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Biomedical subjects

S Moore

Publications and source records attributed to S Moore.

At least 469 records · Page 26Linked to original sources
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Antioxidant activity of saliva and periodontal disease.

The antioxidant activity of saliva has been investigated in 28 apparently healthy individuals and seven dental patients with periodontal disease. The results show that the major aqueous antioxidant component of whole saliva is uric acid, with lesser contributions from ascorbic acid and albumin. All are present at lower concentrations than those found in the plasma water. The total antioxidant activity (TAA) of saliva correlates (r2 = 0.972) with the concentration of uric acid, which contributes more than 70% of the TAA. Stimulation of salivary flow is associated with increased production of antioxidants. The antioxidant potential of saliva does not appear to be compromised in patients with periodontal disease but this may relate to the antioxidant flow from the gingival crevicular fluid.

Adult↗
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In vitro interactions between low density lipoprotein from hyperapobetalipoproteinemic plasma and arterial wall proteoglycans.

OBJECTIVE: To examine the interactions of low density lipoprotein-B (LDL-B) with proteoglycans (PG) in vitro. DESIGN: The PG were isolated from human aortas, removed at autopsy by a combination of extraction with 4M guanidine-Tris buffer containing protease inhibitors and fractionation on a DEAE-Sephacel ion-exchange chromatography column. LDL and LDL-B from healthy or hyperapobetalipoproteinemic sera, respectively, were isolated by standard density flotation techniques followed by radioiodination. Radiolabelled lipoproteins (LP) were incubated with proteoglycans at 4 or 37 degrees C in a low ionic strength buffer with or without addition of polyethylene glycol (PEG) which was used to enhance precipitation of the resulting LP-PG complexes. MAIN RESULTS: Data revealed that a specific ratio of LP to PG is a prerequisite for optimal interactions between these macromolecules. Further, it was observed that LDL-B forms fewer precipitable complexes than normal LDL at 4 degrees C. However, at physiological temperature or with the addition of PEG, precipitation of the two LDLs was equal. CONCLUSION: LDL and LDL-B showed equal reactivity with PG in terms of precipitable complexes.

Aorta↗
PubMedDate not supplied

When discrimination supersedes confidentiality.

Recent decisions have made it clear that the courts are now less inclined to apply the doctrine of academic abstention in cases regarding discrimination in promotion and tenure. Colleges and universities with closed rank and tenure proceedings can now expect to be challenged by unsuccessful candidates suspecting discrimination.

Confidentiality↗
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MR imaging of acute experimental ischemia in cats.

The evolution of acute cerebral ischemia was documented by magnetic resonance (MR) imaging in 13 mongrel cats with occlusion of the middle cerebral artery through a transorbital approach. The animals were imaged under anesthesia at intervals from 30 min to 10 days after production of the lesion. An MR imager operating at 0.35 T was used with multislice, multi-spin-echo technique (TR = 500-2000 msec; TE = 28, 56 msec). The animals were sacrificed after imaging for pathologic correlation. Infarcts beyond 4 hr of age were visualized in all subjects. The earliest infarct was seen at 30 min (two cats) as an area of high signal intensity on T2-weighted images. In three other cats, however, 3-hr-old infarcts were not detectable. In one animal, a hemorrhage within a 1-week-old area of infarction was not characterized by MR imaging but was identified on CT scanning. The mass effect of the infarction appeared greatest at 2-4 days after infarction. The basal ganglia showed ischemic effects to best advantage. MR imaging offers previously unavailable sensitivity for the early noninvasive detection of cerebral ischemia in vivo.

Animals↗
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Night shift.

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Humans↗
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Stepping stones.

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Aged↗
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A wellness program model for family practice residency programs.

For some time health promotion and disease prevention have been expected tenets of medical practices with the public. However, the medical profession has only recently emphasized prevention and wellness promotion as required curricula for study at the undergraduate and graduate levels. Family physicians have been at the forefront in accepting this additional responsibility, but actual implementation of such practices has been difficult for the individual physician. To address this needed transitional step from public demand to practice, a wellness program for residents, faculty, staff, and patients was designed for the Family Practice Residency Program at Cheyenne.

Family Practice↗
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Machiavellianism and radiographer job satisfaction.

This article reports the results of a survey conducted to determine the relationship between Machiavellianism and job satisfaction among radiographers. As predicted by the literature, the survey showed a negative correlation between these two constructs-radiographers with higher Machiavellianism had lower job satisfaction, while those with the lowest Machiavellianism had the highest job satisfaction. Education, gender, marital status, race, position and time in position had no significant effect on the two constructs.

Adult↗
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[Considerations on the nursing discipline while approaching the year 2000].

A discipline is characterized by a unique perspective, a distinct way of viewing all phenomena, which ultimately defines the limits and nature of its inquiry (Donaldson & Crowley 1978). Further, Chinn & Jacobs (1987) define discipline as a branch of instruction; a body of knowledge and of systematizing that knowledge within an area of concern or domain of inquiry. The position taken in this paper is that nursing, as it approaches the year 2000, is an evolving discipline that is dedicated to the advancement of knowledge which contributes to the pursuit of excellence of care (AARN 1985). The writer agrees with Jennings' (1987) position that theory gives definition to nursing's body of knowledge, and direction to research and practice. This paper addresses some of the issues and concerns related to the development of nursing knowledge which serve as a cornerstone for the discipline. It goes on to consider briefly a few tasks that face nursing as it approaches the year 2000.

Forecasting↗
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Progress in the development of a transcutaneously powered axial flow blood pump ventricular assist system.

Development of the Jarvik 2000 intraventricular assist system for long-term support is ongoing. The system integrates the Jarvik 2000 axial flow blood pump with a microprocessor based automatic motor controller to provide response to physiologic demands. Nine devices have been evaluated in vivo (six completed, three ongoing) with durations in excess of 26 weeks. Instrumented experiments include implanted transit-time ultrasonic flow probes and dual micromanometer LV/AoP catheters. Treadmill exercise and heart pacing studies are performed to evaluate control system response to increased heart rates. Pharmacologically induced cardiac dysfunction studies are performed in awake and anesthetized calves to demonstrate control response to simulated heart failure conditions. No deleterious effects or events were encountered during any physiologic studies. No hematologic, renal, hepatic, or pulmonary complications have been encountered in any study. Plasma free hemoglobin levels of 7.0 +/- 5.1 mg/dl demonstrate no device related hemolysis throughout the duration of all studies. Pathologic analysis at explant showed no evidence of thromboembolic events. All pump surfaces were free of thrombus except for a minimal ring of fibrin, (approximately 1 mm) on the inflow bearing. Future developments for permanent implantation will include implanted physiologic control systems, implanted batteries, and transcutaneous energy and data transmission systems.

Animals↗