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Biomedical subjects

S Nagase

Publications and source records attributed to S Nagase.

At least 235 records · Page 13Linked to original sources
PubMed1978

[Comparative studies on lactate dehydrogenase in serum and plasma of rats (author's transl)].

Values of serum and plasma LDH in rats were comparatively studied, and the following results were obtained: 1) The activity of LDH increased in serum with time during clotting, but no changes of LDH activity were found in plasma. 2) When platelet rich plasma (PRP) was recalcified and allowed to clot, LDH-release from platelets with a corresponding increase of serum LDH was observed, but addition of ADP or thrombin to PRP did not have an effect on LDH-release. 3) LDH-release from platelets by calcium was not inhibited by aspirin, and it was influenced by the quality of the test tube. 4) Values of serum and plasma LDH on experimentally induced liver-damaged or kidney-damaged rats and tumor-bearing rats were examined in relation to their tissue damages, revealing that plasma LDH activity represents the condition of a disease better than serum LDH activity.

Acute Kidney Injury↗
PubMed1978

[A simplified method for determination of biochemical marker genes in inbred strains of mice (author's transl)].

A rapid method is described for the determination of biochemical variants of mice by Titan III cellulose acetate electrophoresis. Variants examined were hemoglobin beta-chain, serum esterase-1, malic enzyme (supernatant form), and isocitrate dehydrogenase (supernatant form). The present procedure can be recommended as a simplified method to analyze biochemical variants for checking of marker genes in inbred strains of mice.

Animals↗
PubMed1975

Mucopolysaccharides of rat ascites hepatoma, AH-100B.

The present study was undertaken to determine the mucopolysaccharide content of cells, AH-100B, and in the ascites, liver, and kidney of a rat bearing this hepatoma. AH-100B is similar to other mixed-type cells in having heparan sulfate as the main component in its mucopolysaccharides but its minor component was different in containing heparin. The main mucopolysaccharide in the ascites of AH-100B bearing rat was hyaluronic acid, which was similar to that of control ascites induced by injection of polypeptone, but minor component contained heparin derived from the cells. The content of hyaluronic acid in the liver of a rat bearing this hepatoma was higher than those of control liver and liver of a rat bearing other tumors. There were no significant differences between control kidney and kidney of a rat bearing this hepatoma.

Animals↗