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Biomedical subjects

S Olsen

Publications and source records attributed to S Olsen.

171 records · Page 10Linked to original sources
PubMedDate not supplied

Knowledge of menopause and hormone replacement therapy use in low-income urban women.

Hormone replacement therapy (HRT) can have significant long-term health benefits in postmenopausal women, yet rates of HRT use are low, especially in low-income urban women. Previous research has revealed that knowledge of menopause is a key predictor of HRT use in this population. A descriptive cross-sectional survey of 215 perimenopausal and postmenopausal low-income urban women was carried out to characterize knowledge of menopause and HRT and factors associated with knowledge level. Sociodemographic characteristics, patterns of HRT use, and knowledge about menopause and HRT were collected through a structured interview. Results revealed a general lack of knowledge about menopause and HRT, particularly relative to heart disease and the role of HRT in prevention. Major independent predictors of increased knowledge (R2 = 0.31) were having talked with a healthcare provider about HRT, having at least a high school education, and being less than 60 years of age. These findings emphasize the key role of providers in educating this vulnerable population about menopause and HRT and the potential subsequent impact on HRT use.

Cross-Sectional Studies↗
PubMedDate not supplied

Pyelorenal backflow in normal and ischemic rabbit kidneys.

Pyelorenal backflow during retrograde pyelography was studied in 68 kidneys of anesthetized rabbits. Thirty-three of the experiments were performed during or shortly after temporary renal arterial clamping. Pyelosinous backflow was observed in 67 and pyelovenous backflow in 65 of the 68 kidneys, occurring at an average intrapelvic pressure of 70 mmHg. This was true in intact kidneys and during arterial occlusion. Intrarenal backflow--intrusion of contrast material into the renal parenchyma--could be produced in only one of 35 experiments on intact kidneys, and occurred at an intrapelvic pressure of 119 mmHg. During arterial clamping, intrarenal backflow was observed in eight of nine experiments, occurring at intrapelvic pressures of about 70 mmHg. After removal of the clamp, intrarenal backflow was less frequent with shorter periods of arterial clamping and longer time between restoration of arterial flow before pyelography. Subcapsular extravasation of the medium with total blurring of the kidneys shadow and a prompt fall in intrapelvic pressure was the ultimate result of prolonged and extreme overdistension of the renal pelvis. It occurred at an average intrapelvic pressure of 80 mmHg. Histologic examination revealed tears in the fornix of the pelvic cavity in cases with pyelosinous backflow. If intrarenal backflow was present, there were tears leading from the pelvic cavity into the renal parenchyma. Supplementary experiments using a contrast material that could be demonstrated histologically (barium sulfate with gelatin) showed that the contrast filled the intertubular capillaries and venules. There was no evidence of backflow through the canalicular route.

Animals↗
PubMedDate not supplied

Perfusion--fixation of human kidneys for ultrastructural analysis.

Surgically removed human kidneys were fixed by vascular perfusion to improve the preservation of renal tissue and, in particular, the proximal tubules for electron microscopic analysis. Fifty kidneys with various pathologic changes were perfusion-fixed with glutaraldehyde under pressure control immediately after nephrectomy. A Tyrode solution containing a spasmolytic drug initiated the perfusion. The results demonstrate that large volumes of ultrastructurally well-preserved kidney tissue can be obtained in normal (nontumorous) parts of tumor kidneys as well as in kidneys with chronic nephropathy. Several factors improved the quality of fixation: (1) start of perfusion-fixation within 15 min after clamping of the renal vessels, (2) careful handling of the kidney during nephrectomy, (3) simultaneous clamping of the main renal vessels, and (4) employment of a spasmolytic drug. In comparison with tissue from immersion-fixed renal biopsies, perfusion-fixed kidneys represented an improved basis for ultrastructural investigations of normal or pathologically changed human kidney tissue.

Histological Techniques↗
PubMedDate not supplied

Pain measurement. An overview of two commonly used methods.

Two pain-measurement tools in particular have gained widespread acceptance by clinicians who work in the area of pain management: the visual analogue scale and the McGill Pain Questionnaire. The purpose of this paper is to describe briefly both of these methods and to consider some of their strengths, weaknesses, and applications.

Humans↗
PubMedDate not supplied

[Congenital atrioventricular block--intrauterine diagnosis and neonatal pacemaker treatment].

A complete fetal heart block was diagnosed in 29 weeks gestation by means of 2-dimensional and M-mode echocardiograms and by analyzing the combined Doppler effect of atrial and ventricular movements. Because of increasing fetal ascites and edema, Digoxin treatment is given from 31 weeks gestation until birth. 30 hours postnatal the child develops congestive heart failure which disappeared completely after pacemaker treatment. We stress the importance of early diagnosis with possibility of prenatal treatment and optimal planning of delivery in cooperation between obstetrician and pediatric cardiologist.

Adult↗
PubMedDate not supplied

Successful treatment of a cardiac angiosarcoma with combined modality therapy.

The patient was a 34-year-old man with a primary angiosarcoma of the heart. Initial admission was for cardiac tamponade. He was treated with preoperative chemotherapy and radiation therapy and then underwent orthotopic heart transplantation. The patient had an uneventful postoperative recovery, received two postoperative regimens of chemotherapy, and, at 33 months after transplantation, had no evidence of recurrence or metastasis. We propose that a more aggressive management of these patients with difficult conditions is warranted.

Adult↗