Xeroderma pigmentosum (case report).
Xeroderma pigmentosum is a rare, hereditary and fatal disease of the skin. Ocular involvement is known to occur in 80% of cases. A case with typical cutaneous and ocular lesions is reported.
Child↗
Biomedical subjects
S Mishra
Publications and source records attributed to S Mishra.
Inflammatory pseudotumor of the liver. Report of the fine needle aspiration cytologic findings in a case initially misdiagnosed as malignant.
The fine needle aspiration (FNA) cytologic features are described in a case of inflammatory pseudotumor of the liver (xanthogranuloma), a disease generally regarded as of unknown etiology. The initial FNA findings were those of an acute exudative process, with atypical biliary duct epithelium and hepatocytes. These were interpreted as verifying the radiologic impression of a malignancy. Histologic study of subsequently resected nodules revealed the true nature of the case. As the lesion evolved, granulomatous inflammation supervened, characterized by numerous foamy histiocytes and lesser populations of plasma cells and lymphocytes. Numerous gram-positive cocci were readily demonstrated, suggesting that the lesion was an unusual tissue response to an intrahepatic bacterial infection. The lesion eventually resolved with prolonged antibiotic therapy.
Biopsy, Needle↗
Interferon-enhancement of tyrosine phosphorylation of epidermal growth factor receptors in human breast carcinoma cells.
Interferons have been postulated to inhibit cell growth by modulating the cellular response to growth factors. We now demonstrate that interferon increases tyrosine phosphorylation of EGFR in the human breast carcinoma cell line MDA 468, in the presence of EGF. The kinase activity of EGFR was elevated about two-fold when cells were cultured in the presence of IFN. Antiphosphotyrosine immunoblotting revealed that phosphorylation was increased two-fold on tyrosine residues in EGFR. These results suggest that IFN affects EGF signal transduction, and that such changes may play a role in growth inhibition induced by IFN in MDA 468 cells.
Breast Neoplasms↗