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Biomedical subjects

S N Chatterjee

Publications and source records attributed to S N Chatterjee.

At least 91 records · Page 5Linked to original sources
PubMed1980

National study on natural history of renal allografts in sickle cell disease or trait.

The natural history of renal allograft in recipients who have sickle cell disease or trait has not been widely studied. This survey attempted to collect all the case histories known at present and to assess the relationship of sickle cell disease or trait to the natural history of renal allograft. A questionnaire was sent to 120 transplant centers in North America. 106 centers responded to the study, compliance rate being 88%. 88 centers reported not having any experience with such a case, whereas 18 centers transplanted 34 kidneys in 30 patients with this disease or trait. 9 of these had sickle cell disease and 21 had the trait. Graft survival at 1 year was 23 of 34, i.e., 67%. Mortality was 4 of 30, i.e., 13% in the first year. Sickle cell crisis was noted in 8 patients during the first year, 7 of whom had sickle cell disease. Thus, sickle cell crisis is very common in sickle cell transplant patients. From the points of view of patient survival and graft survival, recipients of kidneys who have the disease or the trait do just as well after transplant as the remaining patient population.

Adolescent↗
PubMed1980

The polymyxin sensitivity and the phosphatidyl ethanolamine content of the Vibrio cholerae membranes.

The phospholipid composition of three different strains of Vibrio cholerae was determined by quantitative two-dimensional thin-layer chromatography. The polymyxin sensitivity of the whole organisms or of the liposomes derived from the total phospholipids of these organisms depended solely on the phosphatidyl ethanolamine content of the system concerned and could be quantitatively related by the equations Y1 = 1.074 X1 - 9.828 and Y2 = 1.22 X2 - 34.47 where Y represents the maximum lysis (%)/hr and X, the % phosphatidyl ethanolamine content of the system concerned, the suffix 1 and 2 corresponding to the liposomal and the whole organisms respectively. The analysis revealed the requirement of a threshold amount of phosphatidyl ethanolamine for the expression of polymyxin action on the system concerned.

Liposomes↗
PubMed1979

Use of vascular prosthesis in the anastomosis of allograft renal artery.

A case is reported in which a cadaveric renal allograft was placed successfully in a patient with a bilateral aortofemoral prosthesis for extensive vascular disease. Convalescence was uneventful and the subsequent clinical course seems to justify fully this operative approach.

Arteriosclerosis↗
PubMed1979

Prospective study of the prevalence and symptomatology of cytomegalovirus infection in renal transplant recipients.

To determine the incidence and symptomatology of cytomegalovirus (CMV) infection in renal transplant recipients, we followed 40 patients prospectively for 5 to 24 months after operation. As judged by the serological change and virus isolation from blood and/or urine, the infection rate for the entire group was 82% (33 of 40 patients). Two types of infection were recognized: primary infection that occurred in 3 patients, and reactivation infection that occurred in 30 patients. Twenty-one patients were asymptomatic and 12 were mildly symptomatic. Four had mild hepatic dysfunction; two had the CMV mononucleosis syndrome associated with mild to moderate deterioration of renal function. Two patients had hyperglycemia. One patient who reached a CMV antibody titer of 1:32,768 was totally asymptomatic other than fever of short duration. CMV-induced pneumonitis or retinitis was not noted, and there was no mortality from CMV infection in our patients. Factors which may be associated with the absence of severe manifestations of active CMV infection in these patients are discussed.

Adult↗
PubMed1978

Primary cytomegalovirus and opportunistic infections. Incidence in renal transplant recipients.

Thirty-five renal allograft recipients were studied concerning the relationship between cytomegalovirus (CMV), herpes simplex virus (HSV), and opportunistic bacterial and fungal infections. The incidence of opportunistic infections was determined for patients whose tests prior to transplantation were seronegative in complement fixation and indirect hemagglutination assays of CMV antibody and for those patients whose tests were seropositive. Among the six seronegative patients with seronegative tests, four (66%) experienced active CMV infection within two months, and four died of Candida or Aspergillus infection within six months after transplantation. Among the 22 patients with seropositive tests, only one (4%) had a fungal infection and it was nonfatal (P less than .05). The increased morbidity and mortality due to fungal and bacterial infections in transplant recipients with seronegative CMV tests appears, therefore, to be related to primary CMV infection rather than to generalized immunodeficiency.

Antibodies, Viral↗
PubMed1978

Sickle cell trait: possible contributory cause of renal allograft failure.

A black male with known sickle cell trait (hemoglobin AS) received two cadaveric renal transplants in succession. After excellent initial graft function he had what appeared clinically to be an acute rejection episode which could not be reversed by immunosuppressive therapy on either occasion. The histopathology of the removed allografts did not reveal a picture of acute rejection, but instead revealed extensive intravascular sickling of the erythrocytes. This is important especially for the transplant centers in the United States which may have a significant number of the black population among the renal allograft recipients.

Adult↗