Search PubMed⌕ Search

Biomedical subjects

S Nicoară

Publications and source records attributed to S Nicoară.

At least 19 recordsLinked to original sources
PubMed2001

[Evaluation of efficacy and safety of sterile solution of lodoxamide in patients with ocular allergy].

PURPOSE: Evaluating the efficiency and safety of Alomide (lodoxamide 01.%) in the treatment of allergic conjunctivitis. MATERIAL, METHOD: 12 patients have been selected during may-august 1998, in order to be treated with Alomide 4 times daily. The clinical exam of the patient included: general information, history, ocular examination. The ocular status of each patient has been evaluated with a score: the intensity of each symptom and sign has been graded between 1-3. RESULTS: In all cases, the use of Alomide induced the improvement of the typical symptoms and signs of the allergic conjunctivitis. No side effect related to the use of the drug has been noted. CONCLUSION: Due to its dual action (inhibition of both mast cells and eosinophils), Alomide covers most of the allergic response.

Administration, Topical↗
PubMed2000

[Ocular changes in dialysis patients].

The study analyzes the ocular aspects in patients receiving hemodialysis, in order to define the importance of the ophthalmological exam as prognosis and follow-up parameter. The prospective study includes 84 patients with renal insufficiency who received hemodialysis between 1994-1998. The ocular aspects and their connection with the dialysis and the basic disease are described and analyzed. The most important were the retinal vascular complications: hypertensive retinopathy, anterior optic ischaemic neuropathy, central retinal artery occlusion, diabetic retinopathy.

Eye Diseases↗
PubMed2000

[The mechanisms of neuronal death in glaucoma].

The current therapy of glaucoma (drugs, LASER, surgery) acts mainly on the trabecular meshwork and on the ciliary body. The loss of the visual function in glaucoma is however determined by the disfunction and death of the ganglion cells. The main theories trying to explain the death of the ganglion cells in glaucoma are analyzed. Their practical value is represented by the finding of the ideal neuroprotective drug.

Animals↗
PubMed2000

[Modern concepts in the pathogenesis and treatment of glaucoma].

The reduction of the visual performances in glaucoma may be explained by several theories. The most admitted theory, for the present, considers glaucoma as a progressive primitive optic neuropathy, having the origin at the retinal ganglion cells, associated with a disease of the sclero-corneal trabeculum, whose porosity is diminishing. The most important pathogenic hypothesis in glaucoma are: the vascular, the mechanical and the collagenic hypothesis. The vascular theory considers that the prolonged ischemia is a responsible for the neuronal alteration. In this process are participating a lot of factors: the intraocular pressure, the blood pressure and some other factors governing the vascular tone of the optic nerve (myogenic factors, metabolic factors, vasoactive factors, circulating hormones and endothelial factors). From therapeutical point of vue, these modern concepts are reflected in the new therapeutic perspectives, with a special attention for the axonal outflow and trabecular cell disfunction and also for the dysregulation of the cellular oxidoreduction.

Endothelium↗
PubMed2000

[The clinical aspects in myopic retinal detachment].

UNLABELLED: Beside aphakia and senility myopia is one of the major factors predisposing to retinal detachment. The purpose of the study is to define the clinical features of the myopic retinal detachment with therapeutic and prognostic implications. METHOD: 100 myopic (< 6 dioptres) retinal detachments that were hospitalized in the Ophthalmological Department from Cluj-Napoca between 1996-99 are retrospectively analyzed. RESULTS, DISCUSSION: The major clinical elements having an impact in defining the anatomical and functional prognosis of the myopic retinal detachment are described and analyzed: the extension of the retinal detachment, the number and shape of the retinal ruptures, the detachment of the macula, the association of aphakia and of myopic choroidosis.

Adult↗
PubMed2000

[Ocular refraction and branch of retinal vein occlusion].

PURPOSE: To evaluate the significance of refractive errors in cases of branch retinal vein occlusion (BRVO). METHODS: We included in this study 179 patients with BRVO who attended our department between 1996-2000. We compared this group with an equal number of age, sex and associated diseases matched controls. The spherical equivalents of the refractive errors of patients in both groups were compared using the chi-square test and Student's t test. RESULTS: Hypermetropia was present in 114 patients wit BRVO (63.68%) and in 82 controls (45.8%, p = 0.00048). Myopia was present in 16 patient with BRVO (8.9%) and in 39 controls (21.8%, p = 0.0037). Emetropia was found in 49 patients (27.37%) and in 58 controls (32.4%, p = 0.299). CONCLUSIONS: Hypermetropia is significantly more common in patients with BRVO than in general population, but myopia is significantly less common in these patients than in controls.

Female↗
PubMed1999

[The diode laser and diabetic maculopathy].

