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Biomedical subjects

S Miller

Publications and source records attributed to S Miller.

At least 613 records · Page 34Linked to original sources
PubMed1969

Termination and functional organization of the dorsolateral spino-olivocerebellar path.

1. Pathways ascending in the lateral funiculus of the spinal cord and terminating as climbing fibres in the anterior lobe of the cerebellum have been investigated in decerebrate cats with the cord partially transected in the third cervical segment, sparing only part of the left lateral funiculus. The climbing fibre responses evoked in Purkinje cells by electrical stimulation of peripheral nerves were studied by recording from single cells and by recording the mass activity at the cerebellar surface.2. Two pathways have been distinguished. One ascends through the dorsal part of the lateral funiculus and relays in the inferior olive. It is denoted the dorsolateral spino-olivocerebellar path (DLF-SOCP) and forms the subject of this paper. The other path occupies in part a more ventral position in the lateral funiculus and it is not known if it relays in the inferior olive. It is denoted the LF-CF-SCP (lateral funiculus-climbing fibre-spinocerebellar path).3. The DLF-SOCP is activated predominantly by cutaneous afferents from restricted areas in the ipsilateral paws. The relay in the spinal cord is almost certainly monosynaptic, but a long delay in the brain stem suggests that the path is interrupted by several synapses at this level. The pathway terminates in the pars intermedia in sagittal zones with a somatotopical organization (Fig. 12).4. Components of the DLF-SOCP and the dorsal spino-olivocerebellar path converge onto the same olivary neurones which project to the pars intermedia and it is concluded on this evidence that the DLF-SOCP also relays in the inferior olive.5. The DLF-SOCP is compared with the other known spinocerebellar paths terminating as climbing fibres in the anterior lobe. The functional role of these paths and the general significance of the sagittal projection patterns are discussed.

Animals↗
PubMed1969

A spinocerebellar climbing fibre path activated by the flexor reflex afferents from all four limbs.

1. A pathway ascending in the lateral funiculus of the spinal cord and terminating as climbing fibres in the cerebellar anterior lobe has been investigated in decerebrate cats with the cord partially transected in the third cervical segment sparing only part of the left lateral funiculus. The climbing fibre responses evoked in Purkinje cells were studied by recording from single cells and by recording the mass activity at the cerebellar surface.2. The pathway is activated by the flexor reflex afferents from all four limbs. It ascends in an area of the lateral funiculus which partly overlaps that of the dorsolateral spino-olivocerebellar path (Larson, Miller & Oscarsson, 1969) but also extends more ventrally. The pathway conducts relatively fast in the spinal cord and is considerably delayed in the brain stem suggesting several interneurones at that level. It projects to a narrow sagittal zone in lobule V of the pars intermedia (Fig. 4).3. It is not known if the pathway relays in the inferior olive and it has provisionally been denoted the LF-CF-SCP (lateral funiculus-climbing fibre-spinocerebellar path).4. The Purkinje cells were usually activated by the flexor reflex afferents from all four limbs with equal effectiveness. On natural stimulation responses were obtained on deep pressure of the limbs.5. The pathway and its functional significance are discussed.

Animals↗