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Biomedical subjects

S Naruse

Publications and source records attributed to S Naruse.

At least 235 records · Page 13Linked to original sources
PubMed1981

Follow-up study of chronic pancreatitis.

The general profile of pain in the evolution of pancreatitis was analysed in relation to exocrine and endocrine pancreatic function in 127 patients with primary chronic pancreatitis followed up over 3 years. Pain decreased or disappeared in 67.8% and 55.9% of calcifying pancreatitis, respectively. While pancreatic exocrine function remained abnormal in spite of an improvement of pain in 72% of 18 patients with calcifying pancreatitis, it improved with the amelioration of pain in 64% of 25 patients with non-calcifying pancreatitis during the follow-up period. Alcohol abstinence seems most important for pain relief in patients with non-calcifying pancreatitis but not calcifying pancreatitis. Changes in glucose tolerance test were not related with those in pain. In calcifying pancreatitis, 69.2% of patients with calcifying pancreatitis were diabetic or became so, while 66.7% of patients with non-calcifying pancreatitis remained non-diabetic during the observation period.

Adult↗
PubMed1981

[Nuclear magnetic resonance studies on brain edema--time course of 1H-NMR relaxation times (author's transl)].

1. The state of water in normal and edematous brain tissue was studied by measurement of proton longitudinal (T1) and transverse (T2) relaxation times using pulsed nuclear magnetic resonance (NMR) technique. 2. In control rats, T1 and T2 of water showed one component, which was more fast in white matter. Those values displayed 1.07-1.18 sec. of T1 and 75-76 msec. of T2. 3. When rat brain was injured by cold, T1 was observed to become more longer (1.18-1.27 sec.), and T2 was observed to be separated into two components, the faster T2 (45-50 msec.) and slower T2 (100-105 msec.), in body gray and white matter of the injured side. 4. In triethyltin (TET) induced brain edema, elongation of T1 (1.2 sec.) and remarkable separation of T2, faster T2 (75 msec.) and slower T2 (400-450 msec.), were observed in white matter. 5. In both cold and TET induced edema, slower T2 fraction is suggested to be the extracellular space and faster T2 fraction, intracellular. 6. T2 changes precede the water content changes in cold injury, and parallel in TET induced edema. Those changes of relaxation times are reversible. 7. T2 changes of water is more sensitive than the T1 for the detection of production and disappearance of brain edema. 8. These results disclose the dynamic movements of water during the course of brain edema and offered significant information of the clinical application of NMR-CT.

Animals↗
PubMed1980

Renal handling of secretin in dogs: free and stop flow analyses.

Renal handling of secretin was studied in anesthetized dogs. Highly purified porcine secretin was infused into the renal artery and its concentration in plasma and urine was measured by a radioimmunoassay. Free flow experiments demonstrated that secretin appeared in urine above 10 ng/ml of plasma secretin and that its urinary excretion was increased in proportion to the plasma level of the hormone. Clearance of secretin was less than 0.05% of creatinine clearance and nearly constant over the plasma range of 10-170 ng/ml. In stop flow studies secretin appeared in urine in the same manner as inulin when both substances were injected simultaneously. This indicates that the hormone is filtered through glomerular capillary membranes. The maximal fall of secretin concentration during an infusion of the hormone appeared around the distal portion of the nephron where the dip of Na concentration was present. This suggest, although not entirely excludes the possibility of proximal reabsorption of secretin, that the hormone is reabsorbed around the distal portion of the nephron. It may be concluded that secretin, once filtered by the glomerulus, is reabsorbed by the tubular epithelium.

Animals↗
PubMed1979

[Medulloblastoma with extracranial metastases--a case report (author's transl)].

A case of medulloblastoma with extracranial metastases was reported. A 20-year-old woman was operated on for cerebellar medulloblastoma twice during the past 5 years and a half. Two years after the second operation, she revealed the metastases to the cervical, axillar and inguinal lymphnodes, and to the skeletal system, such as the skull, scapula, humerus, sternum, spine, pelvis and femur. The cause of extracranial metastases in the very core in this case. While the tumor was located deep in the cerebellar hemisphere at the first operation, it spread over the cerebellar surface at the after the second operation, so that the tumor cells became infiltrative to the dura mater. Thus through lymphatic and circulatory system extracranial metastases occurred. The location of the tumor seems important in this case.

Adult↗
PubMed1978

[Repeated intracerebral hemorrhage in malignant astrocytoma--a case of apoplectic manifestation (author's transl)].

A case of 26-year-old female with malignant astrocytoma was described. Intracerebral hemorrhage appeared in apoplectic fashion on two occasions and surgery was done after each attack. At the first operation, a hematoma in the right putaminal region was totally evacuated and a specimen from the cavity wall showed tumor cells which could not be classified histologically at that time. The patient fully recovered postoperatively. Astrocytoma was confirmed 4 months later by the second operation for the repeated intratumoral hemorrhage. Only a half of the tumor was removed by the third operation. It was apparent that the tumor occupied the site of the right basal ganglia and infiltrated the internal copsule. We discussed the massive intratumoral hemorrhage and propose a craniotomy instead of simple trepanation for the treatment of intracerebral hematoma in order to make adequate biopsy of the hematoma wall and to remove the coexisting tumor, if present.

Adult↗