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Biomedical subjects

S Nevo

Publications and source records attributed to S Nevo.

30 records · Page 2Linked to original sources

Inheritance of PiM subtypes. A study of 151 families with a total of 242 children and of 142 mother-child pairs.

Pi phenotypes were classified by isoelectric focusing in sera of 151 families with a total of 242 children and in sera of 142 mother-child pairs. The six common subtypes of PiM are genetically determined by three alleles named PiM1, PiM2, and PiM3. No exceptions to the postulated mode of inheritance have been found. The possibility of further heterogeneity of the intermediate variant PiM3 is discussed.

Alleles↗

Genetic studies on the Gc subtypes.

Gc subtypes were determined by immunofixation isoelectric focusing. In a family study involving 93 families with a total of 176 children, a three-allele model with six genotypes was confirmed. The distribution of Gc subtypes was studied in three populations from Europe and in a sample of Druzes from Northern Israel. Three new variant Gc types were observed.

Alleles↗

HLA polymorphism in Israel. 9. An overall comparative analysis.

HLA gene frequencies in 11 Israeli populations and nine other relevant populations were used to calculate genetic distances in a quantitative assessment of their similarities and differences. The shortest distance found is between Polish and Rumanian Jews, while the largest is between Russian Jews and Black Africans. Estimates of "average" distances within major population groups suggest that the Ashkenazi Jews (Poles, Russians, Rumanians and Germans) are a more homogeneous population than East European non-Jews or than Middle-Eastern populations (Arabs, Armenians, Lebanese and Turks). A cline of distances between Ashkenazi Jews and other Jewish communities parallels their geographic distribution; however, the relatively large distance between the two North African communities (Libyans and Moroccans) demonstrates that geographic proximity is not necessarily correlated with genetic similarity. The Jewish populations, especially the Ashkenazi, show a clear divergence from their neighboring non-Jewish populations, among whom they have lived for many centuries. There are indications in the HLA data of a common origin for the diverse Jewish populations.

Gene Frequency↗

Familial ovarian carcinoma: a problem in genetic counselling.

Ovarian papillary adenocarcinoma is reported in two families. In one family, this tumor was detected in four females, of whom two had had mammary cancer below the development of the ovarian tumor. In the second family, a mother and daughter died of ovarian adenocarcinoma. The mode of inheritance in both families fits the pattern of autosomal dominant transmission of a single gene. Both are Jewish families from Germany, presently residing in Israel. The two families are presented as examples illustrating the difficult question of genetic counselling in families with recurrent cases of ovarian carcinoma. The difficulty arises because this tumor is relatively frequent but is usually observed in isolated cases without systematic follow-up in the patients' families. Only a few cases, where more than one person in a family is affected, have been selectively reported in the literature.

Adenocarcinoma, Papillary↗

A rare adenosine deaminase allele (ADA6) in an Arab moslem village in Israel.

The rare allele ADA6, was detected in seven members of an Arab Moslem family from northern Israel. All had the electrophoretic pattern of heterozygotes ADA6--1. This phenotype was formerly described in a small German family. The individuals examined in this study are a small branch of a much larger family only part of which lives in Israel. The origin of the family was traced back to a tribe which migrated to Jordan in the XVIII th century from the Kingdom of Hegaz in the northern part of the Arabian peninsula.

Adenosine Deaminase↗

Genetic polymorphism of AHSG, FXIIIB, HP and PLG serum proteins in six Jewish groups in Israel.

The allelic distribution of the polymorphic serum proteins AHSG, PLG, FXIIIB and HP was studied in six Jewish groups who migrated to Israel from the Middle East, North Africa, Rumania, Bulgaria, Central and Eastern Europe. The observed AHSG and PLG allele frequencies in these Jewish groups were more or less similar to the observed distributions in non-Jewish populations from their respective areas of origin, while FXIIIB and HP frequencies were similar to those in European populations. Therefore, no uniform pattern of genetic relationships between the Jewish groups was observed. A genetic distance analysis including comparative data from Europe and the Middle East reflected differences between the Jewish groups according to their areas of origin.

Africa, Northern↗