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Biomedical subjects

S Nundy

Publications and source records attributed to S Nundy.

At least 73 records · Page 4Linked to original sources
PubMed1983

Simultaneous measurement of gastric acid and duodenal alkali secretion by in situ titration in health and disease.

We have devised a technique for simultaneously measuring the acid secretion into the stomach and alkali into the duodenum by in situ titration using a modification of the technique of Fordtran and Walsh. Using this technique, the results of acid and alkali secretion measured simultaneously were identical with those obtained using the conventional aspiration method on separate days. In response to stimulation with pentagastrin acid output was 17.2 +/- 1.4 vs 15.4 +/- 1.9 mmol/h and alkali response with secretin was 16.0 +/- 0.8 vs 14.4 +/- 1.5 mmol/h. The response to food was measured in 10 control subjects, 10 patients with duodenal ulcer, and 10 patients with pancreatitis. In controls, the acid and alkaline secretion were similar (15.8 +/- 1.7 vs 18.2 +/- 1.3 mmol/h), in patients with duodenal ulcer acid secretion was significantly greater than alkaline secretion (31.9 +/- 2.2 vs 21.9 +/- 1.7 mmol/h), and in patients with pancreatitis the alkali secretion was significantly less than acid (19.8 +/- 1.9 mmol/h acid vs 11.4 +/- 0.6 mmol/h alkali). It can, therefore, be concluded that in response to food the patients with duodenal ulcer are significant hypersecretors of acid (DU acid greater than DU alkali output) and patients with pancreatitis are significant hyposecretors of alkali (pancreatitis-alkaline output less than acid output) and normal subjects secrete equal amounts of acid and alkali.

Alkalies↗
PubMed1983

The place of antibiotics in preventing wound infection after clean operations in an Indian hospital: a prospective, randomised, controlled clinical trial.

Two hundred patients in a major Indian hospital who were undergoing clean operations participated in a prospective, randomised, controlled clinical trial of the effectiveness of systemic antibiotics in preventing wound infectious. Of the patients on antibiotics 12.6% developed wound infections and of those not on antibiotics 13.3% did--a difference of no significance. Other factors analysed which included age, duration of operation, place on the operating list and length of the incision did not appear to effect the incidence of infection. Wound infection delayed the discharge of the patient from hospital by seven days. Avoiding antibiotic prophylaxis in these operations would have saved our hospital 12,500 pounds a year. We suggest that prophylactic antibiotics are ineffective in preventing wound infection after clean operations in India. Their use is wasteful and should be discouraged.

Adult↗
PubMed1983

Splenic cyst.

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Adult↗
PubMed1977

Onset of cell proliferation in the shortened gut. Colonic hyperplasia after ileal resection.

Cytokinetics in colonic mucosa were studied after ileal resection in young female rats. The RNA content of the transverse colon was increased 32% after 7 days; after 14 days the increase was present throughout the colon. The DNA content of the ascending colon increased 29% after 10 days. Specific activity of DNA labeled with [3H-methyl]thymidine was elevated 29% in the ascending colon and elevated 49% in the descending colon on the 7th postoperative day. Colonic cell proliferation is stimulated within 1 week of ileal resection.

Animals↗
PubMed1977

Onset of cell proliferation in the shortened gut. Rapid hyperplasia after jejunal resection.

Early manifestations of cell proliferation were studied in the large and small bowel of young female rats after resection of the proximal one-third of the small bowel. On the 2nd day after resection, the absolute amounts of RNA and DNA increased in gut distal to the resection. As compared with values from sham-resected gut, nucleic acid levels in much of the distal small bowel and colon increased. Increased specific activity in DNA after injection of [3H]thymidine was present in the small bowel on the 2nd day. Changes were marked and persistent in midgut for 10 days, tending to be less intense and of shorter duration in segments progressively more distal. Compensatory cell proliferation in midgut occurs within 2 days of jejunectomy.

Animals↗
PubMed1975

The use of neutral red as a peroperative test of vagal innervation.

The cervical vagi were stimulated electrically in four groups of dogs after the intravenous injection of 10 ml of 1% neutral red. One group had intact vagi, the second group had denervation of the distal parietal cell area of the stomach, the third group proximal parietal cell denervation, and the last group had had a complete transthoracic truncal vagotomy. The area of stomach secreting neutral red was significantly related to the insulin-stimulated acid secretion. This technique may provide the basis of a test of residual vagal innervation of parietal cells during vagotomy operations in man.

Animals↗
PubMed1974

Simultaneous combined pancreatic test.

A simultaneous combined pancreatic test can be performed in one morning with only one intubation of the duodenum. The test includes the measurement of exocrine pancreatic secretion of bicarbonate, enzymes, and radioactive selenium, pancreatic scanning, hypotonic duodenography, and cytology of the duodenal aspirate. In the first 70 patients it was found that a single secretion test was of only limited value in detecting pancreatic disease; cytology was the most reliable and scanning the least reliable single test; and that the combined test provided near-complete discrimination between patients with no pancreatic disease, with chronic pancreatitis, and with carcinoma of the pancreas.

Acute Disease↗
PubMed1973

An evaluation of the Hollander test by graded vagotomy in the dog.

Hollander's insulin test was evaluated by performing successively partial denervation of the parietal cell area, highly selective, selective, and truncal vagotomy operations on three dogs. The rise in acidity, the timing of the highest rise in acidity, and the rise in acid output were examined. The mean rise in acidity (m-equiv/l) before vagotomy (106 +/- SE11, 120 +/- 23, 60 +/- 16) did not differ significantly from those obtained after partial denervation (67 +/- SE14, 125 +/- 12, 45 +/- 12). After selective vagotomy, a presumed complete denervation, the rises in acidity were significantly lower (0 +/- 0.1, 2.5 +/- 4, 0 +/- 9). The Hollander test, however, was occasionally negative before any nerves had been divided, and was positive in 20% of tests after presumed complete parietal cell denervation. The highest rise in acidity before vagotomy most commonly occurred 30 minutes after insulin, and following partial denervation this rise occurred significantly later, most commonly at 60 minutes. After the other operations there was no consistent timing. The rise in insulin-stimulated acid output after presumed complete denervation provided near complete discrimination between innervated and denervated stomachs, and its repeatability as assessed by the coefficient of variation was significantly better than the repeatability of rise in acidity. These findings provide support for the contention that the results of the insulin test should be expressed quantitatively in terms of the rise in acid output rather than using Hollander-type criteria of changes in acidity.

Animals↗