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Biomedical subjects

S Mikuriya

Publications and source records attributed to S Mikuriya.

At least 37 records · Page 2Linked to original sources
PubMed1985

[A clinical study of radiotherapy with HCFU for advanced and recurrent breast cancers. Radiation and HCFU Study Group for breast cancer].

We have investigated the usefulness of combination therapy with radiation and HCFU for advanced and recurrent breast cancer according to a clinical controlled multicenter trial from 1982 to 1984. One hundred cases were registered and 82 of them were available. Treatment sites were the lymph nodes, skin, bone and lung, and the overall response rate was 58% in CR and 19% in PR, while the duration of remission was 18 weeks in CR. Side effects were found in 10% of the patients. Combination therapy with radiation and HCFU may be useful in multimodal treatment for advanced recurrent breast cancer.

Adenocarcinoma, Scirrhous↗
PubMed1983

[Relationship between radiotherapy and tumor immunity in hosts].

There are several opinions which denied therapeutic effects of preoperative irradiation, however, we have obtained favorable results by preoperative irradiation for the advanced breast and stomach cancers. Because we treated them by less-fractionated irradiation method with a large dose instead of conventional fractionated one. We adopted this kind of radiation method for the purpose of enhancing the antigenicity of the cancer cells (that means to inhibit the suppression of immune reaction in hosts). Cases of advanced breast cancer were irradiated with 30 Gy at once or 10 Gy at three times a week (total 30 Gy) by betatron electron and we treated advanced stomach cancer with twice a week method (5 Gy or 3 Gy each time, total 40 Gy) by 6 MV X-ray. Cellular infiltration into the stroma of malignant tumor is able to be considered as cellular immunity of the tumor. The same reaction could be observed in radiotherapy for cancer by using above method. After preoperative irradiation, we examined the resected specimen histopathologically. Remarkable cellular infiltrations into the tumor nests, such as neutrophils, lymphocytes, macrophages and plasma cells were observed and these cellular infiltrations after the preoperative irradiation were more remarkable than the cases without radiotherapy or with conventional fractionated radiotherapy. The abscopal effects could be seen in several cases. Peripheral lymphocytes, T cells, B cells and blastoid formation rate induced by PHA in vitro were all increased after less-fractionated irradiation. The reaction to 4 kinds of immunological skin tests was also enhanced.

Adult↗
PubMed1981

Clinical evaluation of intraoperative radiotherapy for carcinoma of the urinary bladder.

Intraoperative radiotherapy using one shot high dose electron irradiation was performed for 116 bladder cancer patients as a radical means of treatment for superficial bladder cancer. Additional fractionated external supervoltage irradiation covering the whole bladder was given in most of the cases. The one-, three-, and five-year survival rates were 100%, 100%, and 96.3% for T1 cases and 100%, 87.2%, and 61.6% for T2 cases, respectively. Heterotropic recurrences in the bladder were 5.3% within one year, 9.4% within two years, and 19.3% within five years, respectively. Normal vesical function was well preserved except in five patients who underwent total cystectomy subsequently because of multiple recurrences after radiotherapy and one patient who underwent urinary diversion because of contracted bladder and progressive bilateral hydronephrosis. Intraoperative radiotherapy was established as a reliable and superior method for the treatment of superficial bladder cancer because of the low recurrence rate and good preservation of vesical functions after treatment.

Adult↗