[Correction of respiratory and pulmonary circulatory disorders in diabetes mellitus patients by hyperbaric oxygenation and insulin therapy].
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Biomedical subjects
Publications and source records attributed to S N Efuni.
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It has been shown in experiments on dogs that following blood replacement with a plasma substitute up to 0.5-2.5 g/100 ml Hb at an oxygen pressure of 3 at. abs., the morphological changes seen in the cerebral hemispheres, heart, liver, kidneys and lungs assume an adaptation character and are rapidly reversible. Microcirculatory disorders were found to play the leading part in the genesis of cellular changes recorded. The blood analysis data revealed the relationship between the degree of hemodilution and microvascular permeability and overall shifts in energy formation. To reduce the functional tension in the organ tissue systems, it is advisable to exercise the correction of the plasma substitute composition by which the permeability of the histohematic barrier could be stabilized. The hemodilution technique may be applied under hyperbaric oxygenation both in surgery and other fields of medicine with on object of replacing donor's blood by hemodynamic plasma substitutes.
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Sound exposure to 100--120 dB caused death of about 6--16% of white rats KM line from the blood circulation disturbances. The hyperbaric oxygenation (2 atm) decreased the death rate among rats of 4 to 15 months old while having no effect upon younger ones (2--4 months old). The rats who died in hyperbaric oxygenation suffered from O2 intoxication more often than those who survived. Administration of caffeine reduced the positive effect of hyperbaric oxygenation.
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Chronic interrupted effect of hyperbaric oxygenation applied for 4 weeks reduces the rate of the development of myocardial hypertrophy in rabbits and is thus conducive to stabilization of myocardial contractile function on a sufficiently high level and increases the reliability of the circulation system in emergency situations. In the dangerous stage of compensatory cardiac hyperfunctions, hyperbaric oxygenation protects the myocardium from destructive changes and activates bionergetic processes, whereas in the stage of marked hypertrophy it inhibits the development of cardiosclerosis. Hyperbaric oxygenation prevents the development of functional isolation of the hypertrophied myocardium from the neurohormonal effects and contributes to the preservation of the reserve capacity of the neuroeffector mechanisms of heart regulations.
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The results of electro- and polycardiograms characteristis of overloading of the right parts of the heart were studied in 50 patients with diabetes mellitus. Dilatation of the right chambers of the heart was revealed, which the authors think may be mainly due to functional or organic changes in the vessels of pulmonary circulation and is associated with tissue hypoxia. The patients were given the commonly accepted therapy in a complex with hyperbaric oxygenation. Diabetes mellitus became compensated and a tendency towards regression of the earlier revealed changes was noted.