Search PubMed⌕ Search

Biomedical subjects

S Nawa

Publications and source records attributed to S Nawa.

At least 91 records · Page 5Linked to original sources
PubMed1982

Development and clinical application of a new membrane oxygenator using a microporous polysulfone membrane.

We have developed a new plate-type membrane oxygenator (MO) using a microporous polysulfone membrane. The MO is compact, handy and very easy to set up, and has easy defoaming. The MO is primed with crystalloid; through the cardiotomy reservoir, air exits across the porous membrane and is removed through ports in the membrane oxygenator. Performance and clinical use have shown that the PS oxygenator has a better gas exchange than conventional silicone oxygenators, with appropriate O2/CO2 balance and a capability for controlling oxygen and carbon dioxide separate exchange. The advantage of the MPS membrane is improved blood compatibility, and TABLE 1. BLOOD GAS ANALYSIS DURING PERFUSION Mean +/- SD Range Blood Flow (L/min) 1.56 +/- 0.29 1.04-2.12 Gas Flow (L/min) 1.89 +/- 0.73 0.5-3.0 Gas/Blood Flow Ratio 1.19 +/- 0.38 0.45-1.95 pH venous 7.340 +/- 0.083 7.220-7.443 arterial 7.390 +/- 0.080 7.272-7.507 pCO2 (mm Hg) venous 44.8 +/- 10.8 29.6-65.2 arterial 35.7 +/- 7.1 23.8-51.1 pO2 (mm Hg) venous 46.4 +/- 17.2 26.1-98.8 arterial 276.3 +/- 135.6 66.1-533.4 SO2 (%) venous 71.9 +/- 14.7 35.7-95.6 arterial 98.7 +/- 2.3 91.5-99.9 a larger number of small pores than the MPP membrane. Vapor loss, thought to be typical of microporous membranes, was found to be negligibly small. Use of the PS oxygenator for open heart surgery on 15 pediatric patients proved satisfactory, and in the future the oxygenator may prove useful for prolonged perfusions.

Animals↗
PubMed1976

Total correction of Ebstein's anomaly by replacement with a biological aortic valve without plication of the atrialized ventricle.

For the surgical management of Ebstein's anomaly, the preferred operation will be Hardy's procedure, which preserves the patient's valve. However, we have encountered 3 cases of this disease in which the downward displacement of the tricuspid valve was so severe and the functioning right ventricle was so small that Hardy's method could not be adapted without causing tricuspid regurgitation and making the right ventricular chamber more narrow. We treated these patients by replacing the tricuspid valve with an inverted aortic valve with a stent and not plicating the atrialized ventricle. The results have been proved satisfactory through about 7 years' follow-up, suggesting that our technique will be remarkably effective as a radical corrective operation for Ebstein's anomaly with severe intracardiac abnormalities.

Adolescent↗
PubMedDate not supplied

Three major coronary artery-to-left ventricular shunts: report of three cases and review of literature.

Among the congenital coronary artery fistulas, diffuse fistulation into the left ventricular chamber, usually expressed in terms of a coronary artery-left ventricular shunt, is not as rare today as was previously thought. However, the origin of such a shunt from all three major coronary arteries is rare. This paper reports three cases of such an occurrence and presents the clinical features and management of this rare anomaly by analyzing 31 cases, including 28 from the literature.

Aged↗
PubMedDate not supplied

Congenital coronary artery fistulae arising from bilateral coronary arteries and emptying into both pulmonary artery and left ventricle: a rare presentation.

Congenital coronary artery fistulae rarely empty into both the pulmonary artery and the left ventricle. To our knowledge, there have been only two such cases reported in the literature. This paper presents a third case. The pattern of drainage into the left ventricle in the present case was, however, quite different from that observed in the previous reports.

Adult↗
PubMedDate not supplied

Twenty-four-hour isolated heart preservation by perfusion method with oxygenated solution containing perfluorochemicals and albumin.

In Experiment 1 the donor hearts (group C) perfused for 24 hours with an intracellular-like solution containing perfluorochemicals, calcium antagonist, and albumin were compared with the hearts immersed for 24 hours in an intracellular-like solution to which calcium antagonist was added (group B) and the hearts in which the ischemic time was less than 1 hour (group A) followed by orthotopic heart transplantation. In Experiment 2 perfusates with (group I) and without (group II) perfluorochemicals and albumin were used for 24-hour isolated heart preservation. Periodic assessment of the hearts was performed during the perfusion. Experiment 1: All transplanted hearts started beating spontaneously. There was no statistically significant functional difference between the three groups. At the end of the preservation the creatinine phosphokinase and lactate releases of group C were at lower levels than those in group B. Electron microscopic examination revealed that the myocardium in group B was damaged more severely than in group C. Experiment 2: The level of the creatinine phosphokinase and lactate dehydrogenase released in group I was lower than that in group II. The lactate concentration was at a lower level in group I. At the end of the preservation the pyruvate concentration was higher in group I. The gain in heart weight in group II was more marked than that in group I. The passive compliance decreased only in group II. It is suggested that the perfusion method is superior to the immersion method for 24-hour isolated heart preservation and that the perfusate containing perfluorochemicals and albumin is useful.

Albumins↗