Search PubMed⌕ Search

Biomedical subjects

S Mudd

Publications and source records attributed to S Mudd.

At least 37 records · Page 2Linked to original sources
PubMed1970

Cell Wall Component Which Affects the Ability of Serum to Promote Phagocytosis and Killing of Staphylococcus aureus.

The role of various cell wall components of nonencapsulated Staphylococcus aureus in phagocytosis and killing was studied. Adsorption of human serum with S. aureus cell walls, or trypsin-digested cell walls, reduced the rate of phagocytosis and killing of S. aureus by human-blood leukocytes when compared to unadsorbed serum. When the various components of the cell walls were used for adsorption, only the intact mucopeptide was found to remove these factors. Products of digestion of this mucopeptide with several enzymes were found to be inactive when used for adsorption of human serum. Other components tested were teichoic acids alpha, beta, and combinations of both and protein A. When used in equivalent amounts, these were found to have no effect on the removal of serum factors necessary for phagocytosis and intracellular killing of S. aureus.

Journal Article↗
PubMed1970

Immunologically Induced and Elicited Local Resistance to Staphylococcus aureus.

Allergy characterized by delayed hypersensitivity was induced in populations of mice by injection, respectively, of Staphylococcus aureus and of tubercle bacilli. Eliciting doses of staphylococcal antigen or of old tuberculin antigen were injected subcutaneously into the nape of the neck of samples of these mice. A challenge dose of S. aureus was injected into the site of the eliciting injection, and the subsequent survival curves of the infecting staphylococci were determined by plate counts. Survival of the challenge staphylococci was significantly reduced only when the eliciting antigen was homologous with the inducing antigen. Thus induction and elicitation were specific, but the local resistance was nonspecifically effective against staphylococci.

Journal Article↗
PubMed1967

Electron microscopy of the combination of antibodies with flagellar antigen and with a pyocine.

Micrographs are presented of antibodies in combination with flagella of Salmonella typhi and with a phage-bound pyocine Rmc, which is supposed to be the tail of a defective bacteriophage from Pseudomonas aeruginosa. The pyocine preparation seems to offer advantages for the study of antibody-antigen complexes. Under the conditions of our experiments, the surfaces of the antigenic structures are saturated with antibody layers approximately 95 A in thickness, i.e., slightly less than half the accepted lengths of 7S antibody molecules. Our interpretation is that the antibody is attached by combining sites at the ends of the molecules to form loops along the surface of the antigenic structures.

Animals↗
PubMed1966

Role of serum in the intracellular killing of staphylococci in rabbit monocytes.

Shayegani, Mehdi G. (U.S. Veterans Administration Hospital, Philadelphia, Pa.), and Stuart Mudd. Role of serum in the intracellular killing of staphylococci in rabbit monocytes. J. Bacteriol. 91:1393-1398. 1966.-Although some intracellular killing occurs in rabbit monocytes with heated normal serum or even in monocytes washed three times with Hanks' solution and with staphylococci not exposed to serum, efficient killing of coagulase-positive Staphylococcus aureus cells in the mononuclear phagocytes of rabbits is shown to require heat-labile components of serum. The effect of serum in promoting phagocytosis and intracellular killing may be exhibited either by presensitization of the staphylococcal cells before contact with leukocytes or by the presence of serum in the phagocytic system. Under any conditions studied the rate of intracellular killing of S. aureus is very slow.

Animals↗