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Biomedical subjects

S Murata

Publications and source records attributed to S Murata.

At least 343 records · Page 19Linked to original sources
PubMed1975

Mitomycin C bladder instillation therapy for bladder tumors.

Patients with bladder tumors underwent a course of topical bladder instillation of 20 mg. mitomycin C in 20 ml. sterilized distilled water 3 times weekly for a total of 20 procedures. In 22 of the 50 patients (44 per cent) the tumors disappeared completely, while in 16 patients (32 per cent) there was partial disappearance and in 12 patients (24 per cent) there was no affect. Therefore, the total effective rate was 76 per cent. We concluded from our studies that mitomycin C topical therapy could be applied to low stage and low grade bladder tumors less than 1 cm. in diameter, without regard to the number of tumors. We now use mitomycin C topical therapy in all cases of bladder tumors. Local bladder reaction was noted in 3 cases but a complete course of therapy was accomplished in each case--in 2 cases without interruption of treatment and in 1 case by delaying treatment for 1 week. Abnormal values of hematocrit, white blood cells and platelets in blood were not observed during therapy.

Administration, Topical↗
PubMed1975

Effects of diltiazem (CRD-401) on developed coronary collaterals in the dog.

The effect of diltiazem (CRD-401) on coronary collaterals was studied in the dog. The anterior descending branch of the left coronary artery was occluded for 4 to 6 weeks by an ameroid constrictor. In these dogs, the retrograde flow (RF) from the peripheral coronary artery and peripheral coronary pressure (PCP) were significantly higher than those in acute coronary-ligated dogs, suggesting the development of large supraepicardial intercoronary anastomoses. Diltiazem (100 mug/kg i.v.) increased circumflex blood flow (CBF) for several min, while nitroglycerin (10 mug/kg i.v.) increased CBF transiently after which CBF decreased to below control values. Diltiazem (100 mug/kg) and nitroglycerin (10 mug/kg) increased RF/MAP (mean aortic pressure) and PCP/MAP and these increases lasted longer than that of CBF. Diltiazem also increased RF in doses of 100 mug/kg or 20 mug/kg/min. Therefore, diltiazem possesses the property of dilating coronary collaterals thus causing redistribution of intramyocardial blood flow. In acute preparations, however, both diltiazem and nitroglycerin showed no significant changes in PCP/MAP and RF/MAP.

Animals↗