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Biomedical subjects

S N Teplova

Publications and source records attributed to S N Teplova.

33 records · Page 2Linked to original sources
PubMedDate not supplied

[The effect of the amine salt of 2,4-dichlorophenoxyacetic acid on the cluster- and colony-forming capacity of the bone marrow and on the mononuclear phagocyte system].

In experiments on 124 noninbred white rats weighing 180-200 g the influence of the intragastric administration of amino of 2,4-dichlorophenoxyacetic acid in doses of 2.0 and 20 mg/kg daily on the characteristics of their mononuclear phagocyte system was studied. The study revealed a decrease in the number of monocytic precursors in the marrow, an increase in their capacity for colony formation, the inhibited cell function on the periphery of the system simultaneously with the enhancement of oxidizing processes. The metabolic activation of cells was accompanied by their functional insufficiency, which led to the activation of monocytopoiesis and the increased migration of monocytes to peripheral blood.

2,4-Dichlorophenoxyacetic Acid↗
PubMedDate not supplied

[Characterization of immunological parameters of the lacrimal fluid in patients with various types of the course of keratoconus].

Local immunity is analyzed in 81 patients (146 eyes) aged 16-49 years with three clinical patterns of keratocone. During long remission, IgG level was the maximum. In progressive disease, sIgA and transferrin levels were increased. The most pronounced shifts were detected in the patients with acute keratocone: increased concentrations of IgM, C3 and C4 complement components, alpha 1-antitrypsin, orosomucoid, lysozyme activity, and immune complexes. These data prompt the development of pathogenetically based approaches to the treatment of patients with various clinical immunological types of keratocone.

Acute Disease↗
PubMedDate not supplied

[Etiology and systemic immunity disturbances in patients with tuboperitoneal infertility].

The etiological structure of the inflammatory diseases of genitals at different levels of the reproductive tract of women with tuboperitoneal sterility was studied. The study revealed the prevalence of cocci in the cervical canal, anaerobes in the endometrium and chlamydiae in the abdominal cavity (peritoneal fluid, the ovarian capsule, fimbriated ends), as well as the presence of mixed infection in 27% of the patients under study. The specific features of immunity in women with tuboperitoneal sterility were established, which determined the main trends of the subsequent pathogenetically oriented immunocorrection.

Adult↗
PubMedDate not supplied

[Characteristics of the population and subpopulation composition of peripheral blood lymphocytes in noncomplicated pregnancy based on flow cytofluorometry data].

The population and subpopulation composition of peripheral blood lymphocytes of 33 women was studied in the dynamics of non-complicated pregnancy by the method of flow cytofluorometry with the use of equipment and reagents supplied by Becton Dickinson, Inc. This study revealed that the non-complicated course of pregnancy was characterized by the adequate reaction of the mother's immune system ensuring the physiological development of the fetus during pregnancy and timely labor.

Adult↗
PubMedDate not supplied

[Changes in oxidative processes in the anterior segment of the eye in patients with keratoconus].

Biochemical parameters of the tears, reflecting oxidative processes in the eyes, were analyzed in 79 patients (146 eyes) aged 19-42 years with progressive and acute keratocone and with long remission of the disease. The data indicate disorders in oxidative processes with predominance of aerobic oxidation over anaerobic in the anterior segment of the eye. Evaluation of lipid peroxidation and antioxidant enzymes showed predominance of prooxidant processes over oxidant. These disorders are related in keratocone and differ in progressive, acute condition, and remission. The greatest changes in the lacrimal oxidative processes are observed during the disease progress and even more so in acute disease. The detected changes in the lacrimal biochemistry in patients with keratocone can be regarded as an important mechanism underlying the dystrophic processes in the cornea.

Adult↗
PubMedDate not supplied

[Keratocyte apoptosis in keratoconus].

Analysis of 37 corneal disks removed in perforating keratoplasty for stages II-IV keratocone and of 15 corneal disks (control) from subjects dead from mechanical injuries at the age of 17-35 years was carried out. The expression of CD95 receptors on keratocyte membranes was evaluated by indirect immunofluorescent label using rabbit antibodies. Keratocyte apoptosis was evaluated by indirect immunofluorescent labeling of nuclear DNA nucleotides. Estimation of the volumic share of keratocytes expressing CD95 on cell membrane showed it to be almost 8-fold higher and apoptosis index almost 5-fold higher in the keratocone corneal disks than in the control. The results indicate the presence of a Fas-mediated mechanism of keratocyte apoptosis and its manifold predominance in the cornea in keratocone. These results are clinically significant for the choice of pathogenetic therapy of patients with keratocone.

Adolescent↗
PubMedDate not supplied

[Immunologic peculiarities of uveitis concurrent with systemic pathologies].

