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Biomedical subjects

S N Sharma

Publications and source records attributed to S N Sharma.

At least 109 records · Page 6Linked to original sources
PubMed1984

Antigenic relationships among sheep pox, goat pox and contagious pustular dermatitis viruses.

Antigenic relationships among sheep pox, goat pox and contagious pustular dermatitis (CPD) viruses were determined by serological techniques using soluble antigens partially purified by DEAE-cellulose chromatography. Homologous antigen-antibody reactions were characterized by the presence of 7 precipitation lines with sheep pox and of 5 ones each with goat pox and CPD viruses. The nature of cross-reactions of sheep pox, goat pox and CPD virus soluble antigens with corresponding sera suggested that sheep pox virus shared 3 soluble antigenic components with goat pox and either 3 or 4 ones with CPD virus. Goat pox virus shared either 2 or 3 soluble antigenic components with CPD virus. Cross-neutralization tests revealed an one-way cross of goat pox virus with sheep pox and CPD viruses, respectively. The results showed that the 3 viruses in question share common soluble antigenic components.

Antigens, Viral↗
PubMed1983

Hyperuricaemia induced by ethambutol.

Seventy patients with pulmonary tuberculosis and 12 healthy controls were included in a study to observe the effect of ethambutol on serum uric acid level. In ethambutol-treated cases a statistically significant increase in mean serum uric acid levels was observed in the second, third and fourth week of treatment. This increase was independent of dosage of ethambutol. However, 22 of the 52 (42%) ethambutol-treated cases showed no increase. Streptomycin was found not to potentiate the hyperuricaemic action of ethambutol. Hyperuricaemia due to ethambutol was reversed with probenicid but not by salicylates. No patient developed acute gouty arthritis although two developed arthralgia.

Adolescent↗
PubMed1982

Vaccination with CDF-66 strain of newcastle disease virus.

Newcastle disease vaccine CDF-66 has been proved effective by the drinking water route. A chicken dose of 10(6.2) EID50 in 12 ml of water containing 2.5% skimmed milk was found to be effective. This produced sufficient GMHI antibody response (105) and 86.6% of birds withstood challenge with the Mukteswar strain of virulent virus. The in-contact birds did not show either immune or antibody response. The vaccinated birds excreted vaccine virus only from the respiratory tract not from cloaca. The vaccine given in drinking water protected only 50% of chickens when it was given 168 h prior to challenge virus. With lesser intervals the protection was negligible. Diluted vaccine when held for 2 h at 37 degrees C and room temperature did not show a drop in potency.

Animals↗
PubMed1982

The pathology of Cysticercus tenuicollis infection in goats.

The pathology of Cysticercus tenuicollis in goats was studied on Days 7, 15, 30 and 60 post-infection. The characteristic gross lesions on the 15th day of infection included accumulation of a large quantity of serofibrinous fluid in the peritoneal and thoracic cavities and a large number of small-sized cysts floating in the fluid of the peritoneal cavity. Large circular brown to red areas with alternate areas of haemorrhages also appeared on the liver surface and in the parenchyma due to migrating C. tenuicollis. The microscopic lesions in the liver included cyst-like channels with a mass of fibrin and erythrocytes. Hepatic cells were mostly degenerated with focal areas of parenchymal destruction. Sinusoids were dilated and the bile ducts revealed degenerative changes. Lungs of animals killed on Day 15, revealed focal areas of emphysema and haemorrhages with lodged larvae of C. tenuicollis. Pleura appeared oedematous. Alveoli showed the presence of serous exudate.

Animals↗
PubMed1981

Acid-base status and blood gas alterations following experimental uremia in cattle.

Experimental uremia created by obstructing the urethra of 7 cross-bred bulls was associated with significant (P less than 0.05) increases in PCV, blood urea nitrogen concentration, arterial and venous pH and PCO2, arterial bicarbonate, and base excess. Total serum protein concentration decreased nonsignificantly. Arterial PO2 reduced significantly during later stages of uremia. Arterial and venous oxygen saturation, arteriovenous oxygen difference, oxygen extraction ratio, and arteriovenous pH difference were not affected significantly. Uremia was characterized by progressive metabolic alkalosis with, as a compensation, hypercapnia, and arterial hypoxemia. There was no evidence of systemic shunting of blood except in 1 animal.

Acid-Base Imbalance↗