Postoperative cognitive dysfunction in the elderly.
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Aged↗
Biomedical subjects
S O'Keeffe
Publications and source records attributed to S O'Keeffe.
The prognostic significance of delirium in older hospital patients.
OBJECTIVES: To determine whether delirium is an independent predictor of adverse outcomes of hospitalization in older patients. DESIGN: Cohort study. PATIENTS: A total of 225 people admitted as an emergency to an acute geriatric unit in a university teaching hospital. METHODS: Subjects were screened for delirium, defined by Diagnostic and Statistical Manual, 3rd Edition criteria, every 48 hours. Outcome measures included mortality, duration of hospital stay, hospital-acquired complications, and institutional placement. The influence of delirium on these outcomes was calculated after adjusting for age, illness severity on admission, burden of comorbidity, prior cognitive impairment, and level of disability. RESULTS: Delirium was present on admission in 41 patients (18%) and developed after admission in a further 53 patients (24%). Patients with delirium were more likely than non-delirious patients to have chronic cognitive impairment, severe acute illness, multiple comorbid conditions, and functional disability. Nevertheless, in multivariate analyses adjusting for these factors, delirium was independently associated with prolonged hospital stay, functional decline during hospitalization, increased risk of developing a hospital-acquired complication, and with increased admission to long-term care. CONCLUSION: Delirium is an independent predictor of adverse outcomes in older hospital patients.
Aged↗
Use of restraints and bedrails in a British hospital.
OBJECTIVE: To determine the prevalence of restraint and bedrail use in a British hospital. DESIGN: Cross-sectional observational study. SUBJECTS: Six hundred sixty-eight patients in the acute medical, surgical, and geriatric beds of a large British teaching hospital on a single night. MEASUREMENTS: Observed use of restraints and bedrails. Reasons for restraint use were determined by interviews with nursing staff and examination of the case notes. RESULTS: Fifty-six (8.4%) patients had bedrails raised. No other restraints were in use. Reported indications for bedrail use were: prevention of falls (52 patients), prevention of wandering (1), and patient request (3). In stepwise logistic regression analysis, bedrail use was associated significantly with agitated confusion, age 70 years or more, and stroke, while patients on the acute geriatric wards were significantly less likely to have bedrails raised. CONCLUSIONS: Restraint use is relatively uncommon in Britain. Nevertheless, inappropriate use of bedrails is a reason for concern.
Accidental Falls↗
Prediction of failure to survive following in-hospital cardiopulmonary resuscitation: comparison of two predictive instruments.
The purpose of this study is to compare two clinical predictive rules, the pre-arrest-morbidity (PAM) index and the prognosis-after-resuscitation (PAR) score, which predict failure to survive following in-hospital cardiopulmonary resuscitation (CPR). The study population consisted of 274 consecutive adult patients who underwent CPR at University College Hospital in Galway, Ireland over a 2-year period. The PAM and PAR scores were calculated from the most recent data available for each variable prior to cardiac arrest. Performance of the predictive scores was compared using Student's t-test, Pearson chi-square, Fisher's exact test, and receiver-operating characteristic (ROC) curves where appropriate. The PAM index identified 23 patients with a score > 4, while the PAR score identified 59 patients with a score > 5, none of whom survived. The sensitivity of the PAR score for the prediction of failure to survive was 23.7%, while that of the PAM index was 9.2%; neither index incorrectly identified a patient as a non-survivor who eventually survived. The PAR score also had a greater area under the ROC curve, although this difference was not statistically significant (P = 0.07). In summary, the PAR score performed better than the PAM index in the identification of patients who are unlikely to survive following CPR. Although further confirmation is necessary, it may provide useful prognostic information to physicians and patients involved with decisions about do-not-resuscitate orders.
Adolescent↗
Effect of prolonged nifedipine or captopril therapy on lymphocyte magnesium and potassium levels in hypertension.
The effect of prolonged treatment with calcium channel blockers on potassium and magnesium stores is uncertain. We measured lymphocyte and serum magnesium and potassium in 28 patients treated for hypertension for 6 months with nifedipine or captopril. There was no difference in serum or lymphocyte concentrations in the two groups compared to 45 healthy, normotensive controls. These results suggest that intracellular cation levels are maintained with prolonged therapy with calcium channel blockers.
