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S O'Neil

Publications and source records attributed to S O'Neil.

27 records · Page 2Linked to original sources
PubMed1983

Modulation of isocitrate dehydrogenase activity in Acinetobacter calcoaceticus by acetate.

The addition of acetate to a culture of Acinetobacter calcoaceticus grown in medium containing limiting succinate as the sole carbon and energy source leads to an increase in the specific activity of isocitrate dehydrogenase. This is in contrast to similar studies with several other microorganisms in which acetate induces an ATP-dependent phosphorylation and concomitant decrease in the specific activity of this enzyme.

Acetates↗
PubMed1981

Carcinoma of the oesophagus associated with membrano-proliferative glomerulonephritis.

Nephrotic syndrome has been observed in association with different types of neoplasia. This appears to be the first report of the occurrence of the nephrotic syndrome due to membrano proliferative glomerulonephritis in association with carcinoma of the oesophagus. Although proteinuria was present before excision of the tumour, the nephrotic phase occurred subsequently. Eventually it disappeared leaving the patient with a clear urine and biochemical and histological improvement of the renal lesion (including immunofluorescent and electronmicroscopy studies). Possible mechanisms responsible for the nephrotic syndrome in this case are discussed.

Carcinoma, Squamous Cell↗
PubMed1981

Hospice.

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Hospices↗
PubMed1979

High-performance liquid chromatographic analysis of rosoxacin and its N-oxide metabolite in plasma and urine.

A high-pressure liquid chromatographic method for the analysis of rosoxacin and its pyridyl N-oxide metabolite in plasma and urine extracts is described. A statistical evaluation of the assay data has shown acceptable accuracy and precision for 0.5 to 25 microgram of rosoxacin or the metabolite per ml of plasma and for 2.5 to 60 microgram/ml of either compound in urine. The minimum quantifiable level for rosoxacin was 0.13 microgram/ml in plasma and 0.64 microgram/ml in urine; for the metabolite in plasma and urine, the corresponding values were 0.21 and 0.60 microgram/ml, respectively. The method was applied to plasma and urine from three dogs medicated orally with 5 mg/kg of rosoxacin. The pharmacokinetic parameters calculated for rosoxacin were: plasma halflife, 1.9 h; plasma clearance, 65 ml/min; volume of distribution, 11.31. The average total urinary excretion of rosoxacin as free and conjugated rosoxacin and its free N-oxide was 7.7 +/- 0.2% over the 48-h collection period.

4-Quinolones↗
PubMedDate not supplied

Walking the tightrope: balancing health and drug use.

This article stems from a study on San Francisco drug users and their health care experiences. Two hundred thirty-eight study participants were administered depth interviews and questionnaires to reveal a variety of health concerns and health behaviors. For these analyses, which focused on health practices and risky behaviors, the sample was divided into two groups: marijuana users, and other drug users (including methamphetamine, cocaine, heroin, and crack). The findings indicate that drug users behave similarly to the general population regarding health practices, such as eating regularly, sleeping regularly, taking vitamins, and exercising. One finding of interest was the high-risk sexual behaviors of the young, educated marijuana users. A majority of participants demonstrated strong concerns for their health and well-being, and further encouragement on this front is advised. Future research and directions for interventions are recommended.

Adult↗