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Biomedical subjects

S N Sinha

Publications and source records attributed to S N Sinha.

At least 37 records · Page 2Linked to original sources
PubMed1993

Early childhood mortality--a rural study.

The present study was conducted in 9 villages of Rural Health Training Centre, Jawan, Aligarh, India, having 1792 registered families. The infant mortality rate was 79.3 per 1000 live births. Higher mortality in children between 1-2 years (29.6/1000) in comparison to 2-5 years (16.2/1000) reflected the higher vulnerability of children below 2 years. Diarrhoea (21.2%) and neonatal factors (21.2%) were the major cause of infant mortality followed by pneumonia (18.2%) and tetanus (15.1%). Diarrhoea (32.2%), pneumonia (22.6%) and malnutrition (12.9%) were the major killers in children between 1-5 years. Mortality in females was higher than males in infancy. Risk factors associated with infant mortality included extremes of maternal age (< 20+ > 35 years) primipara or multipara and illiterate mothers.

Cause of Death↗
PubMed1993

Intramural haematoma of the duodenum.

Intramural duodenal haematoma secondary to blunt abdominal trauma is a rare injury. One case is reported, and the clinical features, diagnosis and management are discussed.

Abdominal Injuries↗
PubMed1993

Deliberate self-harm by means of kerosene fire by women in Papua New Guinea.

This paper reports the results of an investigation into the psychosocial and sociodemographic factors relating to 10 females admitted to the Burns Unit of the Port Moresby General Hospital with a common diagnosis of deliberate self-inflicted burns by kerosene fire. All 10 patients were admitted during the first six months of 1990 and all originated from Gulf Province. 6 of the 10 patients died despite intensive, standard surgical management. Discussion of the results centres around the possible causes of the sudden increase in the number of patients presenting with burns caused by self-inflicted kerosene fire. Recommendations are made for some preventive measures.

Adolescent↗
PubMed1991

Clinicopathological features of primary gastrointestinal lymphomas: a study of 42 cases.

The clinicopathological features of 42 patients with gastrointestinal lymphoma during the period 1982-88 are described. Ten cases (23.8%) were seen in the stomach, 23 cases (54.8%) in the small intestine and 9 cases (21.4%) in the large intestine. In 4 cases multiple sites were involved. The tumours occurred most frequently in the 2nd to 4th decade. Histologically, using the working formulation for non-Hodgkin's lymphoma, all were found to be diffuse and mostly of the high grade type (45%). Seven lymphomas were seen in children. Three were of the Burkitt's type. Patients presented quite late in a large number of cases (43%). Compared with most other published series small intestinal involvement was common. There was a high incidence in males. Predominant small intestinal involvement did not result in malabsorption syndrome and primary lymphomas constituted 3.5% of all malignancies of the gastrointestinal tract.

Adolescent↗
PubMed1990

Trauma patients in an Indian hospital.

The study was carried out at the Emergency Department of Jawaharlal Nehru Medical College Hospital, Aligarh Muslim University, Aligarh, India, to ascertain the pattern of trauma in the patients. A total of 2446 trauma cases were recorded in the year 1987. Accidental falls were the commonest cause of injury, i.e 35.7%, followed by motor-vehicle collisions (23.5%), pedal cyclists (8%), occupational injuries (5.2%) and sports injuries (5.2%). The commonest age group involved was 5-15 years which accounted for 32.8% of all trauma. Fractures (44%) were the most frequently observed nature of injury. Death due to trauma was highest in motor-vehicle collisions (31%) followed by accidental falls (16%), and occupational injuries (12%).

Adolescent↗
PubMed1990

Anthropometric measurements in rural school children.

