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Biomedical subjects

S Okazaki

Publications and source records attributed to S Okazaki.

At least 109 records · Page 6Linked to original sources
PubMed1983

The effects of diffusion and ultrafiltration on cardiac output and organ blood flows.

The effects of diffusion and ultrafiltration on cardiac output (CO) and organ blood flow (BF) in the uraemic dog were studied by a modified microsphere technique. In the diffusion phase of sequential therapy, a decrease in mean arterial pressure (MAP) and total peripheral resistance (TPR) was noted despite no change in circulatory plasma volume (CPV) and CO. In the ultrafiltration (UF) phase, MAP recovered with an increase in TPR despite the decrease in CPV and CO. Muscle vascular resistance increased in UF phase but not in the diffusion phase. The results suggest that the decrease in CPV through UF resulted in CO decrease, but that the compensation mechanism for the decrease is impaired by diffusion.

Animals↗
PubMed1982

Increased 125I-labelled concanavalin A binding to erythrocytes in diabetes mellitus.

Percentage binding of 125 I-labelled concanavalin A to erythrocytes in diabetic patients was significantly higher than that in normal subjects (12.2 +/- 2.8 versus 8.1 +/- 1.8%, mean +/- SD, p less than 0.001). Insulin-dependent diabetic patients showed significantly higher concanavalin A binding than non-insulin-dependent diabetic subjects (15.0 +/- 1.4 versus 11.4 +/- 2.5%, p less than 0.01). There was a highly significant correlation between percentage binding of 125I-labelled concanavalin A and glycosylated haemoglobin.

Adult↗
PubMed1982

Sequential morphological studies of the esophageal carcinoma of rats induced by N-methyl-N-amylnitrosamine.

N-Methyl-N-amylnitrosamine was given to male Wistar rats in the drinking water at a concentration of 0.003% for 8 weeks. Three rats were autopsied weekly from the first to the 25th week. The stages of hyperplasia, dysplasia and squamous cell carcinoma in the esophagus were chronologically observed. Hyperplasia and dysplasia were found by the 6th week and continuously observed until the end of the experiment. Early squamous cell carcinomas were found in the 13th week. They showed endophytic or exophytic growths. Histologically, the endophytic growths were well-differentiated squamous cell carcinomas and the exophytic growths were poorly-differentiated. Advanced carcinomas were first found in the 15th week and were almost well-differentiated. Carcinomas were not found in papillomas. The incidence of carcinomas increased with time, being 9 out of 15 rats (60%) in the final 21st through 25th weeks. Lymph node metastasis was found in one rat, killed at the 24th week.

Animals↗
PubMed1981

Insulin binding to erythrocytes in diabetes mellitus.

Insulin binding to erythrocytes was studied in diabetic patients. Insulin binding was lower in untreated diabetics and diabetic patients treated with diet or insulin than in normal subjects. Binding variation was mainly due to decreased binding site concentration in untreated and insulin-treated patients, and to lowered insulin binding site affinity in diet-treated patients. Several patients treated with hypoglycemic agents showed higher insulin binding due to increased binding site concentration. Insulin binding to erythrocytes may not always reflect the insulin binding status of insulin sensitive tissues.

Diabetes Mellitus↗
PubMed1978

A patient with repeated syncopal attacks after using isosorbide dinitrate.

The case of a patient with repeated attacks of collapse induced by sublingual isosorbide dinitrate is reported. The patient was an 81 year-old female who was admitted to Yura Hospital because of attacks of precordial pain. Several minutes after the sublingual administration of isosorbide dinitrate (10 mg) for an anginal attack, she developed a sensation of general weakness, and thereafter because unconscious. Arterial blood pressure fell and became unmeasurable. Electrocardiograms recorded during the syncopal attack showed sinus tachycardia and significant elevation of ST-segment in right precordial leads. In response to a drip infusion of noradrenaline, arterial blood pressure returned to normal with recovery of consciousness. Two similar syncopal attacks induced by sublingual isosorbide dinitrate occurred in the next three days. These attacks were not due to augmentation of the vagal reflex. Decrease of venous return probably was the primary etiological factor.

Aged↗
PubMed1977

A case report of primary hepatic carcinoma with prolonged HB virus infection and mono-clonal gammopathy.

A case of alpha-feto protein (AFP) positive hepatic cell carcinoma has been presented in which the appearance of a mono-clonal gammopathy can be explained by persistent infection with HB virus (HBV). The patient, a fifty year old male, developed acute jaundice with hepatitis in July, 1952, and died of an hepatic cell carcinoma in December, 1973. The interest of this case lies in the fact that during the seven months prior to be patient's demise, a mono-clonal gammopathy of IgG (L type), together with positive titeres for HBs Ag (adr) and AFP, was demonstrated.

Carcinoma, Hepatocellular↗