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Biomedical subjects

S Meyer

Publications and source records attributed to S Meyer.

At least 289 records · Page 16Linked to original sources
PubMed1982

Persistent neonatal hypoglycemia due to hyperinsulinism: medical aspects.

Eight neonates with persistent hypoglycemia were seen over a four-year period and a ninth infant with neonatal onset was treated from 9 months of age. Seven infants had high absolute insulin levels (range 12 to 50 microunits/ml) during hypoglycemia whereas two patients had normal levels which were, however, inappropriate for the low blood glucose levels. Six patients with severe intractable hypoglycemia resistant to intensive medical therapy (including high dose diazoxide) had partial or total pancreatectomy, whereas three with relatively controllable hypoglycemia eventually had spontaneous remissions. In one of the medically treated patients, remission occurred at the unusually early age of 4 months. In the six surgically treated patients and in a seventh patient who had a biopsy only, the pancreas showed characteristic pathologic changes compatible with those described as nesidioblastosis or "endocrine-cell dysplasia." Of the six patients followed up for greater than or equal to 24 months, four have normal psychomotor development, despite periods of arrested head growth in early infancy in three of them.

Female↗
PubMed1981

Case report. The pathogenesis of neurovascular complications following penicillin injection.

A 12-year-old patient presented following inadvertent intraarterial injection of benzathine penicillin. Complications manifested as an incomplete cauda equina lesion with ischaemia and necrosis over the buttock in the distribution of the injected artery. Angiography confirmed damage to the superior gluteal artery while histology revealed severe ischaemic damage without evidence of an allergic process. Spasm of the injected vessel with retrograde flow and occlusion by particulate matter can explain the clinical manifestations. The prognosis for these complications is poor and the best approach lies in prevention.

Arteries↗
PubMed1981

[Enzyme-immuno-assay in listeriosis: detection of antibody and antigen (author's transl)].

An enzyme-immuno-assay (EIA) was developed for the determination of antibodies to Listeria monocytogenes O- and H-antigens of serotypes 1 and 4b, which are predominant in the Federal Republic of Germany. The results correlated well with the tube agglutination but the titers in EIA were considerably higher. Thus one advantage of EIA was its sensitivity. In addition, the EIA offers the possibility to detect antibodies belonging to different immunoglobulin classes. The EIA is easy to perform and required smaller amounts of reagents than the tube agglutination. Since optical densitys is determined in the EIA, the data obtained in this system are less variable than the tube agglutination which is read by eye. The method proved also to be useful for the detection of Listeria-Antigen. Approximately 0.3 microgram/ml of H-antigen could still be detected in the EIA. Since the serological diagnosis of Listeria-infections is hampered by the cross-reactions to various other bacterial antigens the detection of Listeria-antigen by a sensitive immunological procedure could be of considerable value. This is especially the case when culture procedures are not promising, e.g. during or after antimicrobial chemotherapy.

Agglutination Tests↗
PubMed1981

Prosthetic replacement in hip fractures: a comparison between the Moore and Christiansen endoprostheses.

Two endoprostheses, the Moore and the Christiansen, for the treatment of fresh intracapsular fractures of the neck of the femur in the aged were compared at intervals of an average follow-up of over two years. There was better hip function, less pain, fewer instances of acetabular intrusion, and a lower incidence of total failure of the prosthesis in the Christiansen group. Using Harris' rating system, the Moore prosthesis group averaged a low score of 55 points, while the Christiansen group averaged 77 points. The latter indicates a fair to good result. The Christiansen prosthesis was most effective in the treatment of intracapsular fracture of the neck of the femur in the aged.

Age Factors↗
PubMed1980

Neonatal hyperinsulinism--surgical and pathologic considerations.

Hyperinsulinism in infancy is most often associated with a diffuse pancreatic lesion designated islet-cell dysmaturation syndrome. This disease is commonly associated with persistent hypoglycemia which usually results from inappropriate secretion of insulin. Urgent medical therapy consisting of hypertonic glucose infusion, frequent feeding, and diazoxide is mandatory in order to prevent central nervous system damage. Where medical means of therapy are not effective, an early 85% subtotal pancreatectomy with preservation of the spleen, is indicated. Nine infants who suffered from hyperinsulinism are reported. In two, medical measures were sufficient to control the disease. One of these patients in whom treatment was started late, remained slightly mentally retarded. Seven patients underwent 85% pancreatectomy. In one of these, an additional 7.5% of the pancreas had to be removed and in a second patient total pancreatectomy was performed in order to control the disease. One patient died on the eighth postoperative day after acute gastric perforation. There was no evidence of residual brain damage in the patients who underwent subtotal pancreatectomy.

