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Biomedical subjects

S Milosević

Publications and source records attributed to S Milosević.

13 recordsLinked to original sources

Drivers' fatigue studies.

This paper summarizes the results of several fatigue studies of bus and truck drivers using different approaches. It presents findings from 24 city bus drivers obtained by the use of biochemical and psychophysiological tests before and after 7 h of driving. It presents an acoustic speech analysis conducted on 34 bus drivers before and after driving. Also, for a small group of city bus drivers, a continual examination of heart rate was carried out by electrocardiorecorder. Questionnaire studies on fatigue are related to the responses of 200 long-distance truck drivers and 107 dump-truck drivers who work in one copper mine. The last approach deals with the analysis of long-distance truck drivers' activities (driving, loading-unloading, resting and sleeping) during trips, based on their individual records. On the basis of these different approaches to bus and truck drivers' studies, clear psychophysiological, speech and subjective changes have been demonstrated and, on a descriptive level, certain symptoms observed during prolonged driving have been interpreted as effects of drivers' fatigue.

Adult↗

[Malignant tumors in patients in our hospital 1985-1989].

An analysis was conducted concerning the data on malignant digestive-tract tumors which were treated in the period from 1985 to 1989 at the Department for Gastroenterology of the Clinical-Hospital Center in Zemun. The research results showed that malignant digestive-tract tumors are not in an increase, they are rare in persons which are younger than 40 years of age (10%) and are two times more frequent in males. The share of malignant tumors of the large intestine in overall morbidity is somewhat more frequent, they occur two times more in males and with 10.6% in persons younger than 40 years. The malignant tumors of the stomach are the only ones which are in a decrease, they are considerably less frequent in younger persons (3.7%), but are also two times more frequent in males. Malignant tumors of the pancreas are somewhat more represented in overall morbidity, they are very rare in young persons (3.7%) and are more frequent in males. The data on malignant tumors of the liver show that in the last few years they are somewhat more represented in overall morbidity, they are rare in persons younger than 40, and are more frequent in males.

Adult↗

[Therapy of inflammatory changes in Bartholin's glands].

INTRODUCTION: Bartholin's glands are bilateral structures whose function begins after puberty, so the diseases of these glands are most common during the reproductive period. Management of the inflammatory changes--abscess and cyst can be invasive and conservative, and quite often the changes become chronic, due to the failure of techniques. The aim of the study was to assess efficacy of various therapeutic approaches in the treatment of the inflammatory changes of Bartholin's glands. MATERIAL AND METHODS: The study was done at the Department of Obstetrics and Gynecology, Clinical Centre in Novi Sad, during the period 1993-1996, at the Dept. of Inflammatory Gynaecological Diseases. The total of 129 patients was treated. The first two years were analyzed retrospectively while during the years 1995 and 1996 a prospective study was done. The analysis of the therapeutic results was done according to the immediate efficacy of the therapeutic approach, incidence of recurrence, length of hospitalization and use of antibiotics. RESULTS: A total of 129 patients was treated, the mean age was 35.4 years. Cysts were treated in 14.7% and abscess in 85.3% of cases. Therapeutic approaches were different during different years. During 1993 and 1994 in majority of cases incision and complete extirpation of the glands were done, and rarely marsupialization, alone or in combination with silver nitrate (AgNO3). In 1995 and 1996 in a majority of cases incision of the gland was performed, together with the AgNO3 application (94.3% in 1995, 64% in 1996). In 1995 total gland extirpation was performed (5.7%) while in 1996 in 9 cases (36%) incision was done. The length of hospitalization was longer in earlier years, the shortest being when incision and AgNO3 application was performed (3.1/2.4 days). The use of antibiotics was significantly lower in the years when incision and AgNO3 were used. DISCUSSION: Our results are in concordance with the results of similar studies except for the fact that in our group the changes were seen more often in the age group 30-39 years. The parity was of no significance. The recurrence of the disease when this method is applied is the same as in other studies--around 3%, whereas the complications were rare. The length of hospitalization and the cost of the antibiotic therapy is of great significance as well, and they can be brought to minimum by employment of this method. CONCLUSION: The therapeutic approach of incision and AgNO3 application in therapy of inflammatory changes of Bartholin's glands is an efficient, safe, simple and cheap method, which can easily be applied in ambulatory conditions.

