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Biomedical subjects

S Nishimura

Publications and source records attributed to S Nishimura.

At least 1,009 records · Page 56Linked to original sources
PubMed1975

Distribution of the modified nucleoside Q and its derivatives in animal and plant transfer RNA's.

The modified nucleoside, 7-(4,5-cis-dihydroxy-1-cyclopenten-3-yl-aminomethyl)-7-deazaguanosine, designated as Q, and its derivative, Q*, were found in tRNA's from various organisms, including several mammalian tissues, other animals such as starfish, lingula and hagfish, and wheat germ. Q isolated from rat liver tRNA was found to be identical with E. coli Q by mass spectrometry and thin-layer chromatography. Thus the rare modified nucleoside Q originally isolated from E. coli tRNA, is widely distributed in various organisms. Analysis of the mass spectrum of Q* suggested that it has a different side chain from Q.

Animals↗
PubMed1975

Further studies on cross-immunity among syngeneic tumors in mice.

In the present studies employing 3-methylcholanthrene (MCA)-induced sarcomas of C3H/He mice, cross-immunity among syngeneic tumors was markedly demonstrated by immunization with living tumor cells after repeated inoculation of gamma-irradiated (13, 000 rads 60Co) tumor cells. Cross-immunity was also markedly shown in the challenge of the other MCA-induced tumor, which was induced in the same mouse in which the immunizing MCA-induced tumor originated, by repeated immunization with gamma-irradiated tumor cells only. On the contrary, cross-immunity was not observed between tumors induced on different mice by repeated immunization with gamma-irradiated tumor cells only. As the result of the immunization with gamma-irradiated tumor cells only, common antigenicity among syngeneic tumors seems to be hardly demonstrated, and antigenic indiviDuality among animals, in which MCA-induced sarcomas originated, seems to be remarkably demonstrated.

Animals↗
PubMed1975

Histologic host response to primary methylcholanthrene-induced sarcomas in rats immunized with allogeneic tumors.

Lymphocytic infiltration was observed in 44 of 51 (86%) 3-methylcholanthrene (MCA)-induced sarcomas in rats which had been intensively immunized with allogeneic tumors. Eleven of 29 (38%) tumors with intense lymphocytic infiltration and 5 of 15 (33%) tumors with moderate lymphocytic infiltration were "negative" in autologous transplantation. On the other hand, all of 7 tumors accompanied with slight or no lymphocytic infiltration were "positive".

Animals↗
PubMed1975

Sinus pericranii.

Five cases of sinus pericranii are presented, four congenital and one traumatic. All five cases were successfully treated with extirpation and reinforcement with Gelfoam and silk thread over the skull openings. The literature on this rare symptom-complex is reviewed and a new definition of sinus pericranii proposed.

Adult↗
PubMed1975

Two autopsy cases of diffuse gastrointestinal polyposis with ectodermal changes. Cronkhite-Canada syndrome.

Two autopsy cases of Cronkhite-Canada syndrome were reported. The caused of hypoproteinemia, electrolyte imbalance and ectodermal changes were discussed with reference to previously reported cases. The mechanism of protein loss was probably due to outflow into the intestinal lumen of the mucous substance in the cystically dilated glands, directly and/or indirectly followed by loss of mucosal surface. Electrolyte imbalance probably developed from gastrointestinal loss as well as poor substitution. The ectodermal changes were probably not a subsequent part of the emaciation or hypoproteinemis, but an inherent part of this disease. Therapy, whether substitution or surgical procedure, should be selected in order to control the general condition of the patient.

Adult↗