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Biomedical subjects

S N Sullivan

Publications and source records attributed to S N Sullivan.

At least 55 records · Page 3Linked to original sources
PubMed1982

Inhibition of basal and stimulated gastric acid secretion by an enkephalin analogue.

The effect of a synthetic enkephalin analogue (Sandoz FF33-824: DAMME) on basal and submaximally stimulated gastric acid secretion was investigated in six healthy hypersecretors. Basal acid secretion was markedly inhibited by the enkephalin analogue. When gastric secretion was stimulated by a continuous intravenous infusion of 100 ng/kg/h of pentagastrin the enkephalin analogue reduced acid output by 50%. Intravenous naloxone reversed the subjective effects of the enkephalin analogue but did not reverse the inhibitory effect on basal and stimulated acid secretion.

Adult↗
PubMed1982

The effects of naloxone and morphine on postprandial gastrointestinal hormone secretion.

Postprandial gastrointestinal hormone secretion was not affected by the intravenous administration of naloxone. However, after the administration of morphine, multiple effects were observed. Postprandial pancreatic polypeptide, motilin, and enteroglucagon secretion were abolished and there was a reduction in the secretion of insulin, gastric inhibitory polypeptide, and neurotensin. There was prolonged secretion of gastrin. Levels of vasoactive intestinal polypeptide, somatostatin, and pancreatic glucagon were not affected. Many of these changes can be accounted for by the ability of morphine to delay gastric emptying. The prolonged secretion of gastrin could result from a combination of impaired gastric emptying and reduced postprandial gastric acid secretion. Inhibition of vagal acetylcholine release is the most likely explanation for the abolition of pancreatic polypeptide secretion. With the exception of the effects on motilin, pancreatic polypeptide, and enteroglucagon secretion this study provides no evidence that opiate substances directly affect the secretion of gastrointestinal hormones.

Adult↗
PubMed1981

The gut hormone profile of fulminant hepatic failure.

Twenty-five patients with fulminant hepatic failure and grade III or IV hepatic encephalopathy were studied. Plasma insulin, glucagon, pancreatic polypeptide and enteroglucagon were significantly raised. Levels of secretin and gastrin were normal, while motilin concentrations were significantly depressed. Vasoactive intestinal polypeptide was increased in six patients and was significantly higher in those patients who were hypotensive or who had marked prolongation of prothrombin time.

Acute Kidney Injury↗
PubMed1980

Blue rubber bleb nevus syndrome.

A 26-year-old man presented with chronic iron deficiency anemia. The presence of cutaneous lesions typical of the blue rubber bleb nevus syndrome led to the radiologic and endoscopic documentation of gastrointestinal hemangiomas. This is the first Canadian case report of this rare syndrome. A review of the 26 cases reported to date illustrates the difficulties involved in management. For the present, conservative treatment is recommended.

Adult↗