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Biomedical subjects

S Mehta

Publications and source records attributed to S Mehta.

At least 397 records · Page 22Linked to original sources
PubMed1984

Lymphokines and monokines as regulators of human lymphoproliferation.

The development of a competent immunoregulatory response in the face of an antigenic challenge is modulated by soluble proteins of relatively low molecular mass. Lymphokines and monokines, secreted by cells of T lineage and cells of the monocyte/microphage series, respectively, function in a bimodal amplification network that results in the proliferation and differentiation of the immunoregulatory cells. Interleukin 1 is typically assayed by its effect on thymocytes or by its ability to promote the T cell-dependent release of interleukin 2. Interleukin 2 is routinely measured by its ability to support the long-term growth of cultured T cells, whereas B cell growth factor is measured by its ability to support the long-term growth of cultured B lymphocytes. The availability of homogeneous purified factors and the subsequent availability of monoclonal antibodies against these reagents should allow for the development of rapid quantitative assays for these analytes in diverse biological fluids. In addition, large quantities of purified reagents will promote studies to determine therapeutic efficacy in several immunodeficiency syndromes.

B-Lymphocytes↗
PubMed1984

Lipid composition of the peripheral nerves in malnutrition: an experimental study in young rhesus monkeys.

An experimental model of protein calorie malnutrition (PCM) was created in young rhesus monkeys. Ulnar and tibial nerves from six monkeys with PCM, six rehabilitated and 12 control monkeys were studied for lipid composition and activity of myelin marker enzyme. Total lipids, myelin marker lipids and activity of myelin marker enzyme, 2', 3'-cyclic nucleotide 3' - phosphohydrolase were decreased, while esterified cholesterol and free fatty acids were increased in PCM as compared to controls. There was partial recovery in myelin marker lipids and complete restoration of other lipids on nutritional rehabilitation.

Animals↗
PubMed1984

In vitro incorporation of (U-C14)-glucose and (1-C14)-sodium acetate in peripheral nerves of malnourished young rhesus monkeys.

The effect of protein calorie malnutrition (PCM) on synthesis of lipids in peripheral nerves was studied by in vitro incorporation of (U-C14)-glucose and (1-C14)-sodium acetate. Ulnar and tibial nerves obtained from five young rhesus monkeys with PCM, five rehabilitated monkeys, and five control monkeys were incubated for 2 h with the radioactive precursors. Uptake of both radioactive precursors in whole peripheral nerves as well as myelin marker lipids was significantly decreased in animals with PCM. However, uptake returned to normal in rehabilitated monkeys.

Acetates↗
PubMed1984

The cross-sectional shape and circumference of the human trachea.

To design a large-volume, low-pressure cuff it is essential to take into consideration cross-sectional shape and circumference of human trachea. Two hundred adult tracheas were dissected and autopsy specimens examined. Cross-sectional tracheal shapes were studied and their circumference measured. There was a definite correlation between sex and the tracheal shapes studied. Forty five per cent of female tracheas were elliptical in shape and 38% were C shaped. The most common cross-sectional tracheal shapes in specimens obtained from male patients were the U shape (33%) and the elliptical (21%). Mean female tracheal circumference was 57.65 mm and mean male tracheal circumference was 68.75 mm. The implications of these findings are discussed and recommendations are made regarding cuff circumference and diameter.

Adult↗
PubMed1984

Safe lateral wall cuff pressure to prevent aspiration.

Although the incidence of cuff induced tracheal damage has been considerably reduced by judicious use of tracheal tubes with large-volume, low-pressure cuffs, aspiration continues to be a major problem. A study was conducted to determine the maximum hydrostatic pressure that can be produced by a column of liquid above the tracheal cuff. The vertical and horizontal distance between the upper central incisor teeth and suprasternal notch was measured in 200 supine adult subjects. The maximum vertical and horizontal distance between the upper central incisor teeth and suprasternal notch was 9 cm and 21 cm respectively. The implication of these findings are discussed and it is suggested that a fixed intracuff pressure in the range of 2.5 to 3kPa should be used to obtain an optimal tracheal seal.

Adolescent↗
PubMed1984

Coeliac disease.

Explore the source record for details and available documents.

Acute Disease↗
PubMed1983

Proliferation of human B lymphocytes mediated by a soluble factor.

Recent studies have established the ability of a proportion of activated human B lymphocytes to undergo G1 phase cell cycle progression and subsequent S phase entry on exposure to factor(s) present in lectin-stimulated mononuclear cell-conditioned media. One factor capable of stimulating activated human B lymphocyte proliferation may be separated from peripheral blood lymphocyte-conditioned media by successive ammonium sulfate precipitation, ion exchange, and gel filtration chromatography. The isolated factor is distinct from the other well-described cytokines, possesses a molecular weight of 12,000-13,000, has a mildly acidic isoelectric point (at pH 6.3-6.6), is protease sensitive, and is relatively heat sensitive. The human B cell mitogenic factor possesses functional and cellular specificity in that its action is restricted to B lymphocytes and its function is proliferative. The production of the B cell mitogenic factor by T lymphocytes is augmented by the presence of a macrophage and further stimulated by syngeneic B cells.

B-Lymphocytes↗