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Biomedical subjects

S Oi

Publications and source records attributed to S Oi.

At least 109 records · Page 6Linked to original sources
PubMed1985

Atresia of the foramen of Monro resulting in severe unilateral hydrocephalus with subfalcial herniation and infratentorial diverticulum.

A case of severe unilateral hydrocephalus associated with ventricular diverticulum and subfalcial herniation secondary to likely atresia of the foramen of Monro is presented. Both atresia of the foramen of Monro and ventricular diverticulum are rare conditions in hydrocephalus. The case presented here is the third reported case with both unique entities.

Cerebellar Diseases↗
PubMed1985

[A huge intraspinal teratocarcinoma associated with an arachnoid cyst in a child].

The authors report a 11-year-old girl with a huge intraspinal malignant teratoma associated with spinal arachnoid cyst. At seven year of age, suprasellar tumor was diagnosed and the patient received radiation therapy for tumor bed with total dose of 4,225 rads. As the result, marked decrease of the size of tumor was seen by follow-up CT scan. Serum alphafetoprotein (AFP) and human chorionic gonadotropin (HCG) level were at 51ng/ml and 31IU/l when total dose of 2,000 rads were over, and they decreased to 3ng/ml and 6.6IU/l at the dose of 4,225 rads respectively. The histology of the suprasellar tumor was unverified. She was discharged without any neurological deficits. For next 24 months, she received intrathecal administration of Methotrexate by repeated lumber puncture in 14 times. She remained intact neurologically. At eleven years of age, four years later, she started complaining of the right leg pain. On the examination, hypesthesia in the L distribution and stiff neck with positive straight leg raising test were observed. Urinary and bowel function were intact. CT scan of the head revealed residual of the suprasellar tumor but the size of the tumor was unchanged. Myelography showed complete block at the level of L. Laminectomy at L was performed and brownish cyst was found in the intradural space. Aspiration of cyst content and cyst wall resection were carried out. Histology of the cyst membrane was arachnoid and spinal arachnoid cyst was diagnosed. The postoperative course was uneventful until 13th postoperative day, when acute progressive paraparesis and numbness of bilateral toes were seen.(ABSTRACT TRUNCATED AT 250 WORDS)

Arachnoid↗
PubMed1985

[Brain tumors in infants and children--factors affecting prognosis, (Part-3). Mode of metastasis and prognosis in medulloblastoma].

Brain tumors in infants and children are different from those in adults in type and location of tumor as well as accompanying complication. Given this fact, and the fact that these patients are under development, careful consideration is required for determination of treatment planning. Thus, we have investigated the curative results of brain tumors in infants and children and factors effecting prognosis. In this study, medulloblastoma which is one of the most malignant pediatric brain tumors was analyzed in 64 cases in light of mode of metastasis and prognosis. Among those cases, there were 23 cases which were diagnosed to have metastasis or infiltration of tumor from the original site of the fourth ventricle. As mode of the cerebrospinal fluid circulation, 6 intracerebral solitary metastasis, 1 entraspinal cord metastasis, 1 intraperitoneal metastasis via shunt and 7 generalized metastases involving bone in 5, lymphnodes in 2 and liver, spleen, kidney, lung and peintoneal cavity in 1 respectively. The survival rate in those 23 cases with tumor metastasis or infiltration was 63.6% in one year, 28.6% in two years and 11.8% in five years and the average survival year was 8.1 months in cases who died of these tumor metastasis. Six of them had tumor metastasis with in 6 months after the initial treatment(s). There was no significant correlations in rate or occurrence of tumor metastasis between group of total resection and of partial resection nor group of whole neuro-axis radiation and of local radiation.(ABSTRACT TRUNCATED AT 250 WORDS)

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

Purification and some properties of beta-transglycosylase of Trichoderma longibrachiatum.

A beta-transglycosylase was purified to a homogeneous state from the extract of a wheat bran Koji culture of Trichoderma longibrachiatum by column chromatography. The purified enzyme showed a typical disproportionation reaction with cellopentaose as the substrate, producing a high molecular component (a water-insoluble glucan). The enzyme showed neither cellulase nor beta-glucosidase activity. The reaction was optimal at pH 6.0 and 37 degrees C. The molecular weight of the enzyme was estimated to be 11,000 by gel filtration using a TOYOPEARL HW-55F column. The amount of the glucan synthesized by the enzyme increased with prolonged incubation in a reaction with cellopentaose, and soluble cellooligosaccharides, such as cellobiose, cellotriose, cellotetraose, and cellohexaose, were also produced. No glucose was produced in the reaction even when it was carried out for a long time. The total number of molecules (cellooligosaccharides) in the reaction mixture remained at the initial substrate level during the entire reaction. The beta-transglycosylase proved to be a specific transferase showing transfer activity of glucosyl, cellobiosyl, and cellotriosyl moieties from one cellopentaose to an acceptor molecule from cellopentaose upwards with almost 100% efficiency.

