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Biomedical subjects

S Nowak

Publications and source records attributed to S Nowak.

At least 73 records · Page 4Linked to original sources
PubMed1986

Peroxide metabolism enzymes in diabetic children: relationship to duration and control of diabetes.

Enzyme activities of erythrocyte superoxide dismutase (SOD), peroxidase and catalase in groups of diabetic children, the duration of the disease and control qualities were compared with respective values obtained for healthy children. Generally the disease duration was clearly found to affect SOD activity, and catalase activity only a little. No similar influence of either diabetes duration or control was noticed in the case of peroxidase. SOD activity was diminished in diabetics when compared with control subjects, and in turn peroxidase and catalase activities were generally elevated. The diminution in SOD activity may constitute a reason for enhanced pancreatic cells susceptibility to deterioration, followed by the augmentation of peroxidase activity with an 'elaborated' mechanism compensating for the loss of erythrocyte SOD activity.

Adolescent↗
PubMed1985

Nonenzymatic protein glycosylation. I. Lowered erythrocyte membrane fluidity in juvenile diabetes.

In order to determine the fluidity of erythrocyte membrane ghosts the degree of random orientation of excited diphenylhexatriene molecules (anisotropy) was examined in normal and diabetic juveniles. A small but significant enhancement of diphenylhexatriene anisotropy was observed in diabetic erythrocyte membranes when compared with control (0.184 +/- 0.013 versus 0.152 +/- 0.010). This alteration was accompanied by an increase of nonenzymatic glycosylation of membrane proteins and haemoglobin in diabetic subjects (25.7 +/- 2.6 versus 21.1 +/- 2.2 and 7.1 +/- 1.4 versus 4.0 +/- 1.0 respectively). Moreover, elevated plasma glycaemia in diabetes was correlated with an increase in membrane anisotropy in the erythrocyte membranes of diabetic juveniles. Linear relationships were seen between glycosylated hemoglobin and glycosylated membrane proteins (r = 0.767) as well as between glycosylated haemoglobin and membrane anisotropy (r = 0.741). We suggest that membrane protein glycosylation enhancement occurring in diabetes could be one of the reasons of the lowered diabetic erythrocyte membrane fluidity.

Adolescent↗