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Biomedical subjects

S Okuda

Publications and source records attributed to S Okuda.

At least 379 records · Page 21Linked to original sources
PubMed1977

Effect of prolonged administration of gastrin on experimental carcinogenesis in rat stomach induced by N-methyl-N' -nitro-N-nitrosoguanidine.

The effects of gastrin on gastric acid secretion and on the incidence of gastric carcinoma induced by N-methyl-N'-nitro-N-nitrosoquanidine were investigated in rats. At Week 50 after the start of the experiment, it was found that prolonged administration of gastrin after treatment with N-methyl-N'-nitro-N-nitrosoquanidine resulted in a significant increase in gastric acid secretion and a significant reduction in the incidence of adenocarcinomas of the glandular stomach. The administration of gastrin did not influence the histological appearance of the few gastric adenocarcinomas that did develop.

Adenocarcinoma↗
PubMed1976

Gastric ulcers in the fundic gland area.

Gastric ulcers have been thought to occur only in the pyloric gland area. However, endoscopic examinations using the Congo red test showed that 18 of the ulcers examined (7.8%) were surrounded by an acid-secreting area, and so were in the fundic gland area. Histological examination of specimens obtained by gastrectomy also showed that five of the lesions examined (4.5%) were located in the fundic gland area. Ulcers in the fundic gland area were found most frequently in the angle and lower gastric body, adjacent to acid-secreting boundary. These ulcers were associated with little or no fundal gastritis, whereas ulcers in the pyloric gland area were usually associated with moderate or severe fundal gastritis. Unlike ulcers of similar depth in the pyloric gland area, ulcers surrounded by normal fundic mucosa healed rapidly and completely. No recurrence of these ulcers was seen in a 1-year endoscopic follow-up period.

Adult↗
PubMed1975

Location, healing, and recurrence of gastric ulcers in relation to fundal gastritis.

The influence of fundal gastritis on the location, healing, and recurrence of gastric ulcers was studied by the endoscopic Congo red test. Results indicated a close correlation between the location of ulcers and the extent of fundal gastritis. In general, ulcers were more proximal when fundal gastritis was more severe. Of the ulcers examined, 62.5% of those not associated with fundal gastritis failed to heal, whereas 85.7% of those associated with severe fundal gastritis healed within 3 months. The presence of severe fundal gastritis was associated with a high rate of recurrence of gastric ulcers.

Gastric Mucosa↗
PubMed1975

Intramural injection of ethanol under direct vision for the treatment of protuberant lesions of the stomach.

The experimental production of gastric ulcers in dogs by subnucosal injection of ulcerogeic agents is described. The most satisfactory agent tested was 95% ethanol, because it produced immediate changes in the mucosa which delineated the size of the ulcer. The depth of ulceration could be controlled and the ulcer healed readily. Using this technique of ulcer formation, treatment of protuberant gastric lesions was attempted. Eradication of the pedunculated and narrow-based polyps in stomach was almost totally successful by injection into the base. Wide-based lesions, including atypical hyperplasia and the elevated type of early gastric cancer, were also completely eradicated in 96% of the treated cases. There have been no complications. An initial assessment of the practicality of this method in poor risk patients is presented.

Acetates↗
PubMed1970

Membrane modifications in nutritionally induced filamentous Escherichia coli B.

Nutritionally induced filamentous cell forms of Escherichia coli B were examined for their morphological and biochemical lesions. The filamentous forms showed no significant alteration in total DNA concentration, RNA synthesis, ability to form beta-galactosidase in response to isopropylthiogalactoside, or insensitivity to actinomycin D as compared to the normal cell form. The filamentous cells showed a marked decrease in the ability to incorporate N-acetylglucosamine-UL-(14)C into a phenol-soluble glycoprotein fraction relative to the normal cell form or relative to strain E-26 of E. coli grown in the filament-inducing medium. The filaments yielded an envelope-specific phenol-soluble protein fraction markedly reduced in or lacking three proteins as determined by acrylamide gel electrophoresis. Amino acid analysis, and chemical and enzymatic treatments of the envelope-specific phenol-soluble proteins showed striking differences between the fractions obtained from normal and filamentous cells. Electron microscope studies of divalent cation-induced aggregates of the envelope proteins showed different aggregation patterns dependent upon the cell form yielding the protein fraction.

Amino Acids↗