Adult↗
Do not resuscitate orders in an Irish teaching hospital.
A chart review was performed to determine the resuscitation status of all in-patients in this hospital on a single day. A decision not to resuscitate had been made for 11 (3.7%) of 293 patients. Seven of these patients had a severe stroke, two had dementia and one had a malignancy. We identified a further 22 patients who would be unlikely to benefit from resuscitative efforts but who had not been excluded from resuscitation: four patients with major impairment following a stroke, five patients with severe dementia and 13 patients with incurable malignancy. A policy of routinely discussing and documenting the resuscitation status of patients might reduce the unnecessary performance of cardiopulmonary resuscitation.
Adolescent↗
Effect of captopril therapy on lymphocyte potassium and magnesium concentrations in patients with congestive heart failure.
Lymphocyte potassium and magnesium were measured before and 3 months after the introduction of captopril in 18 patients taking diuretics for congestive heart failure. Compared to 32 healthy controls, 9 patients who had been on potassium supplements plus frusemide had decreased baseline lymphocyte magnesium and potassium concentrations (p less than 0.01), in spite of similar plasma electrolyte levels. There was a significant (p less than 0.01) increase in both lymphocyte potassium and magnesium levels after 3 months' treatment with captopril and frusemide in these patients. Nine patients who had been taking a potassium-sparing combination diuretic also had an increase in lymphocyte magnesium (p less than 0.05) following the introduction of captopril. Increased intracellular potassium and magnesium may be one mechanism whereby angiotensin-converting enzyme inhibitors reduced arrhythmias and improve survival in patients with congestive heart failure.
Adult↗
Age and other determinants of survival after in-hospital cardiopulmonary resuscitation.
A retrospective review of 274 patients who received in-hospital cardiopulmonary resuscitation was performed to determine whether age is independently associated with survival to discharge. Eighty-two (29.9 per cent) of the 274 patients were resuscitated initially, but only 25 (9.1 per cent) were discharged alive. Survival to discharge was significantly poorer in patients aged greater than or equal to 70 years (6/175; 3.4 per cent) than in patients less than 70 years old (19/99; 19.2 per cent) (p less than 0.001). Severity of illness, assessed by the number of diagnoses and a multifactorial morbidity index, did not differ between the two age groups. The best results were obtained with witnessed arrests, ventricular arrhythmias and resuscitation lasting less than 5 minutes; however, elderly patients were less likely to be resuscitated in all circumstances. Age (r = -0.31, p less than 0.001) and the morbidity index (r = -0.18, p less than 0.05) were independently associated with survival by multivariate analysis. These results indicate that advanced age is an important independent determinant of survival after resuscitation. This should be taken into consideration when making in-hospital resuscitation decisions.
Adolescent↗
Comment: potassium supplements vs. potassium-sparing diuretics.
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Diuretics↗
Immunoglobulin G subclasses and spirometry in patients with chronic obstructive pulmonary disease.
Immunoglobulin G (IgG) subclass levels were measured in 58 patients with chronic obstructive pulmonary disease (COPD) and in 125 healthy controls. Total IgG values were significantly lower in the 27 COPD patients on steroid therapy compared with patients not taking steroids (8.31 (0.14) vs 9.80 (0.14), p less than 0.05), geometric mean (log SD). Total IgG (9.80 (0.14) vs 12.18 (0.16), p less than 0.005), IgG1 (5.87 (0.19) vs 6.68 (0.12), p less than 0.05) and IgG2 levels (2.75 (0.21) vs 3.70 (0.20), p less than 0.005) were significantly reduced in the COPD patients not taking steroids compared with the controls. IgG3 values were significantly elevated in smokers compared with nonsmokers in both the control and COPD groups. Fifteen COPD patients (25.9%) had a low level of one or more subclasses. IgG2 subclass deficiency was the most common, being present in 9 patients. A significant correlation was found between forced expiratory volume in one second (FEV1) and IgG2 subclass levels (r = 0.415; p less than 0.005). IgG subclass deficiencies may contribute to the development and progression of respiratory disease in COPD patients.
Adult↗