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Biomedical subjects

S Miyazaki

Publications and source records attributed to S Miyazaki.

At least 937 records · Page 52Linked to original sources
PubMed1976

Elevated plasma renin activity in aortitis syndrome.

Plasma renin activity (PRA) was measured in 38 cases of aortitis syndrome. The values of resting peripheral vein blood PRA were 32.2 +/- 4.2 (SE) mmug/ml. These values were 3 times higher than those of normal subjects. Hypertension due to renal arterial stenosis was observed in 18 cases. Their resting PRA values were 41.2 +/- 6.0 mmug/ml, while in the remaining 20 patients without renovascular hypertension those values were 24.2 +/- 5.4 mmug/ml. The patients belonging to aortic arch type or extensive type had 2 times higher PRA values than those of abdominal type. The patients with stenosis or obstruction of common carotid arteries had significantly higher PRA values than the patients without these lesions. Hyperresponse of renin secretion to upright posture was also observed in the same patients with carotid artery stenosis. Abnormal renin release in Takayasu's arteritis disappeared after denervation of the carotid sinus nerve. The present study suggests that the unstable state of carotid sinus reflex is the main cause for the hypersecretion of renin.

Adolescent↗
PubMed1976

Postoperative course of blood pressure and plasma renin activity in patients with renovascular hypertension.

Thirty patients with renovascular hypertension were treated surgically, and they were divided into two groups according to the kinds of operations they received; nephrectomized group (group A) and revascularized group (group B). Postoperative blood pressure was followed periodically in each patient of two groups. In all patients with an excellent result (diastolic pressure of 90 mmHg or lower without antihypertensive therapy), blood pressure returned to normal within 30 postoperative days. Normal blood pressures were obtained within 3 weeks in eighty-four per cent of them. The normalization of blood pressure following operation was more rapid in group B than in A. The postoperative plasma renin activity (PRA) was determined serially in 10 patients. PRA became normal in 9 within 3 days and in one within 7 postoperative days. The restoration of PRA preceded the normalization of blood pressure. The normalization of PRA was quicker in group A than in B. It is likely that the renal antihypertensive mechanism, suppressed in the ischemic kidney and set again in motion by revascularization, mainly causes this difference in the postoperative changes in PRA and blood pressure between the two groups. It may be concluded that these findings are suggestive of an important role of impaired renal antihypertensive function in the maintenance of high blood pressure in chronic renovascular hypertension in man.

Adolescent↗
PubMed1975

Renal effects of prostaglandin E1 in hypertensive patients.

The effects of prostaglandin E1 on fluid and sodium excretion, creatinine clearance and renin release were examined in 26 hypertensive patients including 9 cases of essential hypertension, 10 of renovascular hypertension and 7 of primary aldosteronism. When prostaglandin was infused intravenously in a total dose of 120 mug in 60 min, urine volume was increased in 70% of cases, and sodium excretion in 61%, but little changes were observed in creatinine clearance. The most prominent diuresis and natriuresis were obtained in primary aldosteronism (mean increase was 319% in urinary volume, and 222% in sodium output). The average increases in urinary volume were 61% in patients with essential hypertension and 97% in renovascular hypertension. And urinary output of sodium was increased by 63% in the former and 56% in the latter. The remarkable renal effects of prostaglandin E1 in primary aldosteronism were completely abolished after the administration of spironolactone. Significant elevation of plasma renin activity resulted from prostaglandin E1 infusion in essential hypertension, while no constant effect was obtained in renovascular hypertension and primary aldosteronism. The present experiments indicate that prostaglandin E1 has different effects on the kidney according to the types of hypertension and the effects correlate closely with patient's status of extracellular fluid volume or sodium balance.

Adolescent↗