation induced by two distinct B-cell differentiation factors, B151-TRF1/IL-5 and B151-TRF2, were examined. A final differentiation of unprimed B cells into IgM-producing cells induced by B151-TRF2 was markedly inhibited by PGE2 at physiological concentrations (around 10(-8) M), whereas B151-TRF1/IL-5- induced antibody responses of unprimed as well as activated B cells were not affected by PGE2, even at 10(-6) M. B-cell responses induced by B151-TRF2-like factors from autoimmune-prone MRL/lpr mice were also inhibited by PGE2. Biphasic increases in intracellular cyclic AMP (cAMP) levels were induced by culturing B cells with 10(-6) or 10(-8) M PGE2: rapid increases within 8 min and delayed increases around 16 hr. The direct addition of dibutyryl cAMP to cultures of B cells resulted in marked inhibition of antibody responses when stimulated with B151-TRF2 but not with B151-TRF1/IL-5. The B151-TRF2-induced antibody responses were also inhibited by cAMP-elevating reagents such as forskolin, cholera toxin and theophylline. Furthermore, 2'.5'-dideoxyadenosine, which is an inhibitor of adenylate cyclase, prevented the PGE2-mediated cAMP accumulation in unprimed B cells as well as the PGE2-mediated inhibition of B151-TRF2-induced B-cell responses when added at the initiation of culture. These results suggest that PGE2 inhibits B151-TRF2-induced antibody responses through the activation of adenylate cyclase and subsequent accumulation of intracellular cAMP, whereas B151-TRF1/IL-5-responsive B cells are resistant to the inhibitory effect of PGE2 and cAMP.

Adjuvants, Immunologic↗
PubMed1989

[A case of Sjögren-Larsson syndrome with peripheral nerve involvement].

A case of Sjögren-Larsson syndrome (SLS) with peripheral nerve involvement was described. A patient was a 37-year-old man with marked mental retardation who had ichthyosis since several months of age. He developed spastic gait at age 20 and noticed muscle weakness and atrophy in lower extremities at age 30. On examination, electromyogram showed neurogenic changes with polyphasic motor unit potentials of high amplitude and long duration, and motor and sensory conduction velocities were slightly decreased in lower extremities. Muscle biopsy specimens of the left quadriceps showed grouped atrophy and pyknotic nuclear clumps, suggestive of neurogenic changes. Left sural nerve biopsy showed decreased number of myelinated fibers. On electron microscopy, some myelinated fibers revealed proliferation of the organelles in axons with disruption of the myelin sheath, and glycogen granules in Schwann cell cytoplasm. Unmyelinated fibers showed no reduction in the density, but accompanied numerous collagen pockets and Schwann cell cytoplasmic processes arranged in many stacks, suggesting the presence of some degenerative changes. With the present findings at peripheral level and a review of the literature, we may assume that SLS has extensive disorders of the ectodermal tissues including the peripheral nerve as well as the skin and the central nervous system.

Adult↗
PubMed1989

[Effect of vasopressin on rabbit hepatic energy metabolism evaluated using in vivo P-31 magnetic resonance spectroscopy].

Changes in metabolic state of rabbit livers after administration of vasopressin (10 mU/kg/min d.i.v.) were evaluated using in vivo P-31 magnetic resonance (MR) spectroscopy. Targets were nine normal control rabbits and eight with chronically carbon tetrachloride-damaged livers. A 2.0 Tesla whole-body MR imager was used for measurement. After administration of vasopressin, liver spectroscopy showed a mild ischemic pattern. The inorganic phosphate peak increased statistically significantly (p less than 0.05) both in the normal control group and in the damaged-liver group (20% and 16% above base line value respectively). In the normal control group, there was a statistically significant decrease (p less than 0.05) in the ATP peak to 18% below the base line value while the PME (phosphomonoester) peak increased slightly (about 10%); there was little change in the damaged-liver group. It was thought that the difference between the two groups was due to differences in blood flow mechanism and liver metabolism. Magnetic resonance spectroscopy was considered to be useful in studying the detailed changes in metabolic state of rabbit liver after administration of vasopressin.

Animals↗
PubMed1989

[Application of transendoscopic Nd-YAG laser to stenosis caused by unresectable carcinoma of the alimentary tract].

Clinical and pathological studies were performed on the efficacy of transendoscopic Nd-YAG laser irradiation to stenosis by unresectable carcinoma of the alimentary tract, and the following conclusions were obtained. Nd-YAG laser was irradiated with 30-40W, total energy 3,000-12,000J, to carcinoma of 8 cases of the esophagus, 4 cases of the stomach, 7 cases of recurrence at gastric anastomosis site and 4 cases of the large intestine, and it evaporated and reduced tumor to relieve of stenosis. The patients's quality of life was remarkably improved. Pathological study on biopsied specimens at the site of irradiation revealed no residual viable cancer cell within at least 6mm depth from the surface of carbonization layer. No perforation, no massive bleeding, no pain were recognized both during and after irradiation.

Aged↗
PubMed1989

[A case of polymyalgia rheumatica with cytoplasmic bodies].

