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Biomedical subjects

S Mizuno

Publications and source records attributed to S Mizuno.

At least 469 records · Page 26Linked to original sources
PubMed1987

Localization of hepatitis B core antigens in chronic active hepatitis using immunoperoxidase and chromotrope aniline blue staining.

Hepatitis B (HB) core particle, in biopsied liver specimens from patients with chronic active hepatitis (type B) were stained with immunoperoxidase and chromotrope aniline blue (a non-immunological method) and the following results were obtained. HB core particles were more clearly stained with chromotrope aniline blue than with immunoperoxidase. Numerous HB core particles were seen not only in the nuclei of hepatocytes but also in the cytoplasm in HBeAg seropositive patients with severe chronic active hepatitis. DNAase digestion indicated that the HB core particles which stained with immunoperoxidase and chromotrope aniline blue contained DNA. Small amounts of HB core particles were seen in both the nuclei and cytoplasm of all anti-HBe seropositive patients with either moderate or severe chronic active hepatitis.

Adolescent↗
PubMed1987

[A case report of multiple endocrine neoplasia type 2b].

A 10-year-old girl was admitted displaying a medullary thyroid carcinoma, accompanying neurinomas of the tongue, marfanoid habitus, megacolon, and scoliosis. Although her adrenal glands were found to be unremarkable on both CT and ultrasonogram examination an MIBG scintiscan showed a 131-1 uptake, suggesting the presence of medullary hyperplasia. Remarkable nodal involvement with invasive features witnessed in the upper mediastinum during tertiary surgery four years later, following a total thyroidectomy. The TCT and CEA profiling was not sufficient enough to predict a recurrence. At the present state there is difficulty in providing an early diagnosis; through node dissection, however, is considered to be necessary at time of primary thyroid operation in cases with MEN type 2b.

Carcinoma↗
PubMed1987

The long-term prognosis of patients gastrectomized for benign gastroduodenal diseases.

To study the long-term prognosis after gastrectomy, a total of 6,662 gastrectomized patients who had been operated on for benign gastroduodenal diseases between 1965 and 1980 were followed up from September 1, 1984 to May 30, 1986. The final vital status for the observed period could not be confirmed in 493 patients (7.4%), giving a follow-up rate of 92.6%. The average observation period was 13.1 years. The mortality from total deaths was almost identical to that of the general population adjusted for sex, age, and time trends of mortality, except for lower mortality among males in the first five years after operation. The risk of cancer mortality at all sites was lower than that of the general population, mainly due to the lower mortality from stomach cancer. This trend was not affected either by the type of gastroduodenal disease or by the method of operation. However, lung cancer mortality among males was significantly higher and one of the reasons for that could be excess smoking by males.

Alcohol Drinking↗
PubMed1987

The effects of prostaglandin E1 on the pepsin activities in gastric mucosa and juice.

Prostaglandin E1 elevated pepsin activity in gastric mucosa but lowered pepsin activity in the gastric juice of rats treated by pylorus ligation and intragastric administration of hydrochloric acid. In these animals zymogen granules with low electron density were numerous in the gastric chief cells following prostaglandin E1 treatment. The prostaglandin E1-induced increase in mucosal pepsin activity was slightly inhibited by actinomycin D and there was no apparent increase in 3H-thymidine incorporation into gastric mucosa following treatment with prostaglandin E1. It is suggested that prostaglandin E1 causes an elevation of pepsin activity in the gastric mucosa by stimulating pepsin synthesis and perhaps also by facilitating pepsin release from zymogen granules. However, it also appears to inhibit pepsin release from the mucosa into the gastric cavity judging by the decrease of pepsin activity in gastric juice. The reduced pepsin activity in gastric juice may account, in part, for the reported anti-ulcerative action of prostaglandin.

Animals↗
PubMed1987

[Electrocardiographic and angiographic follow-up of patients with hypertrophic cardiomyopathy].

Electrocardiographic follow-up was conducted for 17 patients with hypertrophic cardiomyopathy including six cases who received left ventriculographic follow-up. 1. Serial ECG changes were as follows: 1) In seven patients negativity of the T wave appeared or increased concomitantly with increased voltage of SV1 + RV5 (A-1 group). 2) In four patients, negativity of the T wave decreased or disappeared with the decreased voltage of SV1 + RV5 (A-2 group). 3) In six patients, there were insignificant changes of both T wave and SV1 + RV5 (B group). 2. Results of serial left ventriculography and biventriculography were as follows: 1) Two patients (A-1 group) showed an increased voltage of SV1 + RV5 (25 mm----48 mm, 42 mm----54 mm), and increased thickness of the apical wall (10 mm----12 mm, 8 mm----11 mm) and the anterior wall (13 mm----16 mm, 10 mm----16 mm). However, the thickness of the posterior and interventricular septal walls did not change. The configuration of the end-diastolic left ventriculogram (RAO 30 degrees) changed from a round configuration to the so-called "beak" configuration. 2) Two patients (A-2 group) showed a decreased voltage of SV1 + RV5 (81 mm----26 mm, 73 mm----53 mm), decreased thickness of the apical wall (18 mm----10 mm, 21 mm----15 mm) and the anterior wall (12 mm----9 mm, 17 mm----12 mm). The end-diastolic left ventriculogram changed from a spade-like configuration to a round configuration. In the analysis of diastolic function measured by digitized cineangiograms using a picture-analyzer, diastolic dysfunction was already present at the initial observation. The diastolic and systolic dysfunction progressed during serial observations. These patients showed the clinical pictures of dilated cardiomyopathy at the final observation. 3) Two patients with no remarkable changes of the T wave (B group) showed insignificant changes in configuration of the left ventriculogram and wall thickness. In conclusion, serial changes in configuration of the left ventricle and wall thickness, especially of the anterior and apical walls, are compatible with the serial changes of the ECG in hypertrophic cardiomyopathy. The patients whose negative T waves decreased or disappeared had diastolic dysfunction at the initial observation, and deterioration of both diastolic and systolic dysfunctions during serial observations.