Immunologic examinations were performed in 111 patients with uveitis concurrent with a variety of systemic pathologies, including 85 males and 26 females, mean age--32.4 +/- 5.8. A higher IL-6 content in blood serum (BS) and in lachrymal fluid (LF) was detected in all patients. The IL-4 content was lower in uveitis associated with ankylosing spondylitis and with Reuter's disease, whereas, it was higher in juvenile rheumatoid arthritis. The systemic immunity changes were related with the hemostasis impairments in the phagocytic, humoral and cellular chains: an enhanced functional activity of phagocyte cells, a lower absolute quantity of T-lymphocytes, a higher count of B-cells, a reduced concentration of IgM and of circulating immune complexes (CIC), and a diminished general hemolytic activity of the complement in BS. A reduced concentration of the secretory fraction of IgA, IgG and IgM concurrent with higher concentrations of IgA, C3- and C4 complement components, CIC and of lysozyme activity in LF was detected in the local immunity system.

Adult↗
PubMedDate not supplied

[Results of the microbiological, clinical and immunological examination of children with Reiter's disease].

Infectious agents were detected in 100% of examined children with Reiter's disease (RD). Chlamydia trachomatis were detected in 98% of cases. In children with RD lesions of joints and eyes often took acute forms with cases of sacroiliitis, early muscular atrophy and conjunctivitis. In 95% of the patients the prostatitis manifestations were detected. In children with RD a rised number of CD lymphocytes in combination with the fivefold rised IL-4 content, an essential increase in the activity of C2-C5 components of the complement and a multiple rised level of PSA were registered.

Adolescent↗
PubMedDate not supplied

[The immunity of patients with keratoconus].

Cellular and humoral immunity parameters were studied in patients with keratoconus at different stages, aged 14 to 49 years. The results showed the immune homeostasis to be impaired in patients with local involvement of the cornea. At a total system's level the patients developed shifts in the relative content of T-lymphocytes and their subpopulations, dysimmunoglubulinemia with increased levels of immunoglobulins of the primary immune response in the blood serum, high levels of the C3 and C4 components with a reduction of the total hemolytic activity of the complement, increased levels of NBT-positive and phagocytic cells, and a decrease of the activity of serum lysozyme.

Adolescent↗
PubMedDate not supplied

[Clinical immunological classification of tuberculous uveitis].

Clinical and immunological studies carried out in 251 patients with tuberculous uveitis (TU) revealed three types of inflammatory reactions in the uveal tract in this patient population: productive, exudative, and productive-exudative (mixed), differing by the type of immune disorders. The findings helped develop a clinical immunological classification of TU, taking account of the clinical form of uveitis, type of inflammatory reaction of the uveal tract, disease pattern, involvement of one or both eyes, complications, and the immunopathological variants of TU course.

Adolescent↗
PubMedDate not supplied

[Systemic and local immunity in patients with diabetic retinopathy].

Total-systems and local immunity parameters were assessed in the lacrimal fluid of 118 patients with nonproliferative and proliferative diabetic retinopathy (DR). Humoral and cellular immunity characteristics of the total-systems immunity were shifted and local immune homeostasis impaired. The most manifest changes were detected in patients with proliferative DR. The authors hypothesize a possible contribution of local immune disorders to the pathogenesis of DR.

Adolescent↗
PubMedDate not supplied

[Results of immunogenetic typing of lymphocytes of patients with keratoconus].

Histotyping of HLA I antigens in 100 patients with keratoconus. Europeoids of the Chelyabinsk district, and of 701 controls (donors listed in the regional register) showed an increased incidence of HLA A28, B12, and B15, a decreased incidence of HLA B8, B13, and complete absence of HLA A11. Estimation of HLA haplotypes in keratoconus showed an increased incidence of haplotypes A1-B5 (relative risk RR = 5.9), A2-B15 (RR = 3.34), A2-B27 (RR = 2.12), and A9-B21 (RR = 4.13) and decreased incidence of A1-B8 (RR = 0.31). The incidence of incomplete phenotypes was 27%. The most incident of incomplete phenotypes was A3-B35. Reliably linked HLA haplotypes A3-B7, A2-B27, A9-B21, and A9-B35 were typical of men with keratoconus, whereas A2-B21 haplotype was characteristic of the female patients.

Adult↗
PubMedDate not supplied

[State of local immunity in keratoconus].

Local immunity was studied in 81 patients (146 eyes) aged 11-49 with keratoconus at different stages of the disease running different course. The concentrations of IgG, IgM, secretory IgA, lysozyme, immune complexes, C3 component of the complement, transferrin, and alpha 1-antitrypsin are increased in tears of patients with keratoconus, reflecting the activation of local immunity in this condition.

Adolescent↗