We examined the antibacterial susceptibility of Staphylococcus aureus isolated from several types of skin infections, which were classified into four groups: (i) impetigo, (ii) folliculitis, (iii) atopic dermatitis and eczema and (iv) ulcers and decubitus. The 50% minimal inhibitory concentration (MIC50) of the antibacterial agents was 3.13 micrograms/ml or lower, except that of gentamicin with isolates from the impetigo groups (25 micrograms/ml). The MIC90 of gentamicin was 50 micrograms/ml or more for isolates from all four groups. The isolates from the ulcers and decubitus group showed multiple resistance against antibacterial agents. The frequency of methicillin-resistant S. aureus was low, but was highest, at 25%, in the isolates from the ulcers and decubitus group. Few isolates from the atopic dermatitis and eczema group were resistant, and there was little difference in antibacterial resistance between isolates from atopic dermatitis and eczema.

Anti-Bacterial Agents↗

PubMedDate not supplied

Sensitivity to antibacterials of Staphylococcus aureus isolated from skin infections: a comparison of two hospitals.

We compared the sensitivities to antibacterials of Staphylococcus aureus strains isolated from skin infections in two hospitals of different sizes. There were differences between the two hospitals in the proportions of the strains isolated that were resistant to certain drugs, and these differences may be related to the patterns of drug use at each hospital. The differences in the patterns of drug use at each hospital may be due to the types of infections encountered and/or the ages of the patients, both of which differed greatly. The proportions of resistant strains may also be related to differences in the proportions of in-patients.

Anti-Bacterial Agents↗

PubMedDate not supplied

Staphylococcus aureus in the anterior nares and subungual spaces of the hands in atopic dermatitis.

We examined the prevalence of Staphylococcus aureus in the anterior nares and the subungual spaces of the hands of patients with atopic dermatitis to determine whether the presence of S. aureus at these sites may contribute to the aggravation of the dermatitic skin lesions. The prevalence of S. aureus in the anterior nares of patients with atopic dermatitis was over five times higher than that in the anterior nares of patients with other skin diseases or in healthy adult controls, and the prevalence of S. aureus in the subungual spaces was 10 times higher in patients with atopic dermatitis than in those with other skin diseases or in controls. Both the anterior nares and the subungual spaces of the hands are important reservoirs of S. aureus in atopic dermatitis. The phage type of S. aureus strains isolated from the anterior nares is similar to that of the strains isolated from the subungual spaces.

Adult↗