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Biomedical subjects

S Mjøen

Publications and source records attributed to S Mjøen.

6 recordsLinked to original sources

Respiratory tract viruses in otosclerotic lesions. An immunohistochemical study.

A series of viral antigens, including adenovirus, influenza A and B, parainfluenza types 1 and 3, measles, mumps, respiratory syncytial (RSV) and Epstein Barr (EBV) viruses was studied in a prospective series of stapes specimens from 24 consecutive patients operated on for otosclerosis. The stapes specimens were processed for light microscopy and immunohistochemistry. With the exception of one case of positive specific reactivity for anti-RSV antibody in one multinuclear osteoclastic cell, no specific reactivity was seen in the specimens. This was the case both in active (n = 8) and inactive (n = 16) otosclerotic lesions. The possibility of unspecific staining reactions is discussed.

Adolescent

Tuberculous otomastoiditis.

A review of the 20th century English-language literature has produced a total of 320 cases of tuberculous otitis media or otomastoiditis, of which a surprising 93 cases have been reported in the 5-year period 1986-1990. Eighty-three percent of these have come from indigenous African populations. The international health and sociological implications of this development are disturbing. three personal cases seen during the past 8 years are presented, all of whom came from the indigenous Norwegian population. The epidemiology of these cases is therefore different, which can result in a diagnostic delay due to a low index of suspicion. The historically classical signs of this disease are frequently absent.

Adult

Usher syndrome in four Norwegian counties.

Among 89 probands selected for tapeto-retinal degeneration, 18 (20%) were given the diagnosis of Usher syndrome. Among the relatives of the probands another 10 cases of Usher syndrome were found. The distribution on type diagnoses was: Usher syndrome type I: 14 cases, type II: 10 cases and type III: four cases. The pattern of inheritance was autosomal recessive for 12 families, and the remaining six probands were solitary cases without consanguinity between the parents. There was a high intrafamiliar correlation with respect to hearing function, indicating genetic heterogeneity in Usher syndrome. Obligate heterozygotes did not demonstrate heterozygote manifestation. One man with Usher syndrome type I was psychotic, the remaining 27 did not demonstrate serious psychic disturbances. Atactic gait was not observed, though vestibular response was abolished in three patients with Usher syndrome type I. Three patients with type II and one person with type III had normal vestibular response. The prognosis for visual function was not highly correlated to the type diagnosis or to the age when hemeralopia was first noticed. Visual function was good before 30 years of age and bad in most patients after the age of 50.

Adolescent

Effect of human fibrin adhesive on the ear. An electrophysiological study of auditory function in the guinea pig correlated to light and electron microscopy of middle ear mucosa and inner ear structures.

The effect of human fibrin adhesive applied to the middle ear has been studied in guinea pig. Auditory function was measured using acoustically evoked brainstem responses. Middle and inner ear structures were studied with light, transmission and scanning electron microscopy. A transitory conductive hearing loss was observed, but after 8 weeks the auditory function appeared normal. Microscopy of the middle and inner ear failed to show any tissue damage.

Animals