[A case of successful surgical repair for infective endocarditis complicating coronary embolism].
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Biomedical subjects
Publications and source records attributed to S Nishiuchi.
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From April, 1977 to November, 1979, 5 cases with common atrioventricular canal (Rastelli C-type) underwent surgery, in which the leaflets of both the mitral and tricuspid valves were extended using an auto-pericardium patch in order to control regurgitation. Their ages ranged from one year 3 months to 6 years (mean, 3 years 7 months). One case died on the 37th postoperative day from intracranial bleeding unrelated to the cardiac procedure. In the remaining 4 cases, postoperative examination showed an improvement, and their clinical courses which were followed from 2 years 7 months to 5 years 3 months, were favourable, with only minimal valvular regurgitation remaining in all cases. Although the fate of the pericardium patch must be followed over a long period, this procedure appears to be effective for control of regurgitation in this disease.
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Seven patients who were performed thoracotomy for the disease of the chest, were administered cefotiam dihydrochloride 2.0 g for about an hour by intravenous drip infusion during their operation. Antibiotic levels of serum and intrathoracic tissues (a piece of lung parenchyma, parietal pleura, pulmonary hilar lymph node, chest wall muscle, pulmonary cyst and nerve) were determined, and an evaluation of bactericidal effect was discussed. In this study, we found that antibiotic level of poor blood supplied lung, so called the destroyed lung was remarkably high. This means that a high concentration of cefotiam dihydrochloride to intrathoracic tissue is effective against postoperative infection.
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