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Biomedical subjects

S Mingrino

Publications and source records attributed to S Mingrino.

At least 37 records · Page 2Linked to original sources
PubMed1981

[The diagnostic value of the CT scan in subarachnoid haemorrhage from intracranial aneurysms (author's transl)].

Fifty cases of subarachnoid haemorrhage from aneurysms are reported. Computer tomography gave direct evidence of aneurysm in 13 cases and indirect signs in 25 cases. In the remaining 12 cases the aneurysm could not be located. Apart from this we were able to demonstrate 16 intraventricular haemorrhages, 16 intracerebral haemorrhages, six cases of oedema of the brain, nine subarachnoid haemorrhages and, finally on 31 occasions enlargement of the ventricles. The role of the CT scan has been investigated in terms of its value in the planning and execution of surgical treatment.

Brain Edema↗
PubMed1981

Cortical-evoked responses before and after percutaneous thermocoagulation of the Gasserian ganglion. Preliminary report.

Percutaneous thermocoagulation of the Gasserian ganglion allows a good preservation of facial touch sensation with a complete and immediate regression of the symptomatology in a majority of cases. Neurophysiological bases are the peculiar resistance to the thermal lesion of the large myelinated fibers compared to the relatively smaller fibers. The study of the cortical-evoked responses before and after surgery suggests that the afferent volley travels in preference along these large myelinated fibers.

Cerebral Cortex↗
PubMed1981

Evaluation of endorphin content in the CSF of patients with trigeminal neuralgia before and after Gasserian ganglion thermocoagulation.

The beta-endorphin content in cerebrospinal fluid (CSF) was evaluated in 10 patients with idiopathic trigeminal neuralgia during medical treatment (with or without carbamazepine) and after selective thermocoagulation of the Gasserian ganglion. These values were compared with those obtained in a control group of seven patients without pain problems. No statistically significant difference was found between patients suffering from trigeminal neuralgia and those without pain. Furthermore, neither pharmacological treatment nor surgery changed CSF endorphin values. It is concluded that there is no pathogenetic relationship between trigeminal neuralgia and endorphins.

Adult↗
PubMed1980

Functional classification of pituitary adenomas.

Results of clinical, endocrinological, and ultrastructural studies of 60 cases of pituitary tumours are presented. A functional classification of such tumours that would: allow a clear correlation between clinical symptoms and the adenoma type, is discussed together with data available from the literature. A case of pituitary adenoma secreting more than two hormones is presented.

Adenoma↗
PubMed1980

Treatment of benign intracranial hypertension.

This study is based on 11 cases with pseudotumour cerebri. In each case a high dose of Escin was administered intravenously, and the drug effect during ICP recording was observed. In seven cases the drug manifested a significant hypotensive effect. In these cases the treatment with Escin (20 mg every 8 hours) was continued for 3 days; the control if ICP after this period showed a normal pressure in all cases. Oral treatment was continued at the same dosage for 20-30 days and the patient was then discharged. All patients presented complete remission of the clinical syndrome and fundus normalization. Follow-up after a year showed no recurrence. In three cases the treatment with Escin was unsuccessful; these patients were given dexamethasone, with normalization of the syndrome. Another case that presented with a severe picture of intracranial hypertension and visual impairment was treated with Escin and dexamethasone without positive results. The patient improved with external CSF drainage, and was treated by a shunt procedure that induced remission of the syndrome.

Adolescent↗
PubMed1980

Cortical evoked responses and transcutaneous electrotherapy.

Percutaneous electrostimulation, acupuncture, and direct stimulation of the central nervous system are supposed to be capable of reducing painful sensation by releasing enkephalins and endorphins. We treated six volunteers with electrotherapy, obtaining in all cases a clear reduction of the pain induced by electric stimulation of the median nerve at the wrist. During the treatment, the administration of naloxone, an antagonist of morphine, in four subjects provoked a short but clear and immediate return of pain. In the other two cases, the drug provoked a further decrease of the painful sensation. During electro-stimulation in all patients, the somatosensory evoked potentials showed a statistically significant decrease. In the four "naloxone-responsive" subjects, the cortical evoked responses returned to basal amplitude after naloxone. In the two patients with a clinically paradoxic response, nonsignificant modification in the cortical evoked potentials was noted.

Adult↗
PubMed1980

Tapia's syndrome caused by a neurofibroma of the hypoglossal and vagus nerves: case report.

Tapia's syndrome is characterized by unilateral paralysis of the tongue and vocal cord, and is caused by a lesion of the 10th and 12th cranial nerves below the nodose ganglion, without involvement of the pharyngeal branches of the 10th nerve. The authors report the case of a 25-year-old man who presented with a 4-year history of progressive glossolaryngeal paralysis. Operation through the right laterocervical region allowed complete removal of a neurofibroma involving the 10th and 12th nerves at their crossing below the nodose ganglion.

Adult↗
PubMed1980

Alterations in ventricular size and intracranial pressure caused by sagittal sinus pathology in man.

Lumbar cerebrospinal fluid (CSF) pressure and ventricular size were determined in six patients with impairment of cerebral venous outflow caused by either sagittal sinus thrombosis or arteriovenous shunting into the sagittal sinus. None of the patients had enlargement of the ventricular system, but all six had elevated CSF pressure (mean, 30 mm Hg). At least two mechanisms sufficient to prevent ventricular enlargement and significant hydrocephalus are suggested by these cases: 1) intracranial pressure elevations that occur as a result of cerebral venous outflow impediment maintain a positive pressure gradient between the intracranial CSF and the sagittal sinus contents, thereby increasing bulk CSF outflow; 2) in adults, increased function of alternative CSF outflow pathways occurs secondary to sagittal sinus thrombosis across the arachnoid villi of other intracranial vascular structures and in the spine. These mechanisms may have general importance in the generation of hydrocephalus caused by other disease states in adults but not in children.

Adult↗
PubMed1980

An electron microscope study of human arachnoid villi.

The fine structure of human arachnoid villi obtained by surgical biopsy during operations for intracranial diseases was investigated by electron microscopy. The observation of the cerebrospinal fluid-blood interface, represented by the endothelial covering of arachnoid villi, provided ultrastructural evidence for both "closed" and "open" systems for CSF reabsorption. Ultrastructural findings such as micropinocytotic vesicles, giant intracellular vacuoles, gaps between endothelial cells and tubul-like endothelium-lined structures, previously identified in animals by other workers, were for the first time demonstrated in human specimens.

Absorption↗
PubMed1979

Subarachnoid haemorrhage of unknown aetiology.

One hundred and forty consecutive subarachnoid haemorrhages (SAH) which presented either an intracranial vascular malformation (102 cases: aneurysm 80 cases, AVH 22 cases) or remained of "unknown aetiology" (38 cases) were studied. SAH caused by other factors (neoplasms, thrombo-embolisms, systemic diseases etc.) were excluded. The 38 cases with bleeding of "unknown aetiology" have been studied by complete cerebral angiography, pneumoencephalogram or CT scan, and have been followed for two years. The most important clinical factors in the three groups have been compared by a statistical method to verify the hypothesis that SAH of "unknown aetiology" is caused by vascular micromalformations which are angiographically not evident either because of their small size or because of their "spontaneous" recovery after bleeding due to thrombosis and disappearance of the malformation. From the data collected it may be concluded that SAH of "unknown aetiology" is a benign lesion, typically occurring in middle age, but with no clear characteristics that enable identification of the anatomical substratum from it originates.

Adult↗