Search PubMed⌕ Search

Biomedical subjects

S Meller

Publications and source records attributed to S Meller.

47 records · Page 3Linked to original sources
PubMed1990

Impact of childhood cancer on return to normal schooling.

Most of the research into the psychosocial impact of treatment for cancer in children has concentrated on effects on the family rather than on the children's return to school. Thus parents and teachers were questioned about the problems experienced by 117 children who returned to school after spending time in hospital. The children comprised 51 with cancer and two groups of control children (34 with chronic diseases such as renal disease and cardiac conditions and 32 with orthopaedic conditions such as thoracic scoliosis, club foot, and injuries resulting from trauma). Children in all three groups experienced problems on returning to school, the greatest number and variety occurring in the children treated for cancer and the fewest in the children with orthopaedic conditions. The variety of physical problems was greatest and the variety of academic problems was least, with psychological and behavioural problems intermediate. Several problems seemed to be related to drug treatment. Several children missed a considerable amount of full time education. Many teachers were unsure of the academic expectations and physical capabilities of children returning to school. To facilitate a smooth return to school for a child with cancer improved liaison is needed between the hospital, school, and home during the child's absence and teachers need to be better informed.

Adolescent↗
PubMed1989

Bilateral ureteral obstruction: an unusual complication of pancreatitis.

A case of bilateral ureteral obstruction associated with alcoholic pancreatitis in a 40-yr-old male patient is reported. Although pancreatitis complicated by pseudocyst formation has been known to involve intra- and extraabdominal organs, bilateral ureteral obstruction has not been reported. We postulated that in the case reported herein, periureteral fat necrosis involving both ureters was the primary etiological mechanism.

Adult↗
PubMed1988

Bilateral ureteral necrosis and obliteration secondary to pancreatic pseudocyst.

We report an unusual case of bilateral distal ureteral necrosis and obliteration associated with a pancreatic pseudocyst. After cyst drainage bilateral ureteral obstruction developed, requiring surgical correction. While it is known that a pancreatic pseudocyst can cause extensive damage to contiguous organs, to our knowledge this case represents the first report of ureteral necrosis and obliteration resulting from pancreatic enzyme damage to the ureters.

Fat Necrosis↗
PubMed1987

Three-dimensional display of data obtained by single photon emission computed tomography.

Three-dimensional display of radioactive distributions has been achieved using data generated by single photon emission computed tomography (SPECT). Computer techniques for constructing images are presented and the special problems associated with manipulating SPECT data are reviewed. The potential role of three-dimensional imaging in nuclear medicine is discussed and SPECT studies from several illustrative cases are presented.

Adult↗
PubMed1978

A correlative microscopical analysis of differentiating ovarian follicles of mammals.

The mammalian ovary has been studied by optical microscopy and by scanning and transmission electron microscopy with the purpose of presenting an integrated view of the differentiating mammalian follicle. During follicular development, changes in the granulosa cells are particularly noteworthy and include dramatic modifications in cell shape coincident with antrum formation. The cytoplasmic processes of those granulosa cells immediately surrounding the oocyte, as well as the more peripheral granulosa cells comprising a second and third layer, traverse the zona pellucida, infrequently interdigitate with the microvilli of the egg, and make both desmosomal and gap junction contacts with the oocyte. The zona pellucida is thus distinguished by numerous fenestrations of varying diameters. The membrana limitans (basal lamina) is a bipartite structure composed of (a) a homogenous stratum upon which the peripheral layer of granulosa cells rests, and (b) an outer region of collagen-like fibers. The specific advantages and limitations of the different methodologies utilized to study folliculo-genesis are discussed.

Animals↗
PubMedDate not supplied

A comparison of the well-being of family caregivers of elderly patients hospitalized with physical impairments versus the caregivers of patients hospitalized with dementia.

OBJECTIVES: This study investigated the differences between the level of well-being of caregivers of older patients hospitalized with dementia and the well-being of caregivers of older patients hospitalized with physical impairments. It also explored the relationships between social roles, religious faith, and well-being. SETTING: Two groups were constructed to compare caregivers' well-being levels: caregivers of patients with dementia and caregivers of patients with physical impairments. The groups were caregivers of patients of two geriatric hospitals in central Israel. Patients were categorized by their medical files according to their medical diagnosis. PARTICIPANTS: A total of 107 caregivers participated in this research. Of that number, 46% were caregivers of patients with physical impairments while the other 54% were caregivers of patients with dementia. The patients with physical impairments suffered from stroke, hip fractures, Parkinson's disease, diabetes, and heart and lung diseases. The patients with dementia suffered from Alzheimer's disease or related dementia. Of the total number of patients, 67% were males and 33% were females. INTERVENTION: The caregivers were asked to fill out a questionnaire that included 90 questions. Some of the questionnaires were given to the caregivers to be filled out at home. MEASUREMENTS: The questionnaire integrated three subcategories: well-being, identity accumulation, and religious faith. RESULTS: Differences were found only in the dimensions of social activity. Caregivers of the patients with physical impairments were found to attend synagogues and clubs more than caregivers of the patients with dementia did. The number of the caregivers' social roles were found to have been significantly related to caregivers' mental health. A negative correlation was found between the intensity of religious faith and the level of the caregivers' spouses' self-rated physical and mental health: those of stronger faith rated their physical health lower and were reported to have more symptoms of stress. CONCLUSION: There are no significant differences between the level of well-being of caregivers of patients with dementia and caregivers of patients with physical impairments. Both groups of caregivers are at great risk of compromised physical and mental health, of decreased social activity, and of financial distresses. Various social roles and religious faith may enhance the caregiver's well-being. However, the spouse's religious faith has negative effects on their own well-being. These results call for welfare services and religious organizations to form support groups for family caregivers. They also make clear that all caregivers should benefit from the same social support if their older relatives are hospitalized.

Journal Article↗
PubMedDate not supplied

[131I]metaiodobenzylguanidine and high-dose chemotherapy with bone marrow rescue in advanced neuroblastoma.

High-dose chemotherapy (HDT) and autologous bone marrow rescue (ABMR) is routinely used as consolidation treatment in advanced neuroblastoma. This study is presently examining the efficacy and toxicity of combined [131I]metaiodobenzylguanidine (131I-MIBG) therapy with HDT and ABMR. Five children (4 male, 1 female), median age of 8 years (range 4-11 years) were treated, 3 at relapse and 2 after initial chemotherapy. A single infusion of 131I-MIBG (median activity 11.1 GBq, range 7.4-11.2 GBq) was followed by HDT and ABMR 14-32 days later. High-dose chemotherapy consisted of carboplatin and melphalan in 4 patients, and vincristine, etoposide, carboplatin and melphalan in 1. One patient developed a septicaemia and died, and another failed to engraft; both had extensive bone marrow infiltration at the time of 131I-MIBG therapy. The combined therapy was well tolerated by the three other patients. Two children have relapsed and died (including one who failed to engraft), and 2 are alive 17 and 41 months after ABMR. In the absence of extensive bone marrow metastases, combined therapy offers potential as a means of consolidating treatment in advanced neuroblastoma.

3-Iodobenzylguanidine↗