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Biomedical subjects

S N Smith

Publications and source records attributed to S N Smith.

31 records · Page 2Linked to original sources
PubMed1989

Effect of iron depletion on cell-wall antigens of Candida albicans.

Cell walls were isolated from stationary-phase cultures of Candida albicans grown at 25 degrees C or 37 degrees C, in iron-depleted and iron-sufficient conditions. Proteins solubilised from cell-wall fractions were separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Approximately 40 protein bands were detected by Coomassie blue staining in all wall extracts, regardless of temperature or other growth condition. Sera from patients with oral or systemic candidosis, from whom the isolates were obtained, and pooled normal human serum were examined for the presence of IgG and IgM antibodies to cell-wall proteins by Western blotting. Patient sera recognised more antigens than pooled normal human serum. In particular, an antigen of 44 kda was detected by IgG antibodies in the sera of patients and two antigens of 41 and 14 kda were detected by their IgM antibodies when the sera were used as probes against walls from iron-depleted cells, but not from iron-sufficient cells, grown at 25 degrees C. Two antigens of 45 and 40 kda were detected by IgM antibodies in the sera of patients tested against walls from iron-depleted but not from iron-sufficient cells grown at 37 degrees C. IgG antibodies did not distinguish between these wall preparations from cells grown at 37 degrees C. These results suggest that the specific cell-wall proteins induced during growth in iron-depleted conditions, as well as other proteins, were immunogenic and were recognised by the patients' antibodies.

Antibodies, Fungal↗
PubMed1987

Work expectations and organizational attachment of hospital pharmacists.

Measures of expectations, organizational attachment, and job satisfaction were studied among hospital pharmacists. Pharmacists in 42 Chicago-area hospitals were asked to respond to 18 closed-ended statements designed to measure job and profession satisfaction and the degree to which the respondents' expectations of their work and profession had been met. From the sample of 529 pharmacists, 217 (41%) usable responses were received. Pharmacists generally agreed that their expectations toward work, salary, department standards, and use of professional abilities had been met. However, it was found that younger pharmacists and those performing primarily staff duties had lower ratings for met expectations and satisfaction than did their counterparts. Measures of expectations and satisfaction with current jobs consistently outranked similar measures of opinions toward the profession. Organizational attachment appeared to be highly correlated with age and with tenure of employment; younger pharmacists and those with one to seven years of concurrent employment were more predisposed to leaving the organization. It was noted in particular that the factors exerting a strong influence to leave the organization involved management-related activities and responsibilities. Managers can encourage organizational attachment by providing promotion opportunities and leadership in the structure and facilitation of job duties and by responding to individual needs.

Age Factors↗
PubMed1986

Factors influencing the rate of job turnover among hospital pharmacists.

Factors influencing the rate of job turnover among hospital pharmacists were studied. In June 1982, pharmacists and pharmacy directors in acute-care hospitals in the Chicago area with more than 100 beds were asked both open-ended and multiple-choice questions pertaining to reasons for accepting and staying at current jobs, reasons for leaving previous and possibly current jobs, career goals, and demographic data. From the sample of 529 pharmacists, 217 (41%) usable responses were received. Pharmacy directors' responses indicated that the turnover rate for pharmacists was 14.4% and that relocation and layoffs or job termination were the most common reasons for job turnover. Overall, pharmacists' pay and benefits and opportunity for promotion or advancement were the reasons pharmacists cited most frequently both for leaving a job and for staying at a job. Men ranked pay and benefits as the most important reason for taking and staying at a position and for leaving, whereas women cited hospital location as the most important reason for taking, staying at, or leaving a job. Other factors cited as important were working hours, professional challenge, job duties, and continuation of education. Pharmacists who had been in the current job for more than two years were less likely to leave. Pregnancy of the employee or spouse was not a strong reason for leaving, and relocation was a more important reason for women than for men. Approximately half the respondents indicated they had a career goal; promotion to management and continuation of education were the goals most frequently mentioned. Regional or national studies should be conducted to gain further understanding of why pharmacists accept, remain in, and change jobs.

Chicago↗
PubMed1983

Organization and administration of hospice care.

In these days of ever increasing health care costs, hospice is an important health care delivery method for insuring individualized, humane care of the terminally ill at a reasonable cost. In this article the authors discuss hospice concepts and strategies essential for the successful development of a hospice care program. Practical suggestions are provided for helping you develop a hospice program.

Hospices↗
PubMed1978

Calcifying odontogenic cyst with ameloblastic fibro-odontome: one lesion or two?

The calcifying odontogenic cyst is unusual in that it is frequently found in conjunction with the histologic features of a variety of other odontogenic conditions. Two cases are reported, one of which contained areas histologically similar to the ameloblastic fibro-odontome and also showed condensations of cells in the stroma beneath epithelial strands proliferating from the cyst lining. In both cases the "ghost cells" stained strongly for disulphide groups but only occasional areas were positive for sulphydryl groups. No amyloid or "amyloid-like" material was detected. As no part of the current name is specific to this lesion it is suggested that the nomenclature should be changed--perhaps to "ghost cell dyst".

Adult↗
PubMed1977

Restricted mandibular movement. Report of 2 unusual causes.

Hypomobility of the temporomandibular joint has a variety of causes. Two patients are presented in whom restricted jaw movement was the only clinical manifestation of serious underlying disease. The importance of submitting all tissues removed from patients for histopathological diagnosis is stressed.

Adult↗