A 63-year-old man with polymyalgia rheumatica (PMR) with cytoplasmic bodies (CB) in biopsied muscle was reported. He was referred to our hospital in June 1988 because of myalgia of four extremities. The ESR was 114 mm/hr and the serum CPK level was normal. Needle EMG and nerve conduction velocities showed normal findings. On light microscopic examination in biopsied muscle, the inclusion bodies which appeared on HE stained sections as deep reddish masses were present in 10% of all fibers. By electron microscopy the core of the bodies consisted of a dense tangle of thin filaments which were intermixed with granular material. Around the core a network of irregularly or radially oriented filaments was observed. These bodies were identified with cytoplasmic bodies. Since there has been no previous report of PMR with CB, our case is important to discuss the relationship between the pathogenesis of PMR and CB.

Biopsy↗
PubMed1989

[Possible involvement of vascular endothelium-derived relaxing factor induced by platelet-activating factor (PAF) on human pulmonary artery after contraction in vitro].

We studied the effects of platelet-activating factor (PAF) on human pulmonary vascular smooth muscle in vitro. 10(-6) M PAF elicited slight contractions in 2 of 7 endothelium-denuded arterial strips, but did not elicit distinct contractions or relaxations in the other strips. After incubation with PAF at 10(-7) M, the contractions of pulmonary vascular smooth muscle induced by histamine and prostaglandin F2 alpha were significantly decreased. Preincubation of 10(-3) M indomethacin did not affect the inhibitory effects of PAF, but these disappeared with removal of endothelium. These results suggest that the inhibitory effects of PAF on human pulmonary vascular smooth muscle contractions may appear not through the cyclooxygenase products but the endothelium-derived relaxing factor.

Female↗
PubMed1989

[Evaluation of the relationship between esophageal varices and azygos vein using percutaneous transhepatic cine-portography].

To evaluate the relationship between esophageal varices and the azygos vein--which is generally considered to drain the major part of the esophageal variceal blood--we examined 36 patients with portal hypertension using percutaneous transhepatic cine-portography. The patients were classified into three groups (azygos, cervical and combined) according to the amount of blood to be considered drained by the azygos vein. Eighteen patients (50%) fell into the azygos type group, five (14%) into the cervical, and 13 (36%) into the combined. Highly developed esophageal varices were recognized endoscopically in all patients in the combined and cervical type groups while some of the patients in the azygos type group had less well developed varices. In the azygos type group, there was a tendency for the varices to be increasingly severe the higher the part of the azygos vein they drained into. Because it helps us to fully comprehend the significance of the azygos venous blood flow and the occasionally uncertain effect of endoscopic injection sclerotherapy for esophageal varices, it is important to evaluate the drainage route of esophageal varices in vivo and in detail. Percutaneous transhepatic cine-portography is the useful method for this purpose as it enables us to visualize even the most minute blood stream.

Aged↗
PubMed1989

[Pulmonary hemodynamics during mild exercise in COPD].

The effects of mild exercise on pulmonary hemodynamics and ventilatory responses in COPD were studied. Six patients with FEV1% less than 70% received 20 watt exercise tests by cycle ergometers for 5 minutes. Changes in hemodynamics and ventilation were observed before and during exercise. Nine patients with an FEV1% of more than 70% also received exercise tests as controls. There were no different in changes in respiratory frequency, tidal volume and minute ventilation between control and COPD group. However, the mean pulmonary arterial pressure were higher in the COPD group than in the control group before exercise. Moreover increments of mean pulmonary arterial pressure by exercise were also greater in COPD group. It was concluded that hemodynamics in COPD are much more influenced by mild exercise than in healthy subjects.

Adult↗
PubMed1989

[A case of Creutzfeldt-Jakob disease followed up by N-isopropyl-[123I]-p-iodoamphetamine and 99mTc-hexamethylpropyleneamine oxime SPECT].

N-isopropyl-[123I]-p-iodoamphetamine (123I-IMP) and 99mTc-hexamethylpropyleneamine oxime (99mTc-HM-PAO) SPECT were performed in a 66 yrs-old female patient with Creutzfeldt-Jakob disease (CJD). The decreased accumulation of both radiopharmaceuticals, which localized initially in the focal regions and progressed eventually to the whole brain, were observed in the early stage of CJD, when no abnormal findings were obtained on X-CT. Although the redistribution of 123I-IMP was recognized in the relatively early stage in which the accumulation was significantly decreased, it disappeared with the progression of the disease. The accumulation of both radiopharmaceuticals which decreased remarkably in the early stage of CJD was sustained in low level during the chronic stage. The accumulation ratio of 99mTc-HM-PAO, after second examinations, to that on first SPECT was lower than those of 123I-IMP. It was suggested, as this cause, that the difference of the accumulation mechanism of both agents might be concerned. Thus, it is interested to follow up a patient with CJD by using 123I-IMP and 99mTc-HM-PAO SPECT, and this modality will provide a useful information to clarify the pathogenesis of CJD.

Aged↗