Adult↗
PubMed1987

[Family study of cancer among gastrectomized patients].

The purpose of this study was to examine whether patients with gastric cancer differ from those with benign gastroduodenal diseases in terms of familial disposition. This series consisted of 1,233 patients with gastric cancer and 2,200 patients with benign gastroduodenal diseases, who had had a gastrectomy between 1972 and 1979 in one hospital. The family information on cancer deaths of first and second relatives of the patients was obtained at the time of operation. The age-adjusted relative risk of positive family history of cancer was higher among the patients with gastric cancer than that among those with benign gastroduodenal diseases. The patients with diffuse type of cancer had a higher risk of positive family history than those with intestinal type of cancer. The non-cancer patients with family history had a slightly higher risk, although not statistical significant, to die from cancer than those without family history. Higher frequency of blood type A was seen in gastric cancer patients with positive family history. These results suggest that certain types of gastric cancer may seem to be associated with genetic factor.

ABO Blood-Group System↗
PubMed1987

[Erythrocyte calcium and pH levels during postoperative tetany following radical operations for thyroid cancer].

To investigate the mechanism of postoperative tetany, erythrocyte calcium and pH were consecutively measured in 15 patients who underwent total removal and subsequent autotransplantation of parathyroid glands at the surgery for thyroid cancer. Of these, 8 patients presented tetany signs, but the other 7 patients had no symptoms. In the non-tetanized group, the concentration of erythrocyte calcium decreased by 33.2% and 46.0% on the 3rd and 5th postoperative day, respectively. On the other hand, it increased by 49.8% and 34.6%, respectively, in the tetanized group, showing a significantly different concentration between two groups. No significant differences were observed, however, in the serum calcium level at any time between two groups. The erythrocyte pH as well as the plasma pH in the tetanized group was significantly higher on the 3rd postoperative day, than that in the non-tetanized group. These results suggest the possibility that the elevated cellular calcium content is more closely linked with postoperative tetany than the serum calcium level, and that the elevated cellular pH as well as plasma pH is another causative factor in evoking tetany.

Adult↗
PubMed1987

[A case of familial breast cancer--identical twin sisters with a heterochronic bilateral breast cancer that developed at the same age].

We have encountered very unique cases which involve identical twin sisters who underwent surgical treatment for a unilateral breast cancer at the same age of 28. Each, after 13 years, developed cancer in the opposite breast. In addition yet another sister, the youngest, had to undergo the same surgical procedure, at the same age that her identical twin sisters had had their first operations. These findings may indicate the existence of factors which decide the age of the malignancy onset, in addition to the existence of a predisposing factor for carcinoma in the genes of breast cancer patients.

Adult↗
PubMed1986

Transposable genetic element found in the 5'-flanking region of the fibroin H-chain gene in a genomic clone from the silkworm Bombyx mori.

A transposable genetic element was found in the 5'-flanking region of the fibroin H-chain gene in one of the genomic clones from the silkworm Bombyx mori. This element, named K-1.4, is about 1 X 4 X 10(3) base-pairs long, contains an open reading frame of only 225 base-pairs and has inverted repeats of 12 base-pairs at both ends. Duplication of three base-pairs seems to have occurred when this element was integrated into the silkworm genome. About 15 copies of K-1.4 are present per haploid genome of various silkworm strains. Genomic loci of some of these elements are different among different strains or even among individual offspring of the same parents. K-1.4 is present also in the genome of Bombyx mandarina. The K-1.4-related sequences are present in some species belonging to the family Saturniidae.

Animals↗
PubMed1986

Clinical studies on diabetic myocardial disease using exercise testing with myocardial scintigraphy and endomyocardial biopsy.

Nine diabetics without significant coronary stenosis participated in an exercise testing protocol with thallium-201 myocardial scintigraphy. Endomyocardial biopsy of right ventricle was also obtained. There were 4 patients with abnormal perfusion (positive group) and 5 patients with normal perfusion (negative group). All cases of the positive group were familial diabetics and there was only one case of dietary treatment, whereas in the negative group, there were only 2 cases of familial diabetics and 3 cases receiving dietary treatment. No statistical differences between the positive and negative groups were observed for the data of exercise performance and hemodynamic parameters in cardiac catheterization at rest. However, the mean ejection fraction in the positive group (62 +/- 13%) was significantly lower than in the negative group (77 +/- 4%). In both groups, the mean diameter of myocardial cells and the mean percent fibrosis of biopsy specimens showed significant increases compared with the control group. The mean percent fibrosis in the positive group (24.1 +/- 8.5%) compared with that in the negative group (16.5 +/- 5.9%) showed a tendency to increase. It is suggested that the abnormal perfusion of thallium-201 in the positive group indicates subclinically a pathological change of microcirculation caused by diabetes mellitus.

Adult↗