Abscess↗

Transvaginal ultrasonographically controlled aspiration of ovarian endometriomas.

Evaluation of the results of the fine needle ultrasonographically directed aspiration of ovarian endometriomas in relation to the efficacy of aspiration of the content, invasiveness, recurrences and complications. The investigation included 30 patients--28 with unilateral and 2 with bilateral ovarian endometriosis in whom 36 aspirations have been performed. Total evacuation of the content was achieved during the first effort in 26 patients versus 4 patients in whom a repeated procedure had to be done. All the patients were controlled during the 1 year post-aspiration period, on average. The recurrence rate was 56.66%. Complications have not been recorded. The transvaginal ultrasonographic fine needle aspiration of the ovarian endometriomas is associated with a high incidence of recurrences but it proved to be a simple, safe, cheap and minimally invasive technique which can be repeated for several times if necessary, in selected patients.

Adolescent↗

[Perinatal infection with the human immunodeficiency virus].

INTRODUCTION: HIV infection, eventually resulting in AIDS, represents an important problem of the present days, whereas statistical parameters corresponding with the incidence of its manifestations and lethal outcome deserve great attention and cause anxieity of both general population and medical workers of all profiles. The problem is particularly complicated in the HIV-infected pregnant women. The aim of this paper is to examine epidemiology of HIV and AIDS, influence of HIV infection on the course and outcome of pregnancy, ways of transmission of HIV infection from mother to child, possible effects of progression of HIV infection and medical procedures and approaches in HIV-infected pregnant women. CLINICAL MANIFESTATIONS AND OPINIONS: Some studies from North America and Europe demonstrated an adverse effect of HIV-1 infection on pregnancy outcome, others failed to confirm these findings. Most studies from Africa describe an untoward effect of HIV-1 infection on pregnancy outcome, including fetal wastage, prematurity, low birth weight, stillbirth and neonatal death, but not in terms of embryopathy or congenital abnormalities. The incidence of perinatal transmission varies from 13% and 48%, 13% to 32% for the developed world and 25% to 48% for developing countries. Transmission can take place antepartum, during delivery and postpartum by breastfeeding. Transmission during the first trimester may take place but current data suggest that a substantial proportion of perinatal HIV-1 transmissions take place rather late in pregnancy or during delivery. The apparent absence of viral genome from fetal tissue, presence of a normal immune system at birth, absence of neonatal morbidity and reports of differential viral transmission in twins are arguments in favour of late transmission. One of the greatest concerns for both women and their physicians is the possibility that pregnancy may accelerate the onset of AIDS in mother. Pregnancy itself can be immunosupressive and some investigators have hypothesized that the cumulative immunosupressive effect of HIV-1 infection and pregnancy may accelerate the course of HIV-1 infection in pregnant women. Counselling of HIV-positive women worldwide in regard to their HIV serological status has not proved to influence most women's attitudes towards their subsequent reproductive behaviour. MANAGEMENT AND PREVENTION: HIV-infected women should be offered a possibility of an abortion. Ongoing pregnancies should be carefully monitored and CD4 lymphocyte subsets examined at booking. If the CD4 count is below 200 cells/mm, prophylaxis Pneumocystis carinii and Zidovudine therapy should be initiated. Prevention includes changes of behaviour such as reduction of the number of partners, condom use and early and appropriate treatment of sexually transmitted diseases. Antiviral therapy at birth may prevent this type of HIV-transmission. Also vaginal lavage with virus inactivating products such as chlorhexidine has to be assessed as a possible intervention. Prevention of phase 3 transmission (by breast milk) primarily involves recommendation for seropositive mothers not to breats feed their children. Contraceptives should be strongly advocated as soon as possible after giving birth. CONCLUSION: HIV infection, reproduction and motherhood jeopardize millions of women worldwide. The most appropriate approach in preventing perinatal transmission involves preventing HIV-1 infection in women of childbearing age, including sexual education nd condom promotion at a very young age.

Acquired Immunodeficiency Syndrome↗