Diazoxide↗
PubMed1980

Erythrocyte glyoxalase I and esterase D polymorphisms in four French populations.

The genetic polymorphism of two new erythrocyte markers GLO I (EC 4.4.1.5) and esterase D (EC 3.1.1.1) has been investigated in four French populations: Basques and Toulouse groups (southwest area), Lille and Strasbourg (northern and eastern part of the territory). The distribution of GLO I and EsD alleles within these communities has shown some significant differences. Basques samples are characterized by the highest frequency of EsD1 gene (0.911) and the lower rate of GLO1 (0.364). The observed data are compared with other results previously reported in France and in Western European populations.

Electrophoresis, Starch Gel↗
PubMed1980

A critical efficacy test of cambendazole in equids: the use of the geometric means to assess efficacy.

The anthelmintic efficacy of a 44.5% paste formulation of cambendazole was evaluated in a critical trial performed on 5 horses and a donkey. A dosage of 20 mg/kg showed reduction of mean parasite burdens as follows: Strongylinae greater than 99%; Cyathostominae 94%; immature and adult Oxyuris equi 89 and greater than 99%; Probstmayria vivipara greater than 99% and Habronema muscae 97%. Parascaris equorum and Anoplocephala perfoliata were present in small numbers in individual animals only, and while all were removed by treatment, the small numbers did not justify calculation of a percentage efficacy for these 2 parasites.

Animals↗
PubMed1980

[The changes in acid base balance of the fetus at term in the second stage of labour typed according to the CTG patterns (author's transl)].

This work studies the changes in the acid base balance from the beginning to the end of expulsive stage of 73 labours (52 primiparas and 21 multiparas). These are typed according to the CTG patterns proposed by Melchior. All the pregnancies were normal and at or near term. The variation in pH measured is not the same in the primiparas as in the multiparas. For the multiparas the short stage of expulsion results in little change in the acid base balance, and with little correlation to the CTG type. Conversely for the primiparas the lowering of the pH measured corresponds well to the CTG type. For the type 0 it is 0.04 units of pH for the entire expulsive stage. This corresponds to a fall of -0.004 units of pH for each contraction. For the type 2 the fall is -0.12 units of pH or -0.02 per contraction. For the type 1 (the most frequent pattern seen, 71%) the fall is 0.1 units of pH, or -0.01 per contraction. For this last type of CTG pattern characterized by decelerations synchronous with the contractions, and considered for a long time as innocuous, these figures should alert the obstetrician to not permit the expulsive stage of labour to become unduly long. Finally the use of epidural anesthesia did not modify the fall of pH in this last group.

Acid-Base Equilibrium↗
PubMed1979

[Place of routine amnioscopy in the screening of fetal distress (author's transl)].

In order to assess the benefits of routine amnioscopy in the screening of fetal distress, the CTG score, the pH of umbilical artery and the Apgar score were determined and compared in two groups of patients: one group had meconium stained amniotic fluid (MSAF), the other (control) had clear amniotic fluid. Although the prepathological and pathological CTG scores were more frequent in the MSAF group, the values of the umbilical artery pH had the same distribution in the two groups. The percentage of acidotic fetuses in the MSAF group is very low (2.9 p. 100) and practically the same as in the control group (2.5 p. 100). The Apgar score distribution at one and five minutes is also the same in the two groups. The distribution of CTG scores in acidotic fetuses is the same in the two groups, but the pre-acidotic fetuses born with meconial fluid have more often a pre-pathological or pathological CTG score. Fetuses with normal or suspect CTG-score and nevertheless acidotic or pre-acidotic pH values at birth are equally present whether the liquid is stained or not. Amnioscopy is therefore of no help even in this situation. In conclusion, the discovery of a MSAF is the manifestation of fetal hypoxia in only 2.9 p. 100 of cases: the detection of this condition is better achieved by CTG recordings than by routine amnioscopy.

Amniotic Fluid↗