Anthropometric measurements of 1012 rural school-going children, selected randomly, were performed. There were 776 males and 236 females in the age group of 5-15 years. The values of weight and height were recorded for every child in the study sample. Age and sex break-up was studied and compared with the ICMR (Indian Council of Medical Research) standard. The comparison made separately for boys and girls showed that the values for both sexes and in all age groups were less than the ICMR standard. The majority (83.6%) of the children belonged to the middle and low social class according to the modified Prasad's classification. An inference is, therefore, drawn that rural school children of middle and low socio-economic status are shorter and lighter as compared with even their own counterparts on whom the ICMR values are based. The state of health of school-going children in India is far from satisfactory despite the fact that school health programmes along with other nutritional programmes have been in operation for several decades. School-going children constitute a sizeable section of India's population, i.e. about 27%, which is easily accessible and also receptive. An early and convenient method of assessing nutritional and socio-economic status of growing children is anthropometry. Physical growth, in terms of weight and height, is considered an important parameter reflecting the pattern of growth and development in a community. In the developing countries, the growing children by and large are deprived of good nutrition on account of their poor socio-economic status, ignorance and lack of health promotional facilities. This nutritional deprivation results in relative stunting of growth.

Adolescent↗
PubMed1989

Road traffic accident fatalities in Port Moresby: a ten-year survey.

A retrospective analysis for a 10-year period (1976-1985) of Road Traffic Accident (RTA) fatalities was carried out in Port Moresby, the capital of Papua New Guinea. The majority of the victims were males and under the age of 45. Passengers formed the largest number, followed by pedestrians and drivers. Most fatal accidents occurred during the weekend. Analysis of injuries reveal head injury to be the dominant and possible cause of death in all three categories of victims. Multiple injuries involving many organs were more common in pedestrians and passengers than drivers. Factors contributing to the high rate of RTAs are discussed and measures to minimise the rate of such accidents have been suggested.

Accidents, Traffic↗
PubMed1989

Responses of small intrapulmonary arteries to vasoactive compounds in the fetal and neonatal lamb: norepinephrine, epinephrine, serotonin, and potassium chloride.

Despite considerable study, the mechanisms responsible for the transition of the pulmonary circulation from the fetal to newborn life remain obscure. We compared the responses of third and fourth generation pulmonary arteries to norepinephrine, epinephrine, serotonin, and KCl from lambs 7 d preterm and 1, 7, and 21 d of age to assess differences between age and third and fourth generations of the pulmonary arterial tree during the transitional period. Preterm vessels were significantly smaller in internal diameter than all other aged vessels for both generations. Fourth generation vessel response to KCl increased with age (94 +/- 15 mg/mm2, preterm; 259 +/- 31 mg/mm2, 21 d). Third generation vessel response to KCl did not change with age (135 +/- 15 mg/mm2, preterm; 158 +/- 18 mg/mm2, 21 d). There were no differences in maximum response to norepinephrine and epinephrine between ages; however, third generation vessel response to these compounds was significantly greater (30-60% of maximum KCl response) than fourth generation vessel response (0-10%). Third and fourth generation vessels had the same maximum response to serotonin regardless of age or generation. Third generation vessels were significantly reduced in sensitivity (log molar concentration which produced 50% of the maximum response--EC50) to norepinephrine at d 1 (5.89 +/- 0.12 log molar) and 7 (5.90 +/- 0.21) compared to preterm (6.48 +/- 0.10) and 21 d of age (6.50 +/- .03).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1986

Illness with fatalities in premature infants: association with an intravenous vitamin E preparation, E-Ferol.

Three clusters of an unusual syndrome in premature infants were investigated in three intensive care nurseries in 1984. A retrospective cohort study of 68 infants weighing less than or equal to 1,250 g at birth and surviving at least 72 hours revealed that in 13 infants ascites developed and in four at least two of the following abnormal laboratory values were found within a seven-day period: serum direct bilirubin greater than or equal to 2 mg/dL, blood urea nitrogen greater than or equal to 40 mg/dL or serum creatinine greater than or equal to 2 mg/dL, and platelet count less than or equal to 60,000/microL. All cases occurred after the introduction and use of intravenous E-Ferol, a vitamin E preparation that was new on the market when the clusters were reported. All 17 case infants but only 23 of 51 (45%) noncase infants received E-Ferol (P less than .0001). Case and noncase infants were similar with respect to other complications and to receipt of medications and parenteral nutrition. A dose-response relationship was found; cases occurred in infants receiving E-Ferol dosages of greater than 20 U/kg/d. Case infants who had higher daily doses of E-Ferol had a shorter latency. No new cases were reported after use of E-Ferol was stopped. Results of these investigations led to a nationwide recall of intravenous E-Ferol.

Adult↗