Chemical Phenomena↗
PubMed1983

Physiological activity of warburganal and its reactivity with sulfhydryl groups.

Warburganal, a unique dialdehyde sesquiterpene isolated from East African Warburgia plants, showed a strong antifungal activity. However, this growth inhibition in Saccharomyces cerevisiae was reversed with L-cysteine. In addition, warburganal inhibited the alcoholic fermentation of S. cerevisiae while L-cysteine reversed this inhibition. When alcohol dehydrogenase, a sulfhydryl enzyme, was incubated with warburganal, the enzyme activity decreased with time. The decrease was more rapid at alkaline pH. L-Cysteine prevented this enzyme inhibition by warburganal but could not restore the enzyme activity lost already due to warburganal. Warburganal lost its characteristic ultraviolet absorption spectrum in the presence of L-cysteine. The change in absorbance was favored at alkaline pH, indicating Michael reaction type addition of L-cysteine to warburganal. Based on these observations, a variety of physiological activities due to warburganal appear to result from its irreversible reactivity with sulfhydryl groups.

Alcohol Oxidoreductases↗
PubMed1983

[Brain tumors in infants and children--factors affecting prognosis. (2) Location and prognosis of astrocytoma].

Brain tumors in infants and children are different from those in adults in type and location of tumor as well as accompanying complications. Given this fact, and the fact that these patients are under development, careful consideration is required for determination of treatment planning. Thus, we have investigated the curative results of brain tumors in infants and children and factors affecting prognosis. In this study, astrocytoma which is most frequently seen in infants and children was analyzed in 181 patients. One hundred forty three of them were diagnosed as benign astrocytoma; and the other 38, as malignant astrocytoma or glioblastoma. In respect of location, supratentorial tumors were seen in 73 patients, while subtentorial tumors occurred in 61; nine tumors infiltrated into both regions. The 5-year survival rate of benign astrocytoma was 50%, compared with 6.3% in malignant astrocytoma. As for relations to location of tumor, 66% of tumors which infiltrated into the supratentorial and subtentorial regions were malignant, and the prognosis was poor: the 5-year survival rate was 14.2%. The 5 year survival rate of subtentorial tumors was 38.9%, whereas that of supratentorial tumors was 57.6%. Analysis by age revealed that malignancy increased in proportion to age over 12 months after birth; between the ages of one and six years, the incidence of malignant tumors was 9% and the 5-year survival rate was 48%, while between the ages of 12 and 16, the rates were 29% and 14%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1982

[Transsphenoidal Microneurosurgery. Part 4: Neuroophthalmological cure in pituitary adenoma].

Fifty-nine pituitary adenomas treated with transsphenoidal approach were analyzed in the light of visual field defects and the postoperative cure rates. Twenty-six cases had visual field defects. The majority of the defects were temporal 1/2 or superior 1/4, although atypical deficits such as incongruous homonymous hemianopsia, nasal 1/2 defect, superior 1/2 defect, peripheral constrict were seen. The visual field defects were correlated with the size of the tumor in Hardy and Vezina classification of the suprasellar extension. The visual field defects appeared in 100% of Type C, 89% of Type B, 50% of Type A, 0% of Type O. In 24 out of 26 patients with preoperative visual field defect, the visual field improved either to normal or wider fields postoperatively. There were 9 patients with optic atrophy, which also showed the correlation with the tumor size. Only the tumor of Type B or C revealed optic atrophy but still 45.4% patients in this group had no optic atrophy. The visual field defect in 85% of the patients without optic atrophy improved to normal post-operatively, while 66% with mild and only 20% with severe optic atrophy showed complete recovery. In conclusions, authors emphasize followings. 1) Improvement rate in the visual field defect of pituitary adenomas by transsphenoidal approach was superior to the previously reported rates by transcranial operations. 2) The factors affecting the functional prognosis in the visual field defect are the natures of the tumor, surgical approach and the factors affecting the plasticity of the optic nerves. The existence and degree of optic atrophy could be one of the references for the plasticity of the optic nerves. 3) There is a close relation between the morphological potential of the tumor and optic atrophy/visual field defect. From these standpoints of view, the early diagnosis and treatment should be emphasized.

Adenoma↗