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Biomedical subjects

S Morimoto

Publications and source records attributed to S Morimoto.

At least 847 records · Page 47Linked to original sources
PubMed1979

Comparison of human calcitonin secretion after a 1-minute calcium infusion in young normal and in elderly subjects.

Human calcitonin (hCT) response to a 1-minute calcium infusion was studied in 6 male and 4 female young normal subjects and in 6 male and 6 female elderly subjects. In the young subjects plasma hCT levels increased significantly (p less than 0.01) from mean basal value of 82.3 +/- 48.7 pg/ml to maximum level of 407.5 +/-198.0 pg/ml in the male, while it increased from 96.3 +/- 89.2 to 216.3 +/- 89.1 pg/ml p less than 0.05) in the female. In the elderly subjects, it increased from 80.3 +/- 56.9 pg/ml to maximum level of 229.2 +/- 130.6 pg/ml (p less than 0.05) in the male, while it increased from 109.2 +/- 43.7 to 163.3 +/- 55.7 pg/ml (p less than 0.005) in the female. There was no significant difference in the basal hCT level of these 4 groups. In both the young and the elderly, however, mean increment of hCT level was significantly (p less than 0.05) higher in the male than in the female of the same-aged group. In both the female and the male subjects, it was significantly (p less than 0.05) higher in the young than in the elderly of the same sex. A 1-minute infusion of calcium can be used as a reliable provocative test for hCT secretion in human subjects.

Adult↗
PubMed1979

Prolonged pseudoaldosteronism induced by glycyrrhizin.

We describe the natural recovery from the aggravated hypertension, hypokalemia and suppression of the renin-aldosterone axis after the glycyrrhizin discontinuation in two mild hypertensive women aged 71 and 68 years, who had been administered 273 to 546 mg glycyrrhizin daily for 1.5 and 6 months, respectively, for the treatment of liver disease. About one month after the glycyrrhizin discontinuation, acceleration of hypertension, hypokalemia and suppression of the renin-aldosterone system still continued in both patients. At this stage, sodium restriction resulted in the normalization of blood pressure with weight loss and the subsequent sodium repletion produced a rapid increase in blood pressure to hypertensive levels observed before sodium restriction, with weight gain. Plasma renin activity and plasma aldosterone were low and did not respond to sodium restriction. Inappropriately excessive amounts of potassium were also excreted in the presence of hypokalemia. About one and a half months later, the improvements of aggravated hypertension, hypokalemia and suppressed renin-aldosterone system gradually occurred in both patients. Sodium restriction performed about three months later in case 2 no longer produced the changes in blood pressure and body weight. Plasma renin activity and plasma aldosterone responded subnormally to sodium restriction. These results demonstrate that both patients had a prolongation of the syndrome resembling primary aldosteronism except the low plasma aldosterone level about one month after the glycyrrhizin discontinuation. The possible mechanisms by which this prolongation was caused are discussed.

Aged↗
PubMed1979

Self-association of purine base, 6-methylpurine, in water - organic component mixtures.

Thermodynamic quantities of the self-association of 6-methylpurine in water (1)-dimethylsulfoxide (DMSO) (2) mole fraction, x2 less than 0.1) and water (1) - N,N-dimethylformamide (DMF) (2) (x2 less than or equal to 1.0) mixed solvents have been obtained through heat of dilution measurements, at 25 degrees C. In the water-DMSO solvent system, the standard enthalpy and entropy changes, delta Ho and delta So, of the association exhibited an abrupt behavior. They decreased remarkbly with the the mole fraction of DMSO until about x2 = 0.012 and after that, they increased steeply. In the case of water-DMF solvent system, the values of delta Ho and delta So didn't show the abrupt behavior. They decreased steeply until about x2 = 0.1 and, at higher mole fractions, became relatively constant. These behaviors are rationalized on the basis of solvent structural effects and solvation in these association systems.

Chemistry, Organic↗
PubMed1978

[Plasma renin activity response to isometric handgrip exercise in normotensive and hypertensive patients (author's transl)].

1) Plasma renin activity (PRA) response to isometric exercise was studied before and after the intravenous administration of 0.2 mg/kg of propranolol in 8 normotensive and 10 normal renin hypertensive patients. 2) Handgrip exercise at the 30% level of maximal voluntary contraction (MVC) for four minutes induced a significant increase in PRA in either normotensive or normal renin hypertensive patients, while the increase in PRA in normal renin hypertensive patients was significantly higher than that in normotensive patients. 3) Pretreatment with the administration of propranolol inhibited an increase in PRA after handgrip exercise in either normotensive or normal renin hypertensive patients. 4) The results suggest that isometric handgrip exercise can induce an augmentation in renin release mainly by stimulation of the sympathetic nervous system in either normotensive or normal renin hypertensive patients. The possible mechanism of the exaggerated response in PRA to handgrip exercise in normal renin hypertensive patients has been discussed.

Adolescent↗