Search PubMed⌕ Search

Biomedical subjects

S McLean

Publications and source records attributed to S McLean.

156 records · Page 9Linked to original sources
PubMedDate not supplied

Opiate and norepinephrine-induced feeding from the paraventricular nucleus of the hypothalamus are dissociable.

Microinjection of d-ala-met-enkephalinamide (DALA) or norepinephrine (NE) into the paraventricular nucleus of the hypothalamus (PVN) elicits feeding. Manipulation of the pituitary-adrenal axis by dexamethasone or adrenalectomy is shown to alter NE- but not DALA-induced feeding. DALA-induced feeding is probably not due to activation of the glucocorticoid sensitive NE feeding system nor due to glucocorticoid-sensitive beta-endorphin release from the anterior pituitary.

Adrenalectomy↗
PubMedDate not supplied

Feeding induced by opiates injected into the paraventricular hypothalamus.

Injection of morphine or d-ala-2-met-5-enkephalinamide (DALA) into the paraventricular nucleus of the hypothalamus (PVN) produced a dose dependent increase in feeding in rats. DALA increased feeding within 45 minutes; morphine within 90 minutes. Naloxone injected into the PVN diminished the effect. DALA increased water intake only when food was available, suggesting the primary effect was on feeding. In summary, an enkephalin analogue induced feeding, and an opiate receptor blocker attenuated it; therefore the PVN may contain opiate receptors that facilitate feeding.

Animals↗
PubMedDate not supplied

A communication analysis of community mobilization on the Warm Springs Indian Reservation.

This article is an analysis of the community mobilization process used at the Warm Springs Indian Reservation as part of a health education campaign. Using the community education model proposed by Freire (1970), it examines the techniques employed to involve community members in radio, print, and public speaking fora, as well as the interpersonal interviews and listening techniques employed by the educators to gain entree to the community. Credibility emerged as a major issue to be addressed in the mobilization process. Other findings include the value of involving community leaders, persistence, and frankness. Caution is urged in implementing the Freirian model without regard to unique community traditions and relationships.

Communication↗
PubMedDate not supplied

The laboratory report: a problem in communication between clinician and microbiologist?

When writing a laboratory report, the microbiologist often makes certain assumptions as to the clinician's understanding of laboratory procedures and reporting practices. The effect of these assumptions on the interpretations of the reports is discussed, with data from a survey of general practitioners. Possible ways of improving communication between the laboratory and the clinician are suggested.

Bacteriology↗
PubMedDate not supplied

N-hydroxyphenacetin, a new urinary metabolite of phenacetin in the rat.

N-Hydroxyphenacetin has been found in the urine of rats dosed with phenacetin, extending previous reports that phenacetin is N-hydroxylated by liver microsomes in vitro. After an oral dose of phenacetin (500 mg/kg) urine was collected for 24 hr, conjugates hydrolyzed with extract of Helix pomatia, and the metabolites extracted with dichloromethane and treated with diazomethane. Methylation of N-hydroxyphenacetin produced a stable derivative, N-methoxyphenacetin, which was separated from most other metabolites by thin layer chromatography. Identification of N-methoxyphenacetin was by combined gas chromatography-mass spectrometry and comparison with the synthetic reference compound. Quantification by gas chromatography with flame-ionization detection showed that 0.023% of the dose phenacetin was recovered from urine as N-hydroxyphenacetin. It is probable that this value considerably underestimates the extent of phenacetin N-hydroxylation in vivo, inasmuch as N-hydroxyphenacetin is known to be rapidly degraded in biological systems.

Animals↗