PURPOSE: Revealing the diode laser therapy's results in the diabetic macular edema. METHOD: The diabetic retinopathies in which macular photocoagulation has been performed (between Sept. 1996-Sept. 1998) are analyzed. The cases were selected according the ophthalmoscopy appearance: clinical significant macular edema. The technical features and the clinical and functional parameters' evolution after the treatment are described. RESULTS: Visual acuity's evolution has been stationary in 80% of cases. No complication during or after the macular photocoagulation with the diode laser has occurred.

Diabetic Retinopathy↗
PubMed1998

[The eye and kidney diseases].

The study points out the main conditions in which the ocular lesions are associated with the renal ones. These conditions are grouped as follows: 1. Ocular complications of the renal disorders, hemodialysis and renal transplantation. 2. General disorders with simultaneous ocular and renal lesions. 3. Oculo-renal syndromes.

Eye Diseases↗
PubMed1998

[Obstructions of the retinal artery branches--the clinical and therapeutic aspects].

The purpose of the study is the evaluation of the therapeutical results in arterial retinal branches obstructions, according their etiology and clinical features. The study includes 30 patients with arterial retinal branch obstructions, hospitalized in the Ophthalmological Department from Cluj, between 1989-1996. The temporal branches have been significantly more frequently affected (73.33%), as compared to the nasal ones (6.66%). We noticed no difference in visual acuity's recovery according the precocity of the therapy. Visual acuity's recovery after the arterial retinal branches obstructions is under the simultaneous influence of a group of factors. In this context, the most important ones are: the etiopathogenetic mechanism and the degree of the arterial obstruction. Under these circumstances, an important consideration has to be given to the prophylactic component of the treatment.

Adult↗
PubMed1997

[Vitreous surgery in ocular traumatology].

This study points out vitreous surgery's indications, technical means and results in various ocular traumatisms. Over one-year period, in the Charles Nicole Hospital in Rouen, vitreous surgery has been performed in 67 patients with ocular traumatisms. The surgical techniques, the intra- and postoperative complications are described and correlated to the preoperative ocular status. Results are significantly better in the group with iatrogenic traumatism than in the one with accidental traumatisms. Vitreo-retinal surgery is the only therapeutical method in various ocular traumatisms intraretinal foreign bodies, nonmagnetic intraocular foreign bodies, posttraumatic tractional retinal detachment, giant retinal tears, posttraumatic intravitreal hemorrhage without spontaneous resolution. Without vitreo-retinal surgery, visual function's loss would have occurred.

Adult↗
PubMedDate not supplied

Correlation between left ventricular diastolic function and exercise testing in patients with old myocardial infarction.

There is no correlation between left ventricular (LV) systolic function and effort capacity of the patients with acute or old myocardial infarction (MI). On the other hand, some recent studies suggest such a relationship for LV diastolic function. Twenty-five patients with old MI were submitted to a maximal symptoms limited exercise testing (ET) and to an echo Doppler examination; functional aerobic impairment (FAI), myocardial aerobic impairment (MAI), maximal exercise capacity (METs NYHA class), isovolumic relaxation time (IVRT), E and A wave velocity, E/A rate being calculated. There is a negative significant correlation between MAI and E velocity (r = -0.68), but not between MAI and A velocity or IVRT. The data sustained the correlation between LV diastolic dysfunction and myocardial ischemia, but not with effort capacity of the patients, the last one being determined mainly by other factors. The LV diastolic function indices were modified in anterior but not in inferior MI, in relation with the amount of myocardial necrosis. It is concluded that, like LV systolic function, LV diastolic function does not correlate with the effort capacity of the patients with MI, but it represents a good predictor of the severity of myocardial ischemia mainly in anterior MI.

Diastole↗
PubMedDate not supplied

[Acute lymphoblastic Ph1-positive leukemia with a hybrid phenotype. The significance of the Ph1 anomaly and the hybrid phenotype].

The present paper reports on a case of acute lymphoblastic leukemia with t(9q+; 22q-) and surface markers specific of the B and T lymphoid line (hybrid phenotype). The fundamental (genotypical and phenotypical) and practical aspects (nosologic and therapeutical aspects) of this particular subtype of Ph1-positive acute leukemia and hybrid phenotype are discussed.

Adult↗
PubMedDate not supplied

Ph1-positive polycythemia vera.

The rare presence of the ph1 chromosome in chronic myeloproliferative disorders other than chronic granulocytic leukemia (CGL), i.e. polycythemia vera (PV), myeloid metaplasia with myelofibrosis (MMM) and hemorrhagic thrombocytopenia (HT) raised the question whether or not the Ph1 chromosome is peculiar to CGL. In an attempt to answer this question, the authors reports six cases of positive-Ph1 of which two are from their personal experience and four from the literature. Three of these six cases converted to CGL. The authors conclude that the cases of Ph1-positive PV and HT are transition forms to CGL, and the cases of Ph1-positive MMM are in fact secondary forms derived from CGL.

Adult↗