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Biomedical subjects

S Meijer

Publications and source records attributed to S Meijer.

At least 253 records · Page 14Linked to original sources
PubMed1984

Long term survival following orthotopic liver transplantation in pigs; with special reference to gastric ulcer complications.

A series of 56 orthotopic liver transplantations performed on pigs surviving more than three days is presented. No immunosuppressive agents were given. During life serial liver biopsies and liver function tests were performed. A 30% mortality rate (17 animals) due to gastric ulcer complications was observed. Rejection, as the sole cause of death, was seen in 12 animals; in nine of these a fulminant rejection caused death within 6 to 10 days after transplantation. Five animals died between seven and 60 days because of small bowel obstruction. The occurrence of gastric ulceration complicated by haemorrhage or perforation is not related to morphological and biochemical parameters while biliary drainage patency does not prevent gastric ulceration haemorrhage. Gastric ulceration can occur at any time postoperatively and seems to be unrelated to the liver transplantation itself.

Animals↗
PubMed1984

The treatment of complete rectal prolapse by transabdominal posterior rectopexy.

Fourteen patients with complete rectal prolapse underwent transabdominal posterior rectopexy using a double peritoneal sling fixation technique. Symptoms, sphincter function assessment and a description of the operative technique are reported. Except for one small mucosal prolapse there were no recurrences. The results of our technique are encouraging.

Aged↗
PubMed1983

Some effects of combination chemotherapy with cis-platinum on renal function in patients with nonseminomatous testicular carcinoma.

Renal function in 24 patients with disseminated nonseminomatous testicular carcinoma treated with combination chemotherapy including cis-platinum was examined prospectively. Renal function was monitored by several determinations of glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and serum creatinine, and beta-2-microglobulin. A reduction in GFR and ERPF was found at the end of the induction chemotherapy and at six weeks thereafter. Median GFR and ERPF decreased both 23% (P less than 0.01). Serum creatinine and beta-2-microglobulin concentrations however did not rise. It is suggested that under the influence of chemotherapy with platinum the production of creatinine and beta-2-microglobulin is decreased rendering their serum levels unsuitable as parameters of renal function.

Adult↗
PubMed1983

Palliative resection in gastric cancer.

Fifty-one of 256 patients underwent a palliative procedure for advanced carcinoma of the stomach (TNM stage IV). The resection was classified as palliative if metastatic disease was left behind in the lymph nodes, if involvement of organs elsewhere in the abdominal cavity was present, or if microscopy revealed tumor tissue in the resection lines. Twenty-six patients underwent a resection for palliation. There were 14 total and 12 partial gastrectomies. There were 2 deaths after total gastrectomy because of anastomotic leakage. The mean survival time after operation was 9.5 months. In 13 patients (50%) palliation was good with preoperative symptomatic relief without initiating new symptoms, acceptable body weight, and solid food intake. In 7 patients (27%) palliation was moderate, and in 4 (15%) poor. The results after gastroenterostomy in 25 patients were poor. The study shows that palliative total and partial gastrectomy can produce palliation in advanced gastric cancer.

Adenocarcinoma↗
PubMed1983

Influence of combination chemotherapy with cis-diamminedichloroplatinum on renal function: long-term effects.

Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were determined in 8 patients with disseminated testicular carcinoma before, during and 1 year after termination of a combination chemotherapy with cis-diamminedichloroplatinum (CDDP). The decrease in median GFR in comparison with the pretreatment value was 15.5% at the start of the maintenance therapy, 23% at the end of the maintenance therapy and 15.5% 1 year after termination of therapy. The comparable reduction in ERPF at those instants was 15.5, 19 and 23.5%, respectively. At all intervals the changes in GFR were significantly reduced in comparison with pretreatment values. No significant change in both GFR and ERPF was found either during or after discontinuation of maintenance treatment. The fall in ERPF was significant during the total period of treatment as well as during the total time of observation. Thus, no cumulative nephrotoxicity during therapy, nor improvement in renal function thereafter was found. Serum levels of creatinine and beta-2-microglobulin did not express the changes in renal function.

Adult↗
PubMed1982

Malignant intrathoracic oncocytoma.

A case of malignant intrathoracic oncocytoma occurring in a 56-year-old man is reported. Preoperative films of the chest showed a large superior mediastinal tumor. Radical excision through a right-sided thoracotomy was impossible because of the extensive growth. Light and electron microscopic findings revealed a malignant oncocytoma with metastases in lymphoid tissue and tumor emboli in lymph vessels. Postoperative treatment with cyclophosphamide was recommended for one year. After two years there was no radiologic or scintigraphic evidence of metastases. Review of the literature on malignant oncocytoma suggests a relatively benign course after surgical excision. The role of radiotherapy and chemotherapy cannot yet be established.

Adenoma↗
PubMed1982

Nephrotoxicity of cis-diamminedichloride platinum (CDDP) during remission-induction and maintenance chemotherapy of testicular carcinoma.

