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Biomedical subjects

S Neill

Publications and source records attributed to S Neill.

27 records · Page 2Linked to original sources

Computed tomography in failed back syndrome.

A significant number of patients complain of recurrent symptoms following lumbar spine surgery. The main differential diagnosis is between post-operative epidural fibrosis and recurrent disc protrusion. Computed tomography is generally preferred to myelography for making this distinction, not least by the patient. Intravenous contrast medium can further improve diagnostic specificity. This article reviews the practical aspects and diagnostic accuracy of computed tomography in failed back syndrome, and draws attention to the potential pitfalls and less common abnormalities which may be encountered.

Cicatrix↗

The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women.

Seventy-eight excised specimens of squamous cell carcinoma of the vulva were reviewed retrospectively for the presence of lichen sclerosus or vulvar intraepithelial neoplasia (VIN) at sites proximal to the tumour or more distant. Lichen sclerosus was evident in 61% and VIN alone in 31%. VIN III (differentiated) was associated with over 50% of the specimens with lichen sclerosus. HPV 16 was found in six of the 11 VIN lesions, investigated but in none of the six with lichen sclerosus.

Adult↗

Vasculitis complicating cystic fibrosis.

Twelve patients with skin vasculitis complicating cystic fibrosis are described. Seven of these were proven histologically and of these two had systemic vascultitis. Staining of vasculitic tissue by the avidin-biotin immunoperoxidase technique using both monoclonal and polyclonal antisera directed against Haemophilus influenzae, staphylococcus aureus and Pseudomonas aeruginosa did not consistently reveal any bacterial antigens in these tissues. In one patient the vasculitis appeared secondary to ranitidine. There was no evidence of autoimmune disease in any of the patients. Antineutrophil cytoplasmic antibodies were detected in the serum of 40 per cent of the patients with vasculitis complicating cystic fibrosis but in none of 61 controls with cystic fibrosis (but without vasculitis) matched for age and sex and with similar bacteriological flora of sputum.

Adult↗

Psychiatric morbidity in women attending a clinic for vulval problems--is there a higher rate in vulvodynia?

A General Health Questionnaire (GHQ) was completed by 55 women attending a clinic for vulval problems in central London. The GHQ-caseness rate was 40% from which the psychiatric morbidity in the sample was estimated to be 32%. The level of psychiatric morbidity in 10 women with a diagnosis of vulvodynia was similar to that of 41 women with other vulval diagnoses.

Adult↗