Biomedical subjects

S Niesert

Publications and source records attributed to S Niesert.

41 records · Page 3Linked to original sources

PubMedDate not supplied

[Acute fatty liver of pregnancy].

Liver diseases in pregnancy can occur as a complication of gestation or independently. Acute fatty liver of pregnancy is a rare disease of unknown etiology specifically associated to gestation. The frequency is increased in the first pregnancy, in the last trimester and in multiple pregnancies. Because of the high maternal and perinatal mortality early diagnosis is necessary for prompt termination of pregnancy. This case report is intended to facilitate the differentiation between acute fatty liver of pregnancy and other liver diseases in pregnancy. The differential diagnoses include preeclampsia, HELLP syndrome, intrahepatic cholestasis of pregnancy and acute viral hepatitis.

Acute Disease↗

PubMedDate not supplied

[Postpartum thyroid gland dysfunction--a prospective study].

In a prospective study the postpartum thyroid function was investigated in 120 healthy women in the department of obstetrics and gynecology of the Medical School Hannover. A physical examination was performed in the first week after delivery and two to five and five to eleven months later. Additionally blood was drawn for the determination of thyroid hormones, thyroid autoantibodies and thyroid-stimulating hormone. In 10% of the patients pathological titers for thyroid microsomal autoantibodies and thyroglobulin autoantibodies were found, in 2.5% pathological concentrations of thyroid hormones. In none of these patients clinical symptoms of thyroid dysfunction could be found. After delivery a immunologically mediated thyroid disease should be considered in patients with clinical symptoms. Then the thyroid function needs to be investigated.

Adolescent↗

PubMedDate not supplied

[Estriol and human placental lactogen as risk indicators in pregnancies of diabetic and hypertensive patients].

The correlation between estriol (E3) and human placenta lactogen (HPL) and perinatal morbidity was investigated in 105 diabetic, 96 hypertensive and 96 pregnancies without diabetes and hypertension. The hormones were determined by radioimmunoassay. Only if two determinations were outside the normal range the values were accepted as pathological. In pregnancies with hypertension a decrease of E3- and HPL-concentrations was correlated to significant higher incidence of operative deliveries and pathological APGAR-Scores. In the diabetic group is the low E3-concentration of significant predictive value in respect of the pathological cardiotocography as the indication of the operative delivery, the same applies to low HPL-concentrations in the hypertension group, in the control group no significant differences could be determined relating thereto. Hypotrophic newborns in the hypertension and control group are significant more frequent, if the concentration of E3 is decreased. The same applies to decreased HPL-concentrations in every group, where the hypertension group shows the highest predictive values.

Adult↗

PubMedDate not supplied

[Influence of non-diabetic pregnancy on fructosamine and HbA1c concentration].

HbAIc and fructosamine concentrations were measured in the course of 177 nondiabetic pregnancies and compared with the corresponding values of 24 nondiabetic nonpregnant women. In all three trimesters HbAIc and fructosamine were significantly lower than the corresponding values in the nonpregnant women; HbAIc: 1st trimester 4.77 +/- 0.62%, 2nd trimester 4.38 +/- 0.59%, 3rd trimester 4.33 +/- 0.49%, p < 0.01; fructosamine 1st trimester 2.13 +/- 0.17 mmol/l, 2nd trimester 2.02 +/- 0.15 mmol/l, 3rd trimester 1.90 +/- 0.15 mmol/l, p < 0.01; nonpregnant women: HbAIc 5.13 +/- 0.41%, fructosamine 2.53 +/- 0.17 mmol/l. However, if the fructosamine is correlated to the respective total protein concentration a constant value results for the course of pregnancy. The changes in the HbAIc and fructosamine concentrations in pregnancy should be taken into account when treating pregnant diabetics.

Adult↗

PubMedDate not supplied

[Wilson disease and pregnancy. Review of the literature and case report].

Wilson's disease is an autosomal recessive disorder of copper metabolism. Since the introduction of penicillamine treatment successful pregnancies have been reported. However little is known about the risks of breast feeding in patients on this medication. We describe the case of a patient suffering from Wilson's disease, who had two uncomplicated pregnancies and breast fed both children for a period of three months each. In the 22 year old gravida I para I the diagnosis of Wilson's disease had been previously made by liver biopsy and penicillamine therapy had been begun. At the time of her first presentation at our department she was 8 week pregnant. Her renal and liver function were normal. Neurologic or psychiatric symptoms were not observed. At 18 weeks the dosage of penicillamine was reduced from 900 mg/d to 750 mg/d. The course of the pregnancy remained uneventful. At 38 + 1 weeks a healthy boy of 3100 gm was delivered. 19 months later the patient presented again in the 16th week of her second pregnancy. Concerning Wilson's disease no major changes were observed, especially liver and renal function were not impaired. The dosage of penicillamin was reduced from 900 mg/d to 750 mg/d during the 21st week. The pregnancy again was uncomplicated and at 38 + 2 weeks resulted in the spontaneous deliver of a healthy boy, weighting 3940 gm. Both children were breast fed over a period of three months and with the exception of an icterus prolongatus no adverse effects were noted.

Adult↗