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Biomedical subjects

S Naraqi

Publications and source records attributed to S Naraqi.

At least 55 records · Page 3Linked to original sources

The role of percutaneous lung aspiration in the bacteriological diagnosis of pneumonia in adults.

In a prospective study of 175 adults with acute pneumonia, percutaneous lung aspiration (PLA) was performed in 144 in an attempt to obtain a bacteriological diagnosis. Positive cultures were obtained from PLA in 90/144 cases (62.5%). The most common organisms isolated were Streptococcus pneumoniae (60%) gram-negative bacilli including Hemophilus influenzae (26%) and Staphylococcus aureus (11%). In 39% of those patients with positive PLA cultures, the same organism was isolated on blood cultures. Complications of PLA were uncommon, with hemoptysis in 4% and chest wall hematoma in 0.7% of patients. The incidence of post-aspirate pneumothorax was not determined in this study. PLA was found to be a safe and effective method of obtaining a bacteriological diagnosis in adult patients with pneumonia.

Adult↗

Haemophilus influenzae pneumonia in Melanesian adults: report of 15 cases.

In a prospective study of 170 adult patients with acute pneumonia, Haemophilus influenzae was found to be the aetiological agent in 15 cases (8.8%). The diagnosis in all cases was based on positive cultures of blood or percutaneous lung aspirate, or both. Chronic lung disease was significantly more common in patients with H influenzae pneumonia than in patients with pneumonia due to other organisms but age, sex, and smoking history did not differ significantly. Lobar consolidation was the most common radiological pattern, being present in 10 of the 15 cases. Type b was the commonest serotype isolated, but three cases were due to non-typable (non-capsulate) strains. All patients survived, responding well to treatment with penicillin, ampicillin, or chloramphenicol. Haemophilus influenzae should be considered as a possible cause of pneumonia in adults, particularly those with underlying chronic lung disease.

Acute Disease↗

Herpes simplex virus and cytomegalovirus infections in burned patients.

Herpesvirus infections are commonly seen in immunosuppressed patients and may account for considerable morbidity and some mortality. We prospectively studied 52 patients with severe burn injuries in order to determine the prevalence of viral infections in this group of patients. Serologic testing was done each week to diagnose primary and reactivation infections. Twenty-seven of 52 patients (52%) became infected with either herpes simplex virus (HSV) or cytomegalovirus (CMV) or both. HSV infection was associated with older age, tracheal intubation, facial burn, inhalation injury, length of hospitalization, and the presence of full-thickness burn. CMV infection was associated with duration of hospitalization and full-thickness burn. Transfusion of blood products was not correlated with an increased incidence of primary or reactivation CMV infections. There was a significant correlation between the presence of these viral infections and bacterial sepsis (p less than 0.05). There was no significant association of HSV or CMV infections with mortality.

Adolescent↗

Disseminated herpes simplex infection with retinitis in a renal allograft recipient.

An immunosuppressed recipient of a renal allograft developed bilateral necrotizing retinitis. Disseminated herpes simplex infection was documented by clinical findings and serologic and viral culture studies. Cultures and serologic tests for cytomegalovirus were negative. The evidence strongly favored the diagnosis of herpes simplex retinitis. Tapering of immunosuppressive drugs and administration of adenine arabinoside appeared to halt temporarily the progression of the disease in one eye and resulted in healing of the retinitis in the other eye. Subsequent progression of the more severely involved right eye resulted in an exudative retinal detachment and loss of vision prior to the patient's death from meningoencephalitis. Herpes simplex retinitis must be considered in the differential diagnosis of necrotizing retinitis in an immunosuppressed patient.

Adult↗

Hematogenous staphylococcal pneumonia secondary to soft tissue infection.

Staphylococcal pneumonia is rare, has a high mortality and morbidity rate, and occurs commonly during influenza epidemics (airborne) or during the course of right sided bacterial endocarditis in drug addicts (blood borne). In recent years, much emphasis has been given to the staphylococcal infections in intravenous drug abusers. This report describes ten patients with staphylococcal pneumonia resulting from soft tissue infection who were previously healthy and had no history of drug abuse. They were 12 to 45 years old. Eight were male patients. Soft tissue infection was community-acquired in nine and was most commonly located in the lower extremities. Three patients had diabetes. All presented with a clinical picture of acute pneumonia. Hemoptysis occurred in three. Chest roentgenogram showed multiple large or small round discrete densities in most of the patients. Lobar involvement was notably absent. Eight developed cavitary lesions in their lungs. The average length of hospital stay was 40 days. One patient died and six developed complications. Staphylococcal etiology should be suspected in patients with acute pneumonia who have soft tissue infection or have characteristic chest roentgenogram findings; antistaphylococcal agents should be included in the therapeutic regimens of such patients until the results of the cultures are known.

Adolescent↗