We studied renal function in nine patients with disseminated testicular carcinoma before and after remission-induction and maintenance therapy with a drug combination containing cis-platinum. The median glomerular filtration rate (GFR) decreased during remission-induction therapy from 146 to 118 ml/min. No effect of cumulative toxicity on the median GFR was found during maintenance therapy, nor did the median GFR improve. The median effective renal plasma flow (ERPF) decreased during the total period from 705 to 514 ml/min. No significant changes in median filtration fraction (FF) and serum creatinine were observed. It is suggested that intrarenal hemodynamic effects are important in the nephrotoxicity of cis-diamminedichloride platinum (CDDP).

Adult↗
PubMed1982

Cloacogenic tumors of the anorectal junction.

The cloacogenic zone of the anal canal is a vestigial remnant of the cloacal membrane. This region corresponds to the columnae anales and anal glands. The epithelial lining of the anal glands and of the cloacogenic zone is of the transitional variety. The anal glands are well known to the surgeon because of their role in the pathogenesis of perianal abscesses and fistula in ano. Tumors arising from the cloacogenic zone of the anal canal are rare. In most instants these carcinomas have characteristic clinicopathological features. These lesions are named transitional cloacogenic carcinoma. The therapy of choice is an abdominal-perineal rectum amputation with wide excision of the perineal soft tissue. Inguinal node dissection is indicated if the nodes appear clinically involved. No conclusions have been reached to determine the radiosensitivity of cloacogenic carcinomas. Five cases of cloacogenic carcinoma are reported and the clinicopathological and therapeutic aspects discussed.

Aged↗
PubMed1981

The use of paediatric cadaver kidneys for transplantation in adult recipients.

In view of the shortage of cadaveric donors a retrospective study has been performed to determine the results of transplantation of paediatric cadaver donor kidneys into adult recipients. Graft- and patient survival and renal function in the 31 cases analysed in this study showed no adverse effect of the use of paediatric donor kidneys. No vascular complications were encountered. Ureteric leakage occurred in only one case and it was treated successfully. It is concluded that paediatric age is no criterion for donor exclusion and that paediatric donors are to be regarded as a valuable source of cadaveric kidneys for transplantation.

Adult↗
PubMed1981

Effect of selective proximal and truncal vagotomy on canine gallbladder bile composition.

In 6 dogs the influence of consecutively a selective proximal vagotomy (SPV) and a truncal vagotomy (TV) on gallbladder bile composition was studied. Following SPV no significant changes in biliary lipids were observed. On the other hand, after TV an increase of deoxycholic acid (D) and a concomitant decrease of cholic acid (C) occurred, resulting in a marked increase of the D/C ratio. Although a positive correlation was found between the D/C ratio and the lithogenic index of bile, the change in bile acid composition after TV was accompanied with only a slight, statistically not significant increase of the lithogenic index. It is concluded that in the dog neither SPV nor TV is a definitely lithogenic procedure.

Animals↗
PubMed1981

[The use of juvenile kidneys for transplantation in adults].

In view of the shortage of cadaveric donors a retrospective study has been performed to determine the results of transplantation of paediatric cadaver donor kidneys into adult recipients. Graft- and patient survival and renal function in the 31 cases, analysed in this study, showed no adverse effect of the use of pediatric donor kidneys. No vascular complications were encountered. In only one case ureteric leakage occurred and was treated successfully. It is concluded that paediatric age is no criterion for donor exclusion and that paediatric donors are to be regarded as a valuable source of cadaveric kidneys for transplantation. Also the possibility to perform nephrectomies in anencephalic newborn infants is to be considered.

Adolescent↗
PubMed1981

Transplantation of cadaveric paediatric donor kidneys into adult recipients.

To assess the justification for the use of cadaveric paediatric donor (CPD) kidneys in adult recipients, the results of transplantation of 50 CPD kidneys into adult recipients (CPD group) were compared to the outcome of 250 transplantations of adult cadaveric donor kidneys into adult recipients (ACD group). No differences in graft and patient survival were observed between both groups. The functional capacity of the kidneys and the incidence of surgical and urological complications was not different in both groups. Hypertension was observed more frequently in recipients of CPD kidneys compared to recipients of ACD kidneys (p less than 0.025). The occurrence of hypertension was related to the surgical technique used for the arterial anastomosis. When no arterial patches were available hypertension occurred more frequently in the CPD group (9/9 cases) compared to the ACD group (31/70 cases) (p less than 0.01). In recipients of CPD kidneys the incidence of hypertension was lower then arterial patches were used (11/19 cases) compared to recipients of CPD kidneys where no patches were used (9/9) (p less than 0.05). The results indicate that the use of CPD kidneys in adult recipients is justified. However, to diminish the occurrence of hypertension, donor nephrectomy of CPD kidneys should take place according to the so-called en bloc technique, so that arterial patches can be obtained